Protein Variants | Comment | Organism |
---|---|---|
Y263F | the mutation abolishes the enzymatic activity | Acetoanaerobium sticklandii |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(3S)-3,6-diaminohexanoate | Acetoanaerobium sticklandii | - |
(3S,5S)-3,5-diaminohexanoate | - |
r | |
D-lysine | Acetoanaerobium sticklandii | - |
2,5-diaminohexanoate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Acetoanaerobium sticklandii | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
(3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate | radical stabilization is crucial in the mechanism of action of lysine 5,6-aminomutase, role of Tyr263alpha. The enzyme utilizes free radical intermediates to mediate 1,2-amino group rearrangement, during which an elusive high-energy aziridincarbinyl radical is proposed to be central in the mechanism of action. The aziridincarbinyl radical acts either as a spin-relay device or serves as an anchor for the pyridine ring of pyridoxal-5' -phosphate through aromatic PI-stacking interactions during spin transfer, detailed overview | Acetoanaerobium sticklandii | |
D-lysine = (2R,5S)-2,5-diaminohexanoate | radical stabilization is crucial in the mechanism of action of lysine 5,6-aminomutase, role of Tyr263alpha. The enzyme utilizes free radical intermediates to mediate 1,2-amino group rearrangement, during which an elusive high-energy aziridincarbinyl radical is proposed to be central in the mechanism of action. The aziridincarbinyl radical acts either as a spin-relay device or serves as an anchor for the pyridine ring of pyridoxal-5' -phosphate through aromatic PI-stacking interactions during spin transfer, detailed overview | Acetoanaerobium sticklandii |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(3S)-3,6-diaminohexanoate | - |
Acetoanaerobium sticklandii | (3S,5S)-3,5-diaminohexanoate | - |
r | |
D-lysine | - |
Acetoanaerobium sticklandii | 2,5-diaminohexanoate | - |
r | |
additional information | the enzyme can accept D-lysine and L-beta-lysine | Acetoanaerobium sticklandii | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | alpha2beta2 | Acetoanaerobium sticklandii |
Synonyms | Comment | Organism |
---|---|---|
5,6-LAM | - |
Acetoanaerobium sticklandii |
lysine 5,6-aminomutase | - |
Acetoanaerobium sticklandii |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
5'-deoxyadenosylcobalamin | dependent on | Acetoanaerobium sticklandii | |
pyridoxal 5'-phosphate | dependent on | Acetoanaerobium sticklandii |