EC Number   |
General Information |
Reference |
|---|
   2.7.1.107 | evolution |
as the smallest kinase known, it shares no sequence homology with conventional kinases and possesses a distinct trimer structure. The phosphorylation reaction of diacylglycerol kinase features the same phosphoryl transfer mechanism as other kinases, despite its unique structural properties. DgkA appears to be an evolutionarily optimized enzyme and its chemical reaction rate approaches the substrate diffusion-controlled rate limit |
739255 |
| 2.7.1.107 | evolution |
comprehensive analysis on the 1-monoacylglycerol kinase (1-MGK) and 2-monoacylglycerol kinase (2-MGK) activities, EC 2.7.1.94, of ten diacylglyceol kinase (DGK) isozymes, EC 2.7.1.107, from different organisms. Type I (alpha, beta, and gamma), type II (delta, eta, and kappa) and type III (epsilon) DGKs have 7.9-19.2% 2-MGK activity compared to their DGK activities, whereas their 1-MGK activities are below 3.0%. Both the 1-MGK and 2-MGK activities of the type IV DGKs (zeta and iota) are below 1% relative to their DGK activities. Type V DGKtheta has approximately 6% 1-MGK activity and below 2% 2-MGK activity compared to its DGK activity. Purified DGKtheta exhibits the same results, indicating that its 1-MGK activity is intrinsic. DGK isozymes are categorized into three types with respect to their 1-MGK and 2-MGK activities: those having (1) 2-MGK activity relatively stronger than their 1-MGK activity (types I-III), (2) only negligible 1-MGK and 2-MGK activities (type IV), and (3) 1-MGK activity stronger than its 2-MGK activity (type V). The 1-MGK activity of DGKtheta and the 2-MGK activity of DGKalpha are stronger than those of the acylglycerol kinase reported as 1-MGK and 2-MGK to date |
737779 |
| 2.7.1.107 | evolution |
comprehensive analysis on the 1-monoacylglycerol kinase (1-MGK) and 2-monoacylglycerol kinase (2-MGK) activities, EC 2.7.1.94, of ten diacylglyceol kinase (DGK) isozymes, EC 2.7.1.107, from different organisms. Type I (alpha, beta, and gamma), type II (delta, eta, and kappa) and type III (epsilon) DGKs have 7.9-19.2% 2-MGK activity compared to their DGK activities, whereas their 1-MGK activities are below 3.0%. Both the 1-MGK and 2-MGK activities of the type IV DGKs (zeta and iota) are below 1% relative to their DGK activities. Type V DGKtheta has approximately 6% 1-MGK activity and below 2% 2-MGK activity compared to its DGK activity. Purified DGKtheta exhibits the same results, indicating that its 1-MGK activity is intrinsic. DGK isozymes are categorized into three types with respect to their 1-MGK and 2-MGK activities: those having (1) 2-MGK activity relatively stronger than their 1-MGK activity (types IIII), (2) only negligible 1-MGK and 2-MGK activities (type IV), and (3) 1-MGK activity stronger than its 2-MGK activity (type V). The 1-MGK activity of DGKtheta and the 2-MGK activity of DGKalpha are stronger than those of the acylglycerol kinase reported as 1-MGK and 2-MGK to date |
737779 |
| 2.7.1.107 | evolution |
DgkA is a unique kinase with a distinctive active site. It has no recognizable nucleotide sequence or structural binding motifs |
739164 |
| 2.7.1.107 | malfunction |
disruption of isoform DGK4 does not impair male gametophytic development but reduces in vivo performance and alters pollen tube Youngs modulus and adhesion properties |
762024 |
| 2.7.1.107 | malfunction |
dysregulation of isoform DGKepsilon perturbs lipid signalling and biosynthesis, which has been linked to epilepsy, Huntington`s disease, and heart disease. Recessive loss-of-function mutations in the isoform DGKepsilon gene cause atypical haemolytic uremic syndrome |
760582 |
| 2.7.1.107 | malfunction |
isoform dgk2-deficient plants are gametophyte lethal, although parental single homozygous plants are viable. The dgk2/dgk4 double heterozygote shows defective pollen tube growth and seed development because of nonviable mutant gametes |
762127 |
| 2.7.1.107 | malfunction |
isoform dgk4-deficient plants are gametophyte lethal, although parental single homozygous plants are viable. The dgk2/dgk4 double heterozygote shows defective pollen tube growth and seed development because of nonviable mutant gametes |
762127 |
| 2.7.1.107 | malfunction |
isoform DGKdelta knockout mice exhibit serotonin transporter inhibitor-sensitive obsessive-compulsive disorder-like behaviors. Moreover, serotonin transporter protein levels are markedly increased in the DGKdelta-deficient brain |
760629 |
| 2.7.1.107 | malfunction |
knockdown of DGKfzeta in cultured neurons decreases spine density |
705262 |
