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Literature summary for 5.4.3.3 extracted from
- Pyridoxal-5'-phosphate as the catalyst for radical isomerization in reactions of PLP-dependent aminomutases (2011), Biochim. Biophys. Acta, 1814, 1548-1557.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Acetoanaerobium sticklandii | - |
- |
- |
| Porphyromonas gingivalis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (R)-lysine | best substrate | Porphyromonas gingivalis | ? | - |
? |  |
| (S)-beta-lysine | - |
Acetoanaerobium sticklandii | 3,5-diaminohexanoate | - |
r | |
| (S)-beta-lysine | - |
Porphyromonas gingivalis | 3,5-diaminohexanoate | - |
r | |
| (S)-lysine | - |
Porphyromonas gingivalis | ? | - |
? | |
| 4-thia-(R)-lysine | 4-thia-(R)-lysine reacts with the complex of pyridoxal 5'-phosphate, adenosylcobalamin, and lysine 5,6-aminomutase to generate cob(II)alamin, 5'-deoxyadenosine, and 4-thialysine-based free radicals | Acetoanaerobium sticklandii | ? | - |
? | |
| 4-thia-(S)-lysine | 4-thia-(S)-lysine reacts with the complex of pyridoxal 5'-phosphate, adenosylcobalamin, and lysine 5,6-aminomutase to generate cob(II)alamin, 5'-deoxyadenosine, and 4-thialysine-based free radicals | Acetoanaerobium sticklandii | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | - |
Acetoanaerobium sticklandii |
| heterodimer | - |
Porphyromonas gingivalis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| (R)-lysine mutase | formerly | Acetoanaerobium sticklandii |
| (R)-lysine mutase | formerly | Porphyromonas gingivalis |
| beta-Lysine mutase | - |
Acetoanaerobium sticklandii |
| beta-Lysine mutase | - |
Porphyromonas gingivalis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| adenosylcobalamin | - |
Acetoanaerobium sticklandii | |
| adenosylcobalamin | - |
Porphyromonas gingivalis | |
| pyridoxal 5'-phosphate | - |
Acetoanaerobium sticklandii | |
| pyridoxal 5'-phosphate | - |
Porphyromonas gingivalis | |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00043 | - |
(S)-lysine | pH and temperature not specified in the publication | Porphyromonas gingivalis | |
| 0.48 | - |
(S)-beta-lysine | pH and temperature not specified in the publication | Porphyromonas gingivalis | |
| 0.63 | - |
(R)-lysine | pH and temperature not specified in the publication | Porphyromonas gingivalis | |
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Release 2023.1 (January 2023)
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