1.1.1.132: GDP-mannose 6-dehydrogenase

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For detailed information about GDP-mannose 6-dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.132

1.1.1.132

aeruginosa

alginate

cystic

fibrosis

mucoid

mannuronic

midecamycin

sputum

vinelandii

molecular-genetic

azotobacter

erythromycin

macrolide

elastase

chemoenzymatic

gdpmannose

multidrug-resistant

Reaction

+ 2 NAD⁺ +

+ 2 NADH + 2 H+

Synonyms

algD, GDP mannose dehydrogenase, GDP-D-mannose dehydrogenase, GDP-mannose dehydrogenase, GMD, GMD1, GMD2, guanosine diphosphate mannose dehydrogenase, guanosine diphospho-D-mannose dehydrogenase, guanosine diphosphomannose dehydrogenase

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.132 GDP-mannose 6-dehydrogenase

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Results	in table
1535	AA Sequence
1	CAS Registry Number
4	Cloned(Commentary)
18	Cofactor
1	Crystallization (Commentary)
1	Expression
1	General Stability
1	IC50 Value
30	Inhibitors
2	Ki Value [mM]
24	KM Value [mM]
1	Localization
9	Metals/Ions
11	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
32	Organism
7	Pathway
12	PDB ID
8	pH Optimum
1	pH Range
2	pI Value
2	Protein Variants
8	Purification (Commentary)
2	Reaction
3	Reaction Type
25	Reference
1	Renatured (Commentary)
76	Specific Activity [micromol/min/mg]
2	Storage Stability
32	Substrates and Products (Substrate)
9	Subunits
25	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
3	Temperature Stability [°C]

KM Value

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KM Value on EC 1.1.1.132 - GDP-mannose 6-dehydrogenase

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0.084

deoxy-GDP-D-mannose

Arthrobacter sp.

285829, 285831

0.009 - 0.289

GDP-D-mannose

8 entries

0.017

GDP-mannose

Arthrobacter sp.

285829, 285831

0.086 - 0.51

NAD+

10 entries

additional information

Pseudomonas aeruginosa

in phosphate buffer, enzyme shows Michaelis-Menten kinetics, in Tris buffer, enzyme shows marked cooperativity with respect to NAD+ binding. Phosphate and GMP are allosteric effectors

654666