1.1.1.19: glucuronate reductase

This is an abbreviated version, for detailed information about glucuronate reductase, go to the full flat file.

Reaction

L-gulonate
+
NADP+
=
D-glucuronate
+
NADPH
+
H+

Synonyms

AKR1A1, aldehyde reductase, aldehyde reductase II, ALR1, D-glucuronate dehydrogenase, D-glucuronate reductase, D-glucuronic reductase, hexonate dehydrogenase, L-glucuronate reductase, L-gulonate NAD-3-oxidoreductase, L-hexonate:NADP dehydrogenase, More, NADP-L-gulonate dehydrogenase, TPN l-hexonate dehydrogenase, TPN-L-gulonate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.19 glucuronate reductase

Natural Substrates Products

Natural Substrates Products on EC 1.1.1.19 - glucuronate reductase

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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
D-glucuronate + NADPH
L-gulonate + NADP+
show the reaction diagram
D-glucuronate + NADPH + H+
? + NADP+
show the reaction diagram
-
ALR1
-
-
?
D-glucuronolactone + NADPH
L-gulonolactone + NADP+
show the reaction diagram
gamma-hydroxybutyrate + NADP+
succinic semialdehyde + NADPH
show the reaction diagram
-
preverably in a coupled reaction in vivo with reduction of D-glucuronate
-
-
?
L-gulonate + NADP+
D-glucuronate + NADPH
show the reaction diagram