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BRENDA support

Information on EC 5.4.3.3 - lysine 5,6-aminomutase

for references in articles please use BRENDA:EC5.4.3.3

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IUBMB Comments

This enzyme is a member of the ‘AdoMet radical’ (radical SAM) family. It requires pyridoxal 5′-phosphate and adenosylcobalamin for activity. A 5′-deoxyadenosyl radical is generated during the reaction cycle by reductive cleavage of adenosylcobalamin, which is regenerated at the end of the reaction.

The expected taxonomic range for this enzyme is: Bacteria, Archaea

Synonyms
lysine 5,6-aminomutase, 5,6-lam, kamde, d-lysine 5,6-aminomutase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate
show the reaction diagram
D-lysine = (2R,5S)-2,5-diaminohexanoate
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
L-lysine fermentation to acetate and butanoate