Reference on EC 6.3.5.5 - carbamoyl-phosphate synthase (glutamine-hydrolysing) and Organism(s) Escherichia coli and UniProt Accession P00968
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
topREF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Meister, A.
Mechanism and regulation of the glutamine-dependent carbamyl phosphate synthetase of Escherichia coli
Adv. Enzymol. Relat. Areas Mol. Biol.
62
315-374
1989
Agaricus bisporus, Escherichia coli, Elasmobranchii, Fresh-water teleost, Mammalia, Squalus acanthias
Anderson, P.M.
Carbamoyl-phosphate synthetase: an example of effects on enzyme properties of shifting an equilibrium between active monomer and active oligomer
Biochemistry
25
5576-5582
1986
Escherichia coli
Kaseman, D.S.; Meister, A.
carbamyl phosphate synthetase (glutamine-utilizing) from Escherichia coli
Methods Enzymol.
113
305-326
1985
Escherichia coli, Escherichia coli B / ATCC 11303
Powers, S.G.; Griffith, O.W.; Meister, A.
Inhibition of carbamyl phosphate synthetase by P1,P5-di(adenosine 5')-pentaphosphate
J. Biol. Chem.
252
3558-3560
1977
Escherichia coli
Trotta, P.P; Estis, L.F.; Meister, A.; Haschemeyer, R.H.
Self-association and allosteric properties of glutamine-dependent carbamyl phosphate synthetase
J. Biol. Chem.
249
482-491
1974
Escherichia coli
Anderson, P.M.; Carlson, J.D.; Rosenthal, G.A.; Meister, A.
Effect of potassium cyanate on the catalytic activities of carbamyl phosphate synthetase
Biochem. Biophys. Res. Commun.
55
246-252
1973
Escherichia coli
Anderson, P.M.; Meister, A.
Evidence for an activated form of carbon dioxide in the reaction catalyzed by Escherichia coli carbamyl phosphate synthetase
Biochemistry
4
2803-2808
1965
Escherichia coli, Escherichia coli B / ATCC 11303
Rubio, V.; Llorente, P.
Activation of carbamoyl phosphate synthetase from Escherichia coli by glycerol
Biochem. Biophys. Res. Commun.
107
1400-1405
1982
Escherichia coli
Avid-Majd, F.; Stapleton, M.A.; Harmon, M.F.; Hanks, B.A.; Mullins, L.S.; Raushel, F.M.
Comparison of the functional differences for the homologous residues within the carboxy phosphate and carbamate domains of carbamoyl phosphate synthetase
Biochemistry
35
14362-14369
1996
Escherichia coli
Stapleton, M.A.; Javid-Majd, F.; Harmon, M.F.; Hanks, B.A.; Grahmann, J.L.; Mullins, L.S.; Raushel, F.M.
Role of conserved residues within the carboxy phosphate domain of carbamoyl phosphate synthetase
Biochemistry
35
14352-14361
1996
Escherichia coli
Czerwinski, R.M.; Mareya, S.M.; Raushel, F.M.
Regulatory changes in the control of carbamoyl phosphate synthetase induced by truncation and mutagenesis of the allosteric binding domain
Biochemistry
34
13920-13927
1995
Escherichia coli
Herve, G.; Nagy, M.; Le Gouar, M.; Penverne, B.; Ladjimi, M.
The carbamoyl phosphate synthetase-aspartate transcarbamoylase complex of Saccharomyces cerevisiae: molecular and cellular aspects
Biochem. Soc. Trans.
21
195-198
1993
Saccharomyces cerevisiae, Escherichia coli, eukaryota, Mesocricetus auratus
Guy, H.I.; Bouvier, A.; Evans, D.R.
The smallest carbamoyl-phosphate synthetase. A single catalytic subdomain catalyzes all three partial reactions
J. Biol. Chem.
14; 272
29255-29262
1997
Escherichia coli
Guy, H.I.; Rotgeri, A.; Evans, D.R.
Activation by fusion of the glutaminase and synthetase subunits of Escherichia coli carbamyl-phosphate synthetase
J. Biol. Chem.
272
19913-19918
1997
Escherichia coli
Pierrat, O.A.; Javid-Majd, F.; Raushel, F.M.
Dissection of the conduit for allosteric control of carbamoyl phosphate synthetase by ornithine
Arch. Biochem. Biophys.
400
26-33
2002
Escherichia coli
Thoden, J.B.; Miran, S.G.; Phillips, J.C.; Howard, A.J.; Raushel, F.M.; Holden, H.M.
Carbamoyl phosphate synthetase: caught in the act of glutamine hydrolysis
Biochemistry
37
8825-8831
1998
Escherichia coli
Braxton, B.L.; Mullins, L.S.; Raushel, F.M.; Reinhart, G.D.
Allosteric dominance in carbamoyl phosphate synthetase
Biochemistry
38
1394-1401
1999
Escherichia coli
Thoden, J.B.; Huang, X.; Raushel, F.M.; Holden, H.M.
The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway
Biochemistry
38
16158-16166
1999
Escherichia coli
Thoden, J.B.; Wesenberg, G.; Raushel, F.M.; Holden, H.M.
Carbamoyl phosphate synthetase: closure of the B-domain as a result of nucleotide binding
Biochemistry
38
2347-2357
1999
Escherichia coli
Bueso, J.; Cervera, J.; Fresquet, V.; Marina, A.; Lusty, C.J.; Rubio, V.
Photoaffinity labeling with the activator IMP and Site-Directed mutagenesis of histidine 995 of carbamoyl phosphate synthetase from Escherichia coli demonstrate that the binding site for IMP overlaps with that for the inhibitor UMP
Biochemistry
38
3910-3917
1999
Escherichia coli
Huang, X.; Raushel, F.M.
An engineered blockage within the ammonia tunnel of carbamoyl phosphate synthetase prevents the use of glutamine as a substrate but not ammonia
Biochemistry
39
3240-3247
2000
Escherichia coli
Miles, B.W.; Raushel, F.M.
Synchronization of the three reaction centers within carbamoyl Phosphate synthetase
Biochemistry
39
5051-5056
2000
Escherichia coli
Rishavy, M.A.; Cleland, W.W.; Lusty, C.J.
15N isotope effects in glutamine hydrolysis catalyzed by carbamyl phosphate synthetase: evidence for a tetrahedral intermediate in the mechanism
Biochemistry
39
7309-7315
2000
Escherichia coli
Kim, J.; Raushel, F.M.
Allosteric control of the oligomerization of carbamoyl phosphate synthetase from Escherichia coli
Biochemistry
40
11030-11036
2001
Escherichia coli
Kim, J.; Howell, S.; Huang, X.; Raushel, F.M.
Structural defects within the carbamate tunnel of carbamoyl phosphate synthetase
Biochemistry
41
12575-12581
2002
Escherichia coli
Nara, T.; Gao, G.; Yamasaki, H.; Nakajima-Shimada, J.; Aoki, T.
Carbamoyl-phosphate synthetase II in kinetoplastids
Biochim. Biophys. Acta
1387
462-468
1998
Dictyostelium discoideum, Drosophila melanogaster, Escherichia coli, Leishmania mexicana (O15829), Mesocricetus auratus, Saccharomyces cerevisiae, Trypanosoma cruzi (O15830)
Gibson, G.E.; Mullins, L.S.; Raushel, F.M.
Carbamoyl phosphate synthetase from Escherichia coli does not catalyze the dehydration of bicarbonate to carbon dioxide
Bioorg. Chem.
26
255-268
1998
Escherichia coli
-
Holden, H.M.; Thoden, J.B.; Raushel, F.M.
Carbamoyl phosphate synthetase: an amazing biochemical odyssey from substrate to product
Cell. Mol. Life Sci.
56
507-522
1999
Escherichia coli
Raushel, F.M.; Thoden, J.B.; Reinhart, G.D.; Holden, H.M.
Carbamoyl phosphate synthetase: a crooked path from substrates to products
Curr. Opin. Chem. Biol.
2
624-632
1998
Escherichia coli
Holden, H.M.; Thoden, J.B.; Raushel, F.M.
Carbamoyl phosphate synthetase: a tunnel runs through it
Curr. Opin. Struct. Biol.
8
679-685
1998
Escherichia coli
Mora, P.; Rubio, V.; Cervera, J.
Mechanism of oligomerization of Escherichia coli carbamoyl phosphate synthetase and modulation by the allosteric effectors. A site-directed mutagenesis study
FEBS Lett.
511
6-10
2002
Escherichia coli
Vaishnav, P.; Randev, S.; Jatiani, S.; Aggarwal, S.; Keharia, H.; Vyas, P.R.; Nareshkumar, G.; Archana, G.
Characterization of carbamoyl phosphate synthetase of Streptomyces spp
Indian J. Exp. Biol.
38
931-935
2000
Escherichia coli, Streptomyces coelicolor, Streptomyces lividans, Streptomyces lividans MTCC1
Guy, H.I.; Schmidt, B.; Herve, G.; Evans, D.R.
Pressure-induced dissociation of carbamoyl-phosphate synthetase domains. The catalytically active form is dimeric
J. Biol. Chem.
273
14172-14178
1998
Escherichia coli
Sahay, N.; Guy, H.I.; Liu, X.; Evans, D.R.
Regulation of an Escherichia coli/mammalian chimeric carbamoyl-phosphate synthetase
J. Biol. Chem.
273
31195-31202
1998
Escherichia coli, Mammalia
Thoden, J.B.; Raushel, F.M.; Wesenberg, G.; Holden, H.M.
The binding of inosine monophosphate to Escherichia coli carbamoyl phosphate synthetase
J. Biol. Chem.
274
22502-22507
1999
Escherichia coli
Hewagama, A.; Guy, H.I.; Vickrey, J.F.; Evans, D.R.
Functional linkage between the glutaminase and synthetase domains of carbamoyl-phosphate synthetase. Role of serine 44 in carbamoyl-phosphate synthetase-aspartate carbamoyltransferase-dihydroorotase (CAD)
J. Biol. Chem.
274
28240-28245
1999
Escherichia coli, Mammalia
Huang, X.; Raushel, F.M.
Restricted passage of reaction intermediates through the ammonia tunnel of carbamoyl phosphate synthetase
J. Biol. Chem.
275
26233-26240
2000
Escherichia coli
Ahuja, A.; Purcarea, C.; Guy, H.I.; Evans, D.R.
A novel carbamoyl-phosphate synthetase from Aquifex aeolicus
J. Biol. Chem.
276
45694-45703
2001
Aquifex aeolicus, Bacillus subtilis, Cricetinae, Escherichia coli, Methanocaldococcus jannaschii, Pseudomonas aeruginosa
Eroglu, B.; Powers-Lee, S.G.
Unmasking a functional allosteric domain in an allosterically nonresponsive carbamoyl-phosphate synthetase
J. Biol. Chem.
277
45466-45472
2002
Saccharomyces cerevisiae, Escherichia coli
Saeed-Kothe, A.; Powers-Lee, S.G.
Specificity determining residues in ammonia- and glutamine-dependent carbamoyl phosphate synthetases
J. Biol. Chem.
277
7231-7238
2002
Escherichia coli
Saeed-Kothe, A.; Powers-Lee, S.G.
Gain of glutaminase function in mutants of the ammonia-specific frog carbamoyl phosphate synthetase
J. Biol. Chem.
278
26722-26726
2003
Escherichia coli
Delannay, S.; Charlier, D.; Tricot, C.; Villeret, V.; Pierard, A.; Stalon, V.
Serine 948 and threonine 1042 are crucial residues for allosteric regulation of Escherichia coli carbamoylphosphate synthetase and illustrate coupling effects of activation and inhibition pathways
J. Mol. Biol.
286
1217-1228
1999
Escherichia coli
Fresquet, V.; Mora, P.; Rochera, L.; Ramon-Maiques, S.; Rubio, V.; Cervera, J.
Site-directed mutagenesis of the regulatory domain of Escherichia coli carbamoyl phosphate synthetase identifies crucial residues for allosteric regulation and for transduction of the regulatory signals
J. Mol. Biol.
299
979-991
2000
Escherichia coli, Escherichia coli L814
Kim, J.; Raushel, F.M.
Access to the carbamate tunnel of carbamoyl phosphate synthetase
Arch. Biochem. Biophys.
425
33-41
2004
Escherichia coli
Kim, J.; Raushel, F.M.
Perforation of the tunnel wall in carbamoyl phosphate synthetase derails the passage of ammonia between sequential active sites
Biochemistry
43
5334-5340
2004
Escherichia coli
Yefimenko, I.; Fresquet, V.; Marco-Marin, C.; Rubio, V.; Cervera, J.
Understanding carbamoyl phosphate synthetase deficiency: impact of clinical mutations on enzyme functionality
J. Mol. Biol.
349
127-141
2005
Escherichia coli
Thoden, J.B.; Huang, X.; Kim, J.; Raushel, F.M.; Holden, H.M.
Long-range allosteric transitions in carbamoyl phosphate synthetase
Protein Sci.
13
2398-2405
2004
Escherichia coli
Kothe, M.; Powers-Lee, S.G.
Nucleotide recognition in the ATP-grasp protein carbamoyl phosphate synthetase
Protein Sci.
13
466-475
2004
Escherichia coli
Johnson, J.L.; West, J.K.; Nelson, A.D.; Reinhart, G.D.
Resolving the fluorescence response of Escherichia coli carbamoyl phosphate synthetase: mapping intra- and intersubunit conformational changes
Biochemistry
46
387-397
2007
Escherichia coli
Devroede, N.; Huysveld, N.; Charlier, D.
Mutational analysis of intervening sequences connecting the binding sites for integration host factor, PepA, PurR, and RNA polymerase in the control region of the Escherichia coli carAB operon, encoding carbamoylphosphate synthase
J. Bacteriol.
188
3236-3245
2006
Escherichia coli
Fan, Y.; Lund, L.; Yang, L.; Raushel, F.M.; Gao, Y.Q.
Mechanism for the transport of ammonia within carbamoyl phosphate synthetase determined by molecular dynamics simulations
Biochemistry
47
2935-2944
2008
Escherichia coli
Hart, E.J.; Powers-Lee, S.G.
Role of Cys1327 and Cys1337 in redox sensitivity and allosteric monitoring in human carbamoyl phosphate synthetase
J. Biol. Chem.
284
5977-5985
2008
Escherichia coli
Hart, E.J.; Powers-Lee, S.G.
Mutation analysis of carbamoyl phosphate synthetase: does the structurally conserved glutamine amidotransferase triad act as a functional dyad?
Protein Sci.
17
1120-1128
2008
Escherichia coli
Fan, Y.; Lund, L.; Shao, Q.; Gao, Y.Q.; Raushel, F.M.
A combined theoretical and experimental study of the ammonia tunnel in carbamoyl phosphate synthetase
J. Am. Chem. Soc.
131
10211-10219
2009
Escherichia coli
