Literature summary for 2.7.11.20 extracted from

Xie, J.; Shen, K.; Lenchine, R.V.; Gethings, L.A.; Trim, P.J.; Snel, M.F.; Zhou, Y.; Kenney, J.W.; Kamei, M.; Kochetkova, M.; Wang, X.; Proud, C.G.
Eukaryotic elongation factor 2 kinase upregulates the expression of proteins implicated in cell migration and cancer cell metastasis (2018), Int. J. Cancer, 142, 1865-1877 .

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Application

Application	Comment	Organism
medicine	high levels of enzyme expression are associated with invasive carcinoma and metastatic tumors. Inhibiting the enzyme may help prevent cancer cell mobility and metastasis. The enzyme is a potential therapeutic target for preventing tumor metastasis	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
A-484954	-	Homo sapiens
JAN-384	-	Homo sapiens
NH125	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [eukaryotic elongation factor 2]	Homo sapiens	-	ADP + [eukaryotic elongation factor 2] phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O00418	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-
breast cancer cell	-	Homo sapiens	-
lung cancer cell	-	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [eukaryotic elongation factor 2]	-	Homo sapiens	ADP + [eukaryotic elongation factor 2] phosphate	-	?

Synonyms

Synonyms	Comment	Organism
eEF2 kinase	-	Homo sapiens
eEF2K	-	Homo sapiens
eukaryotic elongation factor 2 kinase	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	knocking down or inhibiting the enzyme in cancer cells impairs migration and invasion of cancer cells	Homo sapiens
physiological function	the enzyme controls the translation of mRNAs encoding proteins involving in cell migration	Homo sapiens

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Release 2023.1 (January 2023)