1.1.1.176: 12alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 12alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

cholate
+
NADP+
=
3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oate
+
NADPH
+
H+

Synonyms

12alpha-HSDH, 12alpha-hydroxy steroid dehydrogenase, dehydrogenase, 12alpha-hydroxy steroid, NAD-dependent 12alpha-hydroxysteroid dehydrogenase, NADP-12alpha-hydroxysteroid dehydrogenase, NADP-dependent 12alpha-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.176 12alpha-hydroxysteroid dehydrogenase

Molecular Weight

Molecular Weight on EC 1.1.1.176 - 12alpha-hydroxysteroid dehydrogenase

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
26000
-
4 * 26000, no disulfide bonds, SDS-PAGE, electron microscopy; 4 * 26000, SDS-PAGE
58000
-
1 * 58000 + 1* 64000, SDS-PAGE
98000 - 106000
-
native PAGE, analytical ultracentrifugation
102000 - 108000
-
native PAGE, analytical ultracentrifugation, FPLC gel filtration
110000
-
SDS-PAGE, gel filtration
125000
-
gel filtration
225000
-
gel filtration