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Literature summary for 1.1.1.145 extracted from
- Endocrine disruptors of inhibiting testicular 3beta-hydroxysteroid dehydrogenase (2019), Chem. Biol. Interact., 303, 90-97 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| +/-gossypol | potent, competitive | Homo sapiens | |
| 6-hydroxyflavone | very potent, competitive | Homo sapiens |  |
| Biochanin A | very potent | Homo sapiens | |
| bisphenol A | potent, competitive | Homo sapiens | |
| daidzein | very potent | Homo sapiens | |
| etomidate | very potent, competitive | Homo sapiens | |
| formononetin | potent | Homo sapiens | |
| genistein | very potent, competitive | Homo sapiens | |
| ketoconazole | very potent | Homo sapiens | |
| medroxyprogesterone | potent | Homo sapiens | |
| methoxychlor | moderate, noncompetitive | Homo sapiens | |
| myricetin | moderate | Homo sapiens | |
| quercetin | potent | Homo sapiens | |
| resveratrol | potent, competitive | Homo sapiens | |
| tributyltin | potent, competitive | Homo sapiens | |
| Triphenyltin | potent, competitive | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.047 | - |
dehydroepiandrosterone | pH and temperature not specified in the publication | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
| smooth endoplasmic reticulum | membrane-bound | Homo sapiens | 5790 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P26439 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| testis | isoenzyme HSD3B2 | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dehydroepiandrosterone + NAD+ | - |
Homo sapiens | androst-5-en-3,17-dione + NADH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3beta-hydroxysteroid dehydrogenase | - |
Homo sapiens |
| HSD3B2 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme is responsible for intermediate steroidogenic reaction for the synthesis of androgens, estrogens, progestins, glucocorticoids, and mineralocorticoids in the adrenal cortex, gonads, placenta, and a variety of peripheral target tissues | Homo sapiens |
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