EC Number   |
Activating Compound |
Reference |
|---|
    1.14.16.4 | DTT |
- |
675511, 684993, 688501, 688765, 688946, 689869 |
| 1.14.16.4 | Fe(NH4)2(SO4)2 |
- |
688946 |
| 1.14.16.4 | glutathione |
30 mM, 16.1% activity compared to activation with dithiothreitol |
671723 |
| 1.14.16.4 | L-cysteine |
- |
438658 |
| 1.14.16.4 | L-cysteine |
30 mM, 79.5% activity compared to activation with dithiothreitol |
671723 |
| 1.14.16.4 | more |
Acanthopanax senticosus, as aqueous extracts from fresh stem braks, increases the time to exhaustion by treadmill running and it suppressed the exercise-induced increase of 5-hydroxytryptamine synthesis and TPH expression. Acanthopanax senticosus is effective as caffeine for increasing the exhaustion time in treadmill running and for reducing the exercise-induced increase of 5-hydroxytryptamine synthesis and TPH expression in the dorsal raphe, overview |
688062 |
| 1.14.16.4 | more |
administration of 3,4-methylenedioxymethamphetamine to rats induces TPH1, but affects serotonin biosynthesis and TPH enzyme activity in dorsal raphe nuclei, and it decreases SERT binding sites in the striatum, nucleus accumbens and cingulate cortex demonstrating a loss of 5-hydroxytryptamine terminals, overview |
689232 |
| 1.14.16.4 | more |
citalopram raises basal extracellular serotonin levels in DBA/2J, DBA/2N and BALB/c mice carrying the 1473G allele, but not in C57BL/6J and C57BL/6N mice carrying the 1473C allele, overview |
688503 |
| 1.14.16.4 | more |
enzyme expression and activity are increased in hypoxic rats, the effect is partially reversed by 4-chlorophenylalanine and is reduced in TPH1-deficient rats, overview |
684359 |
| 1.14.16.4 | more |
fluoxetine treatment for 4 and 8 weeks significantly increases basal TPH2 mRNA levels in the midbrain, correlated with the appearance of antidepressant-like effects in the forced swim test, co-induction of TPH2 and the 5-hydroxytryptamine transporter expression, overview |
689230 |
