EC Number   |
Activating Compound |
Reference |
|---|
    1.14.16.4 | more |
in differentiated RN46A cells, the TPH2 promoter is induced 2.5fold by ionomycin, similar to its action on TPH2 RNA. By contrast, ionomycin has no effect onTPH2 promoter activity in GH4C1 cells or TPH2-negative L6 myoblasts, overview |
688507 |
| 1.14.16.4 | more |
phosphorylation at Ser19 by protein kinase A or Ca2+/calmodulin dependent protein kinase II activates TPH2 by about 30%, high-affinity binding of purified PKA-phosphorylated TPH2 bound to the 14-3-3 proteins gamma , epsilon and BMH1 causes further increased enzyme activity, overview |
684993 |
| 1.14.16.4 | more |
phosphorylation of TPH2 at Ser19 within the regulatory domain of the enzyme by calmodulin-dependent protein kinase II activates the enzyme |
688504 |
| 1.14.16.4 | more |
pronase is most effective for activation. Trypsin, chymotrypsin, V8 protease and lysylendoprotease also activate PTMO, but the activity obtained using these proteases is only 5% of that with pronase |
704354 |
| 1.14.16.4 | more |
senescence-accelerated prone mouse 6 show increased serotonin levels, probably due to phosphorylation at Ser58, overview |
684813 |
| 1.14.16.4 | more |
the calcium influx through L-type high voltage-activated calcium channels is essential for the full activation of tryptophan hydroxylase leading to melatonin synthesis in the pineal gland |
688765 |
| 1.14.16.4 | more |
TPH2 is upregulated by dominant-negative RE-1 silencer of transcription, minimum of 4.4fold relative to hypoxanthine-guanine phosphoribosyltransferase, overview |
687604 |
| 1.14.16.4 | N-acetylcysteine |
30 mM, 31.2% activity compared to activation with dithiothreitol |
671723 |
