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Literature summary for 2.7.11.20 extracted from

  • Beretta, S.; Gritti, L.; Verpelli, C.; Sala, C.
    Eukaryotic elongation factor 2 kinase a pharmacological target to regulate protein translation dysfunction in neurological diseases (2020), Neuroscience, 445, 42-49 .
    View publication on PubMed
Search for more literature for 2.7.11.20

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin
-
 Mus musculus

Application

Application Comment Organism
medicine the enzyme is a valuable target in treating epilepsy, depression and major neurodegenerative diseases Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Mus musculus
Zn2+ a Zn2+ ion is required for activity Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [eukaryotic elongation factor 2] Mus musculus the enzyme phosphorylates Thr56 of eukaryotic elongation factor 2 ADP + [eukaryotic elongation factor 2] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus O08796
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus
-
 Mus musculus
-
neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [eukaryotic elongation factor 2] the enzyme phosphorylates Thr56 of eukaryotic elongation factor 2 Mus musculus ADP + [eukaryotic elongation factor 2] phosphate
-
 ?

Synonyms

Synonyms Comment Organism
eEF2 kinase
-
 Mus musculus
eEF2K
-
 Mus musculus
eukaryotic elongation factor 2 kinase
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme deficiency leads to impaired mGluR-long term potentiation, higher miniature inhibitory postsynaptic current frequency and amplitude in hippocampal granule cells, higher tonic inhibition measured in the in granule cells of the dentate gyrus, and impaired AMPAR-endocytosis following mGluR activation. The heterozygous deletion of the enzyme in mice models of Alzheimer's disease rescue cognitive, morphological and electrophysiological alterations associated to Alzheimer's disease Mus musculus