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Literature summary for 1.1.1.145 extracted from

  • Konosu-Fukaya, S.; Nakamura, Y.; Satoh, F.; Felizola, S.J.; Maekawa, T.; Ono, Y.; Morimoto, R.; Ise, K.; Takeda, K.; Katsu, K.; Fujishima, F.; Kasajima, A.; Watanabe, M.; Arai, Y.; Gomez-Sanchez, E.P.; Gomez-Sanchez, C.E.; Doi, M.; Okamura, H.; Sasano, H.
    3beta-Hydroxysteroid dehydrogenase isoforms in human aldosterone-producing adenoma (2015), Mol. Cell. Endocrinol., 408, 205-212.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.145

Application

Application Comment Organism
medicine in aldosterone-producing adenoma, isoform HSD3B2 mRNA is significantly more abundant than HSD3B1 mRNA, but only HSD3B1 mRNA significantly correlates with CYP11B2 (aldosterone synthase) mRNA and plasma aldosterone concentration of the patients. A significant correlation is also detected between isoform HSD3B1 and CYP11B2. In KCNJ5 mutated aldosterone-producing adenoma, CYP11B2 mRNA and HSD3B1 mRNA are significantly higher than those of wild-type aldosterone-producing adenoma Homo sapiens
medicine in aldosterone-producing adenoma, isoform HSD3B2 mRNA is significantly more abundant than HSD3B1 mRNA, but only HSD3B1 mRNA significantly correlates with CYP11B2 (aldosterone synthase) mRNA and plasma aldosterone concentration of the patients. Isoform HSD3B2 immunoreactivity is detected in the great majority of aldosterone-producing adenoma Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dehydroepiandrosterone + NAD+ Homo sapiens
-
 androst-5-en-3,17-dione + NADH + H+
-
 ?
pregnenolone + NAD+ Homo sapiens
-
 pregn-5-en-3,20-dione + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens P26439
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adenoma cell
-
 Homo sapiens
-
adrenal gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dehydroepiandrosterone + NAD+
-
 Homo sapiens androst-5-en-3,17-dione + NADH + H+
-
 ?
pregnenolone + NAD+
-
 Homo sapiens pregn-5-en-3,20-dione + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
3-beta-hydroxysteroid dehydrogenase
-
 Homo sapiens
HSD3B1
-
 Homo sapiens
HSD3B1 isoform Homo sapiens
HSD3B2
-
 Homo sapiens
HSD3B2 isoform Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism isoform HSD3B1 is involved in aldosterone production in aldosterone-producing adenoma Homo sapiens