Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | enzyme expression and activity are increased in hypoxic rats, the effect is partially reversed by 4-chlorophenylalanine and is reduced in TPH1-deficient rats, overview | Mus musculus |
Cloned (Comment) | Organism |
---|---|
genes Tph1 and Tph2, expression analysis in wild-type and mutant mice, overview | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
C1473G | naturally occuring polymorphism of gene Tph2, C57Bl/6 and 129X1/SvJ mice are homozygous for the 1473C allele, whereas DBA/2 and BALB/cJ mice are homozygous for the 1473G allele, comparison of pulmonary hypertension and vascular remodeling of haplotypes, overview | Mus musculus |
additional information | construction of Tph1 knockout mutant mice, distal pulmonary vessel muscularization is less marked in Tph1-/- than in wild-type mice | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-Chlorophenylalanine | i.e. PCPA, potent inhibitor of TPH | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Mus musculus | TPH is involved in 5-hydroxytryptamine biosynthesis | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57Bl/6, 129X1/SvJ, DBA/2, and BALB/cJ mice, genes Tph1 and Tph2 encoding isozymes TPH1 and TPH2, respectively | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Mus musculus | - |
forebrain | - |
Mus musculus | - |
gut | - |
Mus musculus | - |
lung | - |
Mus musculus | - |
additional information | tissue distribution and expression levels of TPH2 and TPH1 in normoxic and hypoxic wild-type and mutant mice, overview | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
5-HT synthesis rates and tissue contents in normoxic mice harboring the C1473G polymorphism of the Tph2 gene, overview | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | - |
Mus musculus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | TPH is involved in 5-hydroxytryptamine biosynthesis | Mus musculus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPH2 | - |
Mus musculus |
tryptophan hydroxylase 2 | - |
Mus musculus |