1.1.1.176: 12alpha-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 12alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

cholate
+
NADP+
=
3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oate
+
NADPH
+
H+

Synonyms

12alpha-HSDH, 12alpha-hydroxy steroid dehydrogenase, dehydrogenase, 12alpha-hydroxy steroid, NAD-dependent 12alpha-hydroxysteroid dehydrogenase, NADP-12alpha-hydroxysteroid dehydrogenase, NADP-dependent 12alpha-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.176 12alpha-hydroxysteroid dehydrogenase

pH Optimum

pH Optimum on EC 1.1.1.176 - 12alpha-hydroxysteroid dehydrogenase

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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5 - 6
-
reduction of dehydrocholic acid
8 - 10.5
-
oxidation of cholic acid
8.5 - 9
-
oxidation of cholic acid
8.5 - 9.5
-
oxidation of cholic acid
8.5 - 10.5
-
oxidation of bile acids
additional information
-
reduction of 12-oxochenodeoxycholic acid optimal below pH 5.0, not measurable due to insolubility of substrate