EC Number   |
Application |
Reference |
|---|
   2.7.11.20 | agriculture |
manipulation of TaGCN2 gene expression can be used to reduce free asparagine accumulation in wheat grain and the risk of acrylamide formation in wheat products |
723375 |
| 2.7.11.20 | medicine |
eEF-2 kinase plays a regulatory role in the autophagic process in tumor cells, is a downstream member of the mTOR signaling, may promote cancer cell survival under conditions of nutrient deprivation through regulating autophagy. Therefore, eEF-2 kinase may be a part of a survival mechanism in glioblastoma and targeting this kinase may represent a novel approach to cancer treatment |
679022 |
| 2.7.11.20 | medicine |
high expression levels of the enzyme are associated with poor prognosis of hepatocellular carcinoma |
761286 |
| 2.7.11.20 | medicine |
high levels of enzyme expression are associated with invasive carcinoma and metastatic tumors. Inhibiting the enzyme may help prevent cancer cell mobility and metastasis. The enzyme is a potential therapeutic target for preventing tumor metastasis |
761285 |
| 2.7.11.20 | medicine |
plays a regulatory role in the autophagic process in tumor cells and may promote cancer cell survival under conditions of nutrient deprivation, eEF-2 kinase activation may be a part of a survival mechanism in glioblastoma |
677896 |
| 2.7.11.20 | medicine |
suppressing autophagy and augmenting apoptosis via inhibition of eEF-2 kinase can modulate sensitivity of tumor cells to Akt inhibition, and suggest that eEF-2 kinase may be utilized as an effective target for reinforcing the anti-tumor efficacy of Akt inhibitors such as MK-2206 |
721970 |
| 2.7.11.20 | medicine |
the enzyme a possible target for therapeutic intervention in solid tumours |
740015 |
| 2.7.11.20 | medicine |
the enzyme is a valuable target in treating epilepsy, depression and major neurodegenerative diseases |
762016 |
| 2.7.11.20 | more |
eEF2 kinase does not play a role in regulating elongation factor 2 |
680859 |
| 2.7.11.20 | more |
eEF2 kinase is stabilized against decay during hypoxia by phosphorylation |
681906 |
