Protein Variants | Comment | Organism |
---|---|---|
C83A | mutation produces fully active enzyme with elevated Km values for ligands | Homo sapiens |
C83S | mutation in the active site abolishes the dehydrogenase and isomerase activities of the enzyme | Homo sapiens |
D257I | complete loss of dehydrogenase and isomerase activities | Homo sapiens |
D258I | complete loss of dehydrogenase and isomerase activities | Homo sapiens |
D35A/K36R | double mutations cause conversion of the cofactor dependence from NAD+ to NADP+ | Homo sapiens |
K158Q | complete loss of dehydrogenase activity | Homo sapiens |
S124A | complete loss of dehydrogenase activity | Homo sapiens |
Y154F | complete loss of dehydrogenase activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(+)-gossypol | potent inhibitor, competitive | Homo sapiens | |
(-)-gossypol | weak inhibitor, competitive | Homo sapiens | |
bis (2-butoxyethyl) phthalate | moderate inhibitor, competitive | Homo sapiens | |
di-heptyl phthalate | potent inhibitor, competitive | Homo sapiens | |
di-n-butyl phthalate | potent inhibitor, competitive | Homo sapiens | |
di-n-octyl phthalate | weak inhibitor | Homo sapiens | |
dicyclohexyl phthalate | moderate inhibitor, competitive | Homo sapiens | |
HPTE | potent inhibitor, competitive | Homo sapiens | |
methoxychlor | insecticide, potent inhibitor, competitive | Homo sapiens | |
organotin | can inhibit placental HSD3B1 activity, thus blocking the formation of progesterone and disrupting pregnancy | Homo sapiens | |
tributyltin | moderate inhibitor, competitive | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
smooth endoplasmic reticulum | membrane-bound enzyme | Homo sapiens | 5790 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14060 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mammary gland | - |
Homo sapiens | - |
placenta | intermediate trophoblast and syncytiotrophoblasts | Homo sapiens | - |
prostate gland | - |
Homo sapiens | - |
skin | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dehydroepiandrosterone + NAD+ | - |
Homo sapiens | androstenedione + NADH + H+ | - |
? | |
pregnenolone + NAD+ | - |
Homo sapiens | progesterone + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3beta-hydroxysteroid dehydrogenase/steroid DELTA5,4-isomerase | - |
Homo sapiens |
HSD3B1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | GATA3 negatively regulates the expression of HSD3B1 | down |
Homo sapiens | expression is regulated by GATA2 and TEF-5 transcription factors. GATA2 is the positively regulatory transcription factor | up |
General Information | Comment | Organism |
---|---|---|
metabolism | HSD3B1 is a unique enzyme for progesterone synthesis and is also involved in the estrogen production in human placenta | Homo sapiens |