Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.20 extracted from

  • Connolly, E.; Braunstein, S.; Formenti, S.; Schneider, R.J.
    Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells (2006), Mol. Cell. Biol., 26, 3955-3965.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.20

Activating Compound

Activating Compound Comment Organism Structure
MG132 addition to normoxic MCF10A cells results in a 5- to 10fold increase in eEF2K levels but has no effect on hypoxic MCF10A or HTB20 cells Homo sapiens
additional information increased eEF2 phosphorylation in hypoxic MCF10A cells is associated with a 5- to 10fold increase in eEF2K protein levels without an increase in eEF2K mRNA levels Homo sapiens

Application

Application Comment Organism
additional information eEF2 kinase is stabilized against decay during hypoxia by phosphorylation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information eEF2K can be directly inhibited by mTOR phosphorylation and indirectly inhibited by mTOR through p70S6k phosphorylation Homo sapiens
shRNA eEF2K protein levels are 8fold reduced Homo sapiens
siRNA eEF2K protein levels are decreased ca. 90% in cells transfected with eEF2K siRNA and unaltered by NS siRNA Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BT-474 cell
-
 Homo sapiens
-
BT-483 cell
-
 Homo sapiens
-
HCC-1395 cell
-
 Homo sapiens
-
MCF-10A cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-175-VII cell
-
 Homo sapiens
-
UACC-893 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
eEF2 kinase
-
 Homo sapiens
eukaryotic elongation factor 2 kinase
-
 Homo sapiens