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UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose
UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose
-
-
-
-
UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose
catalytic mechanism, overview
-
UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose
mobile loop of enzyme must move in order for enzyme to bind UDP-galactose substrate
UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose
chemical reaction mechanism, overview
-
UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose
chemical reaction mechanism, overview
-
UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose
chemical reaction mechanism, overview
-
UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose
chemical reaction mechanism, overview
-
UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose
chemical reaction mechanism, overview
-
UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose
reaction mechanism, overview. FAD-UDP-alpha-D-galactopyranose/UDP-alpha-D-galactofuranose adduct as an intermediate in the catalytic cycle, the chemical mechanism for UGM involves an SN2-type displacement of UDP from UDP-alpha-D-galactopyranose/UDP-alpha-D-galactofuranose by N5 of FADred
-
UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose
catalytic reaction mechanism, detailed overview. A covalent adduct is formed between the substrate and the FADH cofactor, temporarily breaking the glycosidic bond, followed by an internal proton transfer between N5FADH and O6FADH. The next step involves linearization of the sugar and formation of the iminium ion species. In the next step, the sugar cyclizes into its five-membered ring form. This step is isotope sensitive and is considered to be the chemical rate-limiting step of the mechanism. Once the furanose form of the sugar is reached, another internal proton transfer takes place, and the glycosidic bond to UDP is formed. Finally, the product of the reaction exits the active site of the enzyme
UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose
detailed reaction mechanism involving SN2-type steps, overview
-
UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose
enzyme-substrate binding structure and mechanism
UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose
quantum mechanics-molecular mechanics (QM/MM) molecular dynamics study and reaction mechanism, characterization of the structures of reactants, products, intermediate species and transitions states, overview
-
UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose
reaction mechanism including FAD cofactor, overview. Role of a covalent flavin N5 intermediate in the isomerization, non-redox reaction, of UDP-galactopyranose (UDP-Galp) to UDP-galactofuranose (UDP-Galf) by UDP-galactopyranose mutase (UGM). The flavin is required to be in the reduced state and functions as a nucleophile. The flavin must cycle back to the oxidized state for sustained catalysis. Formation of a N5-iminium ion intermediate, Fformation of N5-adducts in non-redox reactions involving the flavin in the oxidized or reduced forms
UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose
chemical reaction mechanism, overview
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-
UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose
catalytic mechanism, overview
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2-fluoro-deoxy-UDP-galactopyranose
2-fluoro-deoxy-UDP-galactofuranose
-
-
-
?
UDP-(6-deoxy-6-fluoro)-D-galactofuranose
?
-
-
-
-
?
UDP-(6-deoxy-6-fluoro)-D-galactofuranose
UDP-(6-deoxy-6-fluoro)-D-galactopyranose
-
-
-
-
r
UDP-2,3-dideoxy-2,2,3,3-tetrafluoro-alpha-D-galactopyranose
UDP-2,3-dideoxy-2,2,3,3-tetrafluoro-alpha-D-galactofuranose
-
-
-
r
UDP-2-amino-2-deoxy-D-galactopyranose
?
-
-
-
-
?
UDP-2-deoxy-2-fluoro-D-galactofuranose
?
-
-
-
-
?
UDP-2-deoxy-2-fluoro-D-galactopyranose
?
-
-
-
-
?
UDP-2-fluoro-galactofuranose
?
-
-
-
-
?
UDP-3''-deoxy-3''-fluoro-D-galactopyranose
UDP-3''-deoxy-3''-fluoro-D-galactofuranose
-
-
-
r
UDP-3-deoxy-3-fluoro-D-galactofuranose
?
UDP-3-deoxy-3-fluoro-D-galactopyranose
?
-
-
-
-
?
UDP-6-deoxy-6-fluoro-D-galactopyranose
?
-
-
-
-
?
UDP-6-deoxy-D-galactopyranose
?
-
-
-
-
?
UDP-alpha-D-galactofuranose
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
UDP-beta-L-arabinofuranose
?
-
-
-
-
?
UDP-beta-L-arabinofuranose
UDP-beta-L-arabinopyranose
-
-
-
r
UDP-beta-L-arabinopyranose
UDP-beta-L-arabinofuranose
-
-
-
r
UDP-D-galactofuranose
UDP-D-galactopyranose
UDP-D-galactopyranose
UDP-D-galactofuranose
UDP-galactofuranose
UDP-galactopyranose
UDP-galactopyranose
UDP-galactofuranose
UDP-L-arabinofuranose
?
-
-
-
-
?
UDP-N-acetyl-2-deoxy-2-amino-alpha-D-galactopyranose
UDP-N-acetyl-2-deoxy-2-amino-alpha-D-galactofuranose
Uridine 5'-(trihydrogen diphosphate) P'-alpha-D-galactopyranosyl ester
Uridine 5'-(trihydrogen diphosphate) P'-alpha-D-galactofuranosyl ester
-
-
-
?
additional information
?
-
UDP-3-deoxy-3-fluoro-D-galactofuranose
?
-
-
-
-
?
UDP-3-deoxy-3-fluoro-D-galactofuranose
?
-
-
-
-
?
UDP-alpha-D-galactofuranose
UDP-alpha-D-galactopyranose
-
-
-
r
UDP-alpha-D-galactofuranose
UDP-alpha-D-galactopyranose
-
-
-
-
r
UDP-alpha-D-galactofuranose
UDP-alpha-D-galactopyranose
-
-
-
-
r
UDP-alpha-D-galactofuranose
UDP-alpha-D-galactopyranose
-
UGM-catalyzed interconversion
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-
r
UDP-alpha-D-galactofuranose
UDP-alpha-D-galactopyranose
-
-
-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
-
-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
-
-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
-
-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
the equilibrium of the UGM-catalyzed reaction favors UDP-Galp by the ratio of 11:1
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r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
-
-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
-
-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
-
-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
-
-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
-
-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
the equilibrium of the UGM-catalyzed reaction favors UDP-Galp by the ratio of 11:1
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-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
-
-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
the equilibrium of the UGM-catalyzed reaction favors UDP-Galp by the ratio of 11:1
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-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
-
-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
the equilibrium of the UGM-catalyzed reaction favors UDP-Galp by the ratio of 11:1
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-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
-
-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
the equilibrium of the UGM-catalyzed reaction favors UDP-Galp by the ratio of 11:1
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r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
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r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
the equilibrium of the UGM-catalyzed reaction favors UDP-Galp by the ratio of 11:1
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r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
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r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
the equilibrium of the UGM-catalyzed reaction favors UDP-Galp by the ratio of 11:1
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r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
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r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
the equilibrium of the UGM-catalyzed reaction favors UDP-Galp by the ratio of 11:1
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r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
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r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
the equilibrium of the UGM-catalyzed reaction favors UDP-Galp by the ratio of 11:1
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r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
substrate binding structure of wild-type and mutant P306R, three-dimensional structure of the reduced MtUGM:UDP-Galp dimer, detailed overview. Substrate binding induces local changes in MtUGM active site
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r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
UGM-catalyzed interconversion
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r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
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-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
-
-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
the equilibrium of the UGM-catalyzed reaction favors UDP-Galp by the ratio of 11:1
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-
r
UDP-alpha-D-galactopyranose
UDP-alpha-D-galactofuranose
-
via iminium ion intermediates
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-
r
UDP-D-galactofuranose
UDP-D-galactopyranose
-
-
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-
r
UDP-D-galactofuranose
UDP-D-galactopyranose
-
-
-
-
r
UDP-D-galactofuranose
UDP-D-galactopyranose
-
-
-
-
r
UDP-D-galactopyranose
UDP-D-galactofuranose
-
-
-
-
r
UDP-D-galactopyranose
UDP-D-galactofuranose
-
-
-
-
r
UDP-D-galactopyranose
UDP-D-galactofuranose
-
-
-
r
UDP-D-galactopyranose
UDP-D-galactofuranose
-
-
-
?
UDP-D-galactopyranose
UDP-D-galactofuranose
-
-
-
-
?
UDP-D-galactopyranose
UDP-D-galactofuranose
-
-
-
-
r
UDP-D-galactopyranose
UDP-D-galactofuranose
-
-
-
?
UDP-D-galactopyranose
UDP-D-galactofuranose
-
-
-
-
r
UDP-D-galactopyranose
UDP-D-galactofuranose
-
-
-
-
?
UDP-D-galactopyranose
UDP-D-galactofuranose
-
-
-
-
r
UDP-D-galactopyranose
UDP-D-galactofuranose
-
-
-
-
?
UDP-galactofuranose
UDP-galactopyranose
-
-
8-5% product yield, 92-95% product yield
-
r
UDP-galactofuranose
UDP-galactopyranose
-
-
8-5% product yield, 92-95% product yield
-
r
UDP-galactopyranose
UDP-galactofuranose
-
-
-
?
UDP-galactopyranose
UDP-galactofuranose
-
-
-
r
UDP-galactopyranose
UDP-galactofuranose
-
-
-
-
?
UDP-galactopyranose
UDP-galactofuranose
-
-
-
-
?
UDP-galactopyranose
UDP-galactofuranose
-
-
-
-
?
UDP-galactopyranose
UDP-galactofuranose
-
-
-
-
r
UDP-galactopyranose
UDP-galactofuranose
-
pH 7.1, 30°C
-
-
r
UDP-galactopyranose
UDP-galactofuranose
-
-
-
-
?
UDP-galactopyranose
UDP-galactofuranose
-
-
-
-
?
UDP-galactopyranose
UDP-galactofuranose
-
-
-
r
UDP-galactopyranose
UDP-galactofuranose
pH 7.1, 30°C
-
-
r
UDP-galactopyranose
UDP-galactofuranose
-
-
-
-
r
UDP-galactopyranose
UDP-galactofuranose
-
-
-
?
UDP-galactopyranose
UDP-galactofuranose
-
-
-
?
UDP-galactopyranose
UDP-galactofuranose
-
-
-
-
?
UDP-galactopyranose
UDP-galactofuranose
-
-
-
-
r
UDP-galactopyranose
UDP-galactofuranose
-
-
?
UDP-galactopyranose
UDP-galactofuranose
-
-
-
?
UDP-galactopyranose
UDP-galactofuranose
-
-
-
-
?
UDP-galactopyranose
UDP-galactofuranose
-
-
-
-
r
UDP-galactopyranose
UDP-galactofuranose
-
-
-
r
UDP-galactopyranose
UDP-galactofuranose
-
-
-
-
r
UDP-galactopyranose
UDP-galactofuranose
-
-
-
r
UDP-galactopyranose
UDP-galactofuranose
pH 7.1, 30°C
-
-
r
UDP-galactopyranose
UDP-galactofuranose
-
-
-
-
?
UDP-galactopyranose
UDP-galactofuranose
-
-
-
-
r
UDP-galactopyranose
UDP-galactofuranose
-
-
-
r
UDP-galactopyranose
UDP-galactofuranose
-
essential step of mycobacterial cell wall biosynthesis
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-
r
UDP-galactopyranose
UDP-galactofuranose
-
-
-
-
r
UDP-galactopyranose
UDP-galactofuranose
-
-
-
r
UDP-galactopyranose
UDP-galactofuranose
pH 7.1, 30°C
-
-
r
UDP-N-acetyl-2-deoxy-2-amino-alpha-D-galactopyranose
UDP-N-acetyl-2-deoxy-2-amino-alpha-D-galactofuranose
-
-
-
-
r
UDP-N-acetyl-2-deoxy-2-amino-alpha-D-galactopyranose
UDP-N-acetyl-2-deoxy-2-amino-alpha-D-galactofuranose
-
-
-
-
r
additional information
?
-
-
the enzyme is active in the oxidized state, being 2-3fold less active than in the reduced state. In the oxidized state, UGM does not bind UDP-galactopyranose
-
-
?
additional information
?
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-
development of a fluorescence polarization binding assay for the Aspergillus fumigatus enzyme, evaluation, overview
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-
?
additional information
?
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active site and substrate binding structure, overview, the UDP exosite is located at a junction between domains 1 and 3
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-
?
additional information
?
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active site and substrate binding structure, overview, the UDP exosite is located at a junction between domains 1 and 3
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-
?
additional information
?
-
-
UDP-galactopyranose mutase as an important protein in fungal cell wall biosynthesis
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-
?
additional information
?
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-
UDP-galactopyranose mutase as an important protein in fungal cell wall biosynthesis
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-
?
additional information
?
-
-
UGM does not interconvert UDP-GalpNAc and UDP-GalfNAc
-
-
?
additional information
?
-
-
the bifunctional pyranose-furanose mutase recognizes both UDP-Gal and UDP-GalNAc
-
-
?
additional information
?
-
-
the bifunctional pyranose-furanose mutase recognizes both UDP-Gal and UDP-GalNAc
-
-
?
additional information
?
-
-
UGM does not interconvert UDP-GalpNAc and UDP-GalfNAc
-
-
?
additional information
?
-
-
no activity with UDP-6-deoxy-Dgalactopyranose, UDP-2-azido-2-deoxy-D-galactopyranose, and UDP-2-acetamido-2-deoxy-D-galactopyranose
-
-
?
additional information
?
-
UDP-D-glucose is not a substrate for UGM
-
-
?
additional information
?
-
-
UDP-D-glucose is not a substrate for UGM
-
-
?
additional information
?
-
-
the enzyme is active only in the reduced state
-
-
?
additional information
?
-
-
1,4-anhydrogalactopyranose does not react with UGM and UDP to form UDP-galactopyranose or UDP-galactofuranose
-
-
?
additional information
?
-
analysis of the structural basis of ligand binding to UDP-galactopyranose mutase from Mycobacterium tuberculosis using substrate and tetrafluorinated substrate analogues, overview
-
-
?
additional information
?
-
-
analysis of the structural basis of ligand binding to UDP-galactopyranose mutase from Mycobacterium tuberculosis using substrate and tetrafluorinated substrate analogues, overview
-
-
?
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5.4.99.9 UDP-galactopyranose mutase
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