1.1.1.132: GDP-mannose 6-dehydrogenase

This is an abbreviated version, for detailed information about GDP-mannose 6-dehydrogenase, go to the full flat file.

Reaction

GDP-D-mannose
+ 2 NAD+ +
H2O
=
GDP-D-mannuronate
 + 2 NADH + 2 H+

Synonyms

algD, GDP mannose dehydrogenase, GDP-mannose dehydrogenase, GMD, GMD1, GMD2, guanosine diphospho-D-mannose dehydrogenase, guanosine diphosphomannose dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.132 GDP-mannose 6-dehydrogenase

KM Value

KM Value on EC 1.1.1.132 - GDP-mannose 6-dehydrogenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.084
deoxy-GDP-mannose
-
-
0.009 - 0.289
GDP-D-mannose
0.017
GDP-mannose
-
-
0.086 - 0.51
NAD+
additional information
additional information
-
in phosphate buffer, enzyme shows Michaelis-Menten kinetics, in Tris buffer, enzyme shows marked cooperativity with respect to NAD+ binding. Phosphate and GMP are allosteric effectors
-