Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | in differentiated RN46A cells, the TPH2 promoter is induced 2.5fold by ionomycin, similar to its action on TPH2 RNA. By contrast, ionomycin has no effect onTPH2 promoter activity in GH4C1 cells or TPH2-negative L6 myoblasts, overview | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expression in RN46A cells, transcriptional activity of the rat TPH2 promoter, overview | Homo sapiens |
transcriptional activity of the rat TPH2 promoter in GH4C1 cells, RN46A cells, and L6 myoblasts, overview | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activates TPH2 promoter activity | Rattus norvegicus | |
Ca2+ | activates TPH2 promoter activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Rattus norvegicus | - |
5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | Homo sapiens | - |
5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8IWU9 | - |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
brain | - |
Homo sapiens | - |
GH4-C1 cell | pituitary cell line | Rattus norvegicus | - |
HEK-293 cell | - |
Homo sapiens | - |
L6 myoblast | - |
Rattus norvegicus | - |
RN-46A cell | raphe cell line | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | - |
Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPH2 | - |
Rattus norvegicus |
TPH2 | - |
Homo sapiens |
tryptophan hydroxylase-2 | - |
Rattus norvegicus |
tryptophan hydroxylase-2 | - |
Homo sapiens |