1.1.1.132: GDP-mannose 6-dehydrogenase

This is an abbreviated version, for detailed information about GDP-mannose 6-dehydrogenase, go to the full flat file.

Reaction

GDP-D-mannose
+ 2 NAD+ +
H2O
=
GDP-D-mannuronate
+ 2 NADH + 2 H+

Synonyms

algD, GDP mannose dehydrogenase, GDP-mannose dehydrogenase, GMD, guanosine diphospho-D-mannose dehydrogenase, guanosine diphosphomannose dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.132 GDP-mannose 6-dehydrogenase

Reference

Reference on EC 1.1.1.132 - GDP-mannose 6-dehydrogenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Preiss, J.
GDP-mannose dehydrogenase from Arthrobacter
Methods Enzymol.
8
285-287
1966
Arthrobacter sp., Arthrobacter sp. NRRL B1973
-
Manually annotated by BRENDA team
Roychoudhury, S.; Mmay, T.B.; Gill, J.F.; Singh, S.K.; Feingold, D.S.; Chakrabarty, A.M.
Purification and characterization of guanosine diphospho-D-mannose dehydrogenase. A key enzyme in the biosynthesis of alginate by Pseudomonas aeruginosa
J. Biol. Chem.
264
9380-9385
1989
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Preiss, J.
Sugar nucleotide reactions in Arthrobacter. II. Biosynthesis of guanosine diphosphomannuronate
J. Biol. Chem.
239
3127-3132
1964
Arthrobacter sp.
Manually annotated by BRENDA team
Pugashetti, B.K.; Vadas, L.; Prihar, H.S.; Feingold, D.S.
GDPmannose dehydrogenase and biosynthesis of alginate-like polysaccharide in a mucoid strain of Pseudomonas aeruginosa
J. Bacteriol.
153
1107-1110
1983
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Deretic, V.; Gill, J.F.; Chakrabarty, A.M.
Gene algD coding for GDPmannose dehydrogenase is transcriptionally activated in mucoid Pseudomonas aeruginosa
J. Bacteriol.
169
351-358
1987
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Horan, N.J.; Jarman, T.R.; Dawes, E.A.
Studies on some enzymes of alginic acid biosynthesis in Azotobacter vinelandii grown in continuous culture
J. Gen. Microbiol.
129
2985-2990
1983
Azotobacter vinelandii
-
Manually annotated by BRENDA team
Couperwhite, I.; McCallum, M.F.
Polysaccharide production and the possible occurrence of GDP-D-mannose dehydrogenase in Azotobacter vinelandii
Antonie van Leeuwenhoek
41
25-32
1975
Azotobacter vinelandii
Manually annotated by BRENDA team
Tavares, I.M.; Leitao, J.H.; Fialho, A.M.; Sa-Correia, I.
Pattern of changes in the activity of enzymes of GDP-D-mannuronic acid synthesis and in the level of transcription of algA, algC and algD genes accompanying the loss and emergence of mucoidy in Pseudomonas aeruginosa
Res. Microbiol.
150
105-116
1999
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Martins, L.O.; Sa-Correia, I.
Alginate biosynthesis in mucoid recombinants of Pseudomonas aeruginosa overproducing GDP-mannose dehydrogenase
Enzyme Microb. Technol.
13
385-389
1991
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Tatnell, P.J.; Russell, N.J.; Gacesa, P.
Overexpression of the GDP-mannose dehydrogenase gene from Pseudomonas aeruginosa
Biochem. Soc. Trans.
24
405S
1996
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Elloumi, N.; Moreau, B.; Aguiar, L.; Jaziri, N.; Sauvage, M.; Hulen, C.; Capmau, M.L.
Inhibitors of GDP-mannose dehydrogenase of Pseudomonas aeruginosa mucoid strains
Eur. J. Med. Chem.
27
149-154
1992
Pseudomonas aeruginosa
-
Manually annotated by BRENDA team
Roychoudhury, S.; Chakrabarty, K.; Ho, Y.K.; Chakrabarty, A.M.
Characterization of guanosine diphospho-D-mannose dehydrogenase from Pseudomonas aeruginosa. Structural analysis by limited proteolyses
J. Biol. Chem.
267
990-996
1992
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Mitsuya, Y.; Kawai, S.; Kobayashi, H.
Influence of macrolides on guanosine diphospho-D-mannose dehydrogenase activity in Pseudomonas biofilm
J. Infect. Chemother.
6
45-50
2000
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Tatnell, P.J.; Russell, N.J.; Gacesa, P.
GDP-mannose dehydrogenase is the key regulatory enzyme in alginate biosynthesis in Pseudomonas aeruginosa: evidence from metabolite studies
Microbiology
140
1745-1754
1994
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Naught, L.E.; Gilbert, S.; Imhoff, R.; Snook, C.; Beamer, L.; Tipton, P.
Allosterism and cooperativity in Pseudomonas aeruginosa GDP-mannose dehydrogenase
Biochemistry
41
9637-9645
2002
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Snook, C.F.; Tipton, P.A.; Beamer, L.J.
Crystal structure of GDP-mannose dehydrogenase: a key enzyme of alginate biosynthesis in P. aeruginosa
Biochemistry
42
4658-4668
2003
Pseudomonas aeruginosa (P11759)
Manually annotated by BRENDA team
Kimmel, J.L.; Tipton, P.A.
Inactivation of GDP-mannose dehydrogenase from Pseudomonas aeruginosa by penicillic acid identifies a critical active site loop
Arch. Biochem. Biophys.
441
132-140
2005
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Li, F.; Yu, J.; Yang, H.; Wan, Z.; Bai, D.
Effects of ambroxol on alginate of mature Pseudomonas aeruginosa biofilms
Curr. Microbiol.
57
1-7
2008
Pseudomonas aeruginosa (P11759), Pseudomonas aeruginosa
Manually annotated by BRENDA team
Shi, X.; Gong, Q.; Cheng, R.
Detection of the key enzyme of alginate biosynthesis in Vibrio sp. QY102
World J. Microbiol. Biotechnol.
24
1613-1615
2008
Vibrio sp. QY102 (A4ZZ81)
Manually annotated by BRENDA team
Tenhaken, R.; Voglas, E.; Cock, J.M.; Neu, V.; Huber, C.G.
Characterization of GDP-mannose dehydrogenase from the brown alga Ectocarpus siliculosus providing the precursor for the alginate polymer
J. Biol. Chem.
286
16707-16715
2011
Ectocarpus siliculosus
Manually annotated by BRENDA team
Manzo, J.; Cocotl-Yanez, M.; Tzontecomani, T.; Martinez, V.M.; Bustillos, R.; Velasquez, C.; Goiz, Y.; Solis, Y.; Lopez, L.; Fuentes, L.E.; Nunez, C.; Segura, D.; Espin, G.; Castaneda, M.
Post-transcriptional regulation of the alginate biosynthetic gene algD by the Gac/Rsm system in Azotobacter vinelandii
J. Mol. Microbiol. Biotechnol.
21
147-159
2011
Azotobacter vinelandii
Manually annotated by BRENDA team