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Literature summary for 1.14.16.4 extracted from

  • Lenicov, F.R.; Lemonde, S.; Czesak, M.; Mosher, T.M.; Albert, P.R.
    Cell-type specific induction of tryptophan hydroxylase-2 transcription by calcium mobilization (2007), J. Neurochem., 103, 2047-2057.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information in differentiated RN46A cells, the TPH2 promoter is induced 2.5fold by ionomycin, similar to its action on TPH2 RNA. By contrast, ionomycin has no effect onTPH2 promoter activity in GH4C1 cells or TPH2-negative L6 myoblasts, overview Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expression in RN46A cells, transcriptional activity of the rat TPH2 promoter, overview Homo sapiens
transcriptional activity of the rat TPH2 promoter in GH4C1 cells, RN46A cells, and L6 myoblasts, overview Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates TPH2 promoter activity Rattus norvegicus
Ca2+ activates TPH2 promoter activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Rattus norvegicus
-
5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
L-tryptophan + tetrahydrobiopterin + O2 Homo sapiens
-
5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8IWU9
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
brain
-
Homo sapiens
-
GH4-C1 cell pituitary cell line Rattus norvegicus
-
HEK-293 cell
-
Homo sapiens
-
L6 myoblast
-
Rattus norvegicus
-
RN-46A cell raphe cell line Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
-
Rattus norvegicus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
L-tryptophan + tetrahydrobiopterin + O2
-
Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Synonyms

Synonyms Comment Organism
TPH2
-
Rattus norvegicus
TPH2
-
Homo sapiens
tryptophan hydroxylase-2
-
Rattus norvegicus
tryptophan hydroxylase-2
-
Homo sapiens