1.1.1.176: 12alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 12alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

cholate
+
NADP+
=
3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oate
+
NADPH
+
H+

Synonyms

12alpha-HSDH, 12alpha-hydroxy steroid dehydrogenase, dehydrogenase, 12alpha-hydroxy steroid, NAD-dependent 12alpha-hydroxysteroid dehydrogenase, NADP-12alpha-hydroxysteroid dehydrogenase, NADP-dependent 12alpha-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.176 12alpha-hydroxysteroid dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.176 - 12alpha-hydroxysteroid dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
acetone
-
at 25% v/v and above
p-chloromercuribenzoate
-
-
pyridoxal 5'-phosphate
-
protection by NADP+ or NADPH
additional information
-
no substrate inhibition at high concentration of cholic acid
-