Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(3S)-3,6-diaminohexanoate | Acetoanaerobium sticklandii | - |
(3S,5S)-3,5-diaminohexanoate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Acetoanaerobium sticklandii | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
(3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate | radical catalytic mechanism | Acetoanaerobium sticklandii |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(3S)-3,6-diaminohexanoate | - |
Acetoanaerobium sticklandii | (3S,5S)-3,5-diaminohexanoate | - |
r | |
additional information | 5-fluorolysine as substrate binding in the active site: computational simulations, the enzyme 5,6-LAM abstracts the hydrogen atom rather than the fluorine at C5 of 5-fluorolysine and subsequent rearrangement mimicking the similar mechanism as the natural substrate of the enzyme | Acetoanaerobium sticklandii | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
5,6-LAM | - |
Acetoanaerobium sticklandii |
lysine 5,6-aminomutase | - |
Acetoanaerobium sticklandii |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
5'-deoxyadenosylcobalamin | dependent on | Acetoanaerobium sticklandii | |
pyridoxal 5'-phosphate | dependent on, molecular modeling in the reaction | Acetoanaerobium sticklandii |