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Literature summary for 2.7.11.20 extracted from

  • Wu, H.; Yang, J.M.; Jin, S.; Zhang, H.; Hait, W.N.
    Elongation factor-2 kinase regulates autophagy in human glioblastoma cells (2006), Cancer Res., 66, 3015-3023.
    View publication on PubMed
Search for more literature for 2.7.11.20

Application

Application Comment Organism
medicine eEF-2 kinase plays a regulatory role in the autophagic process in tumor cells, is a downstream member of the mTOR signaling, may promote cancer cell survival under conditions of nutrient deprivation through regulating autophagy. Therefore, eEF-2 kinase may be a part of a survival mechanism in glioblastoma and targeting this kinase may represent a novel approach to cancer treatment Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
shRNA decreases eEF-2 kinase expression by 90% Homo sapiens
siRNA decreases eEF-2 kinase expression by 90%, inhibition of autophagy in several cell types Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
LN-229 cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
T-98G cell
-
 Homo sapiens
-
U-138MG cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
Ca2+/calmodulin–dependent kinase III
-
 Homo sapiens
eEF-2 kinase
-
 Homo sapiens