Literature summary for 2.7.11.20 extracted from

Zhou, Y.; Li, Y.; Xu, S.; Lu, J.; Zhu, Z.; Chen, S.; Tan, Y.; He, P.; Xu, J.; Proud, C.G.; Xie, J.; Shen, K.
Eukaryotic elongation factor 2 kinase promotes angiogenesis in hepatocellular carcinoma via PI3K/Akt and STAT3 (2020), Int. J. Cancer, 146, 1383-1395 .

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Application

Application	Comment	Organism
medicine	high expression levels of the enzyme are associated with poor prognosis of hepatocellular carcinoma	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
A-484954	-	Homo sapiens
NH125	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [elongation factor 2]	Homo sapiens	-	ADP + [elongation factor 2] phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hep-G2 cell	-	Homo sapiens	-
hepatoma cell	-	Homo sapiens	-
HUVEC cell	-	Homo sapiens	-
MHCC97-H cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [elongation factor 2]	-	Homo sapiens	ADP + [elongation factor 2] phosphate	-	?

Subunits

Subunits	Comment	Organism
?	x * 105000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
eEF2K	-	Homo sapiens
eukaryotic elongation factor 2 kinase	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	pharmacological inhibition or knockdown of the enzyme in highly metastatic liver cancer cells inhibits their colony forming and migratory capacities, as well as reducing their invasiveness. Knocking down the enzyme reduces the expression of angiogenesis-related growth factors in liver cancer cells and the expression of growth factor receptors on HUVEC cells, and thus restricts signalling crosstalk that promotes angiogenesis between hepatocellular carcinoma cells and endothelial cells	Homo sapiens
physiological function	the enzyme contributes to angiogenesis and tumor progression in hepatocellular carcinoma via transcription factors SP1/KLF5-mediated endothelial growth factor expression, as well as the subsequent stimulation of PI3K/Akt and STAT3 signalling	Homo sapiens

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Release 2023.1 (January 2023)