EC Number   |
General Information |
Reference |
|---|
    1.1.1.145 | drug target |
16-cyano-17-keto-trilostane is a selective inhibitor of 3beta-hydroxysteroid dehydrogenase type 1. Selective inhibition of beta-HSD1 may prevent spontaneous premature birth. Inhibition of 3beta-HSD1 decreases placental estradiol production that promotes labor. The 3beta-HSD1 inhibitor may be administered with 17alpha-hydroxyprogesterone caproate |
763397 |
| 1.1.1.145 | metabolism |
HSD3B1 is a unique enzyme for progesterone synthesis and is also involved in the estrogen production in human placenta |
763756 |
| 1.1.1.145 | metabolism |
isoform 3betaHSD2 interacts with the mitochondrial translocase, Tim50, to regulate progesterone and androstenedione formation |
740914 |
| 1.1.1.145 | metabolism |
isoform 3bHSD2 interacts with the mitochondrial translocase, Tim50, to regulate progesterone and androstenedione formation |
741250, 741423 |
| 1.1.1.145 | metabolism |
isoform HSD3B1 is involved in aldosterone production in aldosterone-producing adenoma |
740998 |
| 1.1.1.145 | metabolism |
key enzyme involved in the conversion processes from dehydrotomatidine to tomatidine. The enzyme is involved in alpha-tomatine biosynthesis. alpha-Tomatine and dehydrotomatine are major steroidal glycoalkaloids that accumulate in the mature green fruits, leaves and flowers of tomato (Solanum lycopersicum), and function as defensive compounds against bacteria, fungi, insects and animals |
763569 |
| 1.1.1.145 | metabolism |
the content of steroidogenic acute regulatory protein StAR, CYP11A1 and HSD3B1 mRNAs and the secretion of progesterone and androstenedione is modulated by adiponectin in endometrial and myometrial tissue explants during early pregnancy and the oestrous cycle. adiponectin affects basal and insulin-stimulated expression of key steroidogenic genes and production of steroid hormones by the porcine uterus during maternal recognition of pregnancy and implantation |
740898 |
| 1.1.1.145 | metabolism |
the enzyme catalyzes an essential step in the biosynthesis of steroid such as progesterone, estrogens and androgens in steroidogenic tissues. It is probably an important enzyme involved in the biosynthesis of bufadienolides |
763139 |
| 1.1.1.145 | metabolism |
the enzyme is responsible for intermediate steroidogenic reaction for the synthesis of androgens, estrogens, progestins, glucocorticoids, and mineralocorticoids in the adrenal cortex, gonads, placenta, and a variety of peripheral target tissues |
762899 |
| 1.1.1.145 | physiological function |
isoform 3betaHSD2 associates with the inner mitochondrial membrane but does not integrate into the membrane. 3betaHSD2 forms a transient association with the translocases Tim50 and Tom22 and with Tim23. This association occurs primarily through the interaction of Tim50 with the N-terminus of 3betaHSD2 and contributes to enzymatic activity. Tim50 knockdown inhibits catalysis of dehydroepiandrostenedione to androstenedione and pregnenolone to progesterone. Although Tim50 knockdown decreases 3betaHSD2 expression, restoration of expression via proteasome and protease inhibition does not rescue activity |
725447 |
