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Literature summary for 5.4.3.3 extracted from

  • Maity, A.; Ke, S.
    5-Fluorolysine as alternative substrate of lysine 5,6-aminomutase: A computational study (2013), Comp. Theoret. Chem., 1022, 1-5.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(3S)-3,6-diaminohexanoate Acetoanaerobium sticklandii
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(3S,5S)-3,5-diaminohexanoate
-
r

Organism

Organism UniProt Comment Textmining
Acetoanaerobium sticklandii
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-
-

Reaction

Reaction Comment Organism Reaction ID
(3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate radical catalytic mechanism Acetoanaerobium sticklandii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(3S)-3,6-diaminohexanoate
-
Acetoanaerobium sticklandii (3S,5S)-3,5-diaminohexanoate
-
r
additional information 5-fluorolysine as substrate binding in the active site: computational simulations, the enzyme 5,6-LAM abstracts the hydrogen atom rather than the fluorine at C5 of 5-fluorolysine and subsequent rearrangement mimicking the similar mechanism as the natural substrate of the enzyme Acetoanaerobium sticklandii ?
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?

Synonyms

Synonyms Comment Organism
5,6-LAM
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Acetoanaerobium sticklandii
lysine 5,6-aminomutase
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Acetoanaerobium sticklandii

Cofactor

Cofactor Comment Organism Structure
5'-deoxyadenosylcobalamin dependent on Acetoanaerobium sticklandii
pyridoxal 5'-phosphate dependent on, molecular modeling in the reaction Acetoanaerobium sticklandii