1.1.1.176: 12alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 12alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

cholate
+
NADP+
=
3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oate
+
NADPH
+
H+

Synonyms

12alpha-HSDH, 12alpha-hydroxy steroid dehydrogenase, dehydrogenase, 12alpha-hydroxy steroid, NAD-dependent 12alpha-hydroxysteroid dehydrogenase, NADP-12alpha-hydroxysteroid dehydrogenase, NADP-dependent 12alpha-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.176 12alpha-hydroxysteroid dehydrogenase

KM Value

KM Value on EC 1.1.1.176 - 12alpha-hydroxysteroid dehydrogenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0012
12-oxochenodeoxycholic acid
-
-
0.028 - 1.6
3alpha,12alpha-dihydroxy-5beta-cholanoate
0.17 - 0.57
3alpha,12alpha-dihydroxy-5beta-cholanoyl glycine
0.44
3alpha,12alpha-dihydroxy-5beta-cholanoyl taurine
-
-
0.059 - 7
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoate
0.25 - 2.7
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl glycine
0.03
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl methyl ester
-
3alpha,12alpha-dihydroxy-5beta-cholanoate
4
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl taurine
-
-
0.1
7alpha,12alpha-dihydroxy-5beta-cholanoate
-
-
0.072
cholic acid
-
-
0.045
deoxycholic acid
-
-
0.024
NAD+
-
-
0.035
NADP+
-
-
0.0085
NADPH
-
-