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Literature summary for 1.14.16.4 extracted from

  • Izikki, M.; Hanoun, N.; Marcos, E.; Savale, L.; Barlier-Mur, A.M.; Saurini, F.; Eddahibi, S.; Hamon, M.; Adnot, S.
    Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice (2007), Am. J. Physiol. Lung Cell. Mol. Physiol., 293, L1045-L1052.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information enzyme expression and activity are increased in hypoxic rats, the effect is partially reversed by 4-chlorophenylalanine and is reduced in TPH1-deficient rats, overview Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
genes Tph1 and Tph2, expression analysis in wild-type and mutant mice, overview Mus musculus

Protein Variants

Protein Variants Comment Organism
C1473G naturally occuring polymorphism of gene Tph2, C57Bl/6 and 129X1/SvJ mice are homozygous for the 1473C allele, whereas DBA/2 and BALB/cJ mice are homozygous for the 1473G allele, comparison of pulmonary hypertension and vascular remodeling of haplotypes, overview Mus musculus
additional information construction of Tph1 knockout mutant mice, distal pulmonary vessel muscularization is less marked in Tph1-/- than in wild-type mice Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
4-Chlorophenylalanine i.e. PCPA, potent inhibitor of TPH Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Mus musculus TPH is involved in 5-hydroxytryptamine biosynthesis 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
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?

Organism

Organism UniProt Comment Textmining
Mus musculus
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C57Bl/6, 129X1/SvJ, DBA/2, and BALB/cJ mice, genes Tph1 and Tph2 encoding isozymes TPH1 and TPH2, respectively
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Source Tissue

Source Tissue Comment Organism Textmining
blood
-
Mus musculus
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forebrain
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Mus musculus
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gut
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Mus musculus
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lung
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Mus musculus
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additional information tissue distribution and expression levels of TPH2 and TPH1 in normoxic and hypoxic wild-type and mutant mice, overview Mus musculus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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5-HT synthesis rates and tissue contents in normoxic mice harboring the C1473G polymorphism of the Tph2 gene, overview Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
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Mus musculus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
L-tryptophan + tetrahydrobiopterin + O2 TPH is involved in 5-hydroxytryptamine biosynthesis Mus musculus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Synonyms

Synonyms Comment Organism
TPH2
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Mus musculus
tryptophan hydroxylase 2
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Mus musculus