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Literature summary for 2.7.1.107 extracted from

  • Lu, Q.; Murakami, C.; Hoshino, F.; Murakami, Y.; Sakane, F.
    Diacylglycerol kinase delta destabilizes serotonin transporter protein through the ubiquitin-proteasome system (2020), Biochim. Biophys. Acta, 1865, 158608 .
    View publication on PubMed
Search for more literature for 2.7.1.107

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-7 cells Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 10 mM used in assay conditions Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus E9PUQ8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-palmitoyl-2-oleoyl-sn-glycerol
-
 Mus musculus ADP + 1-palmitoyl-2-oleoyl-sn-glycerol 3-phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 130000, 3x-FLAG-tagged isoform variant DGKdelta2, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
DGKdelta isoform Mus musculus
diacylglycerol kinase delta isoform Mus musculus

General Information

General Information Comment Organism
malfunction isoform DGKdelta knockout mice exhibit serotonin transporter inhibitor-sensitive obsessive-compulsive disorder-like behaviors. Moreover, serotonin transporter protein levels are markedly increased in the DGKdelta-deficient brain Mus musculus
metabolism isoform DGKdelta interacts with melanoma antigen gene-D1 adaptor protein and Praja-1 E3 ubiquitin-protein ligase, and enhances the ubiquitination of serotonin transporter through Praja-1. Isoform DGKdelta interacts with serotonin transporter and induces serotonin transporter degradation in an activity-dependent manner through the Praja-1 ubiquitin ligase-proteasome system Mus musculus