Activating Compound | Comment | Organism | Structure |
---|---|---|---|
5-phospho-alpha-D-ribosyl 1-diphosphate | stimulates | Mesocricetus auratus | |
phosphate | multifunctional proteins are phosphorylated in vivo and in vitro. This covalent modification has only a small effect on the enzymic activity, and might be a signal for protein degradation | Saccharomyces cerevisiae | |
phosphate | multifunctional proteins are phosphorylated in vivo and in vitro. This covalent modification has only a small effect on the enzymic activity, and might be a signal for protein degradation | Mesocricetus auratus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
UMP | feedback inhibition | Escherichia coli | |
UTP | - |
Escherichia coli | |
UTP | feed-back inhibition | Mesocricetus auratus | |
UTP | feed-back inhibition | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | carbamoyl-phosphate-synthase/aspartate-transcarbamoylase complex | Saccharomyces cerevisiae | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
eukaryota | - |
possess 2 carbamoyl-phosphate synthases, one belonging to the arginine pathway, CPSase-A, and another belonging to the pyrimidine pathway, CPSase-P | - |
Mesocricetus auratus | - |
multifunctional protein, catalyzing the first three steps in de novo pyrimidine biosynthesis | - |
Saccharomyces cerevisiae | - |
carbamoyl-phosphate-synthase/aspartate transcarbamoylase complex | - |
Purification (Comment) | Organism |
---|---|
- |
Saccharomyces cerevisiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ATP + L-Gln + HCO3- | - |
eukaryota | 2 ADP + phosphate + L-Glu + carbamoyl phosphate | - |
? | |
2 ATP + L-Gln + HCO3- | - |
Escherichia coli | 2 ADP + phosphate + L-Glu + carbamoyl phosphate | - |
? | |
2 ATP + L-Gln + HCO3- | - |
Saccharomyces cerevisiae | 2 ADP + phosphate + L-Glu + carbamoyl phosphate | - |
? | |
2 ATP + L-Gln + HCO3- | - |
Mesocricetus auratus | 2 ADP + phosphate + L-Glu + carbamoyl phosphate | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
IMP | stimulates | Escherichia coli |