Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
dendrite | - |
Rattus norvegicus | 30425 | - |
dendrite | - |
Mus musculus | 30425 | - |
nucleus | a portion of intracellular DGKzeta protein is localized to the nucleus | Rattus norvegicus | 5634 | - |
nucleus | a portion of intracellular DGKzeta protein is localized to the nucleus | Mus musculus | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q80UP3 | - |
- |
Rattus norvegicus | O08560 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cerebellum | - |
Rattus norvegicus | - |
cerebellum | - |
Mus musculus | - |
hippocampus | - |
Rattus norvegicus | - |
hippocampus | - |
Mus musculus | - |
neuron | dendritic spines on neuronal dendrites | Rattus norvegicus | - |
neuron | dendritic spines on neuronal dendrites | Mus musculus | - |
olfactory bulb | - |
Rattus norvegicus | - |
olfactory bulb | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1,2-diacylglycerol | - |
Rattus norvegicus | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
ATP + 1,2-diacylglycerol | - |
Mus musculus | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DGKzeta | - |
Rattus norvegicus |
DGKzeta | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus | |
ATP | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | DGKzeta mRNA levels are increased in mice on a high-fat diet, but are lower in those that become obese by a high-fat diet | up |
Rattus norvegicus | DGKzeta mRNA levels are increased in rats on a high-fat diet, but are lower in those that become obese by a high-fat diet | up |
General Information | Comment | Organism |
---|---|---|
malfunction | knockdown of DGKfzeta in cultured neurons decreases spine density | Rattus norvegicus |
malfunction | knockdown of DGKfzeta in cultured neurons decreases spine density | Mus musculus |
physiological function | isoform DGKf appears to form a multi-protein complex with functionally related proteins to organize efficient 1,2-diacylglycerol and 1,2-diacyl-sn-glycerol 3-phosphate signaling pathways at excitatory synapses, the DGKzeta isoform at excitatory postsynaptic sites is critically involved in spine maintenance, DGKzeta promotes neurite outgrowth | Rattus norvegicus |
physiological function | isoform DGKf appears to form a multi-protein complex with functionally related proteins to organize efficient 1,2-diacylglycerol and 1,2-diacyl-sn-glycerol 3-phosphate signaling pathways at excitatory synapses, the DGKzeta isoform at excitatory postsynaptic sites is critically involved in spine maintenance, DGKzeta promotes neurite outgrowth | Mus musculus |