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Literature summary for 5.4.3.3 extracted from

  • Morley, C.G.D.; Stadtman, T.C.
    Studies on the fermentation of D-alpha-lysine. Purification and properties of an adenosine triphosphate regulated B12-coenzyme-dependent D-alpha-lysine mutase complex from Clostridium sticklandii (1970), Biochemistry, 9, 4890-4900.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
mercaptan required Acetoanaerobium sticklandii

General Stability

General Stability Organism
inactivated by irradiation Acetoanaerobium sticklandii

Inhibitors

Inhibitors Comment Organism Structure
1,4-diaminobutane
-
Acetoanaerobium sticklandii
2-amino-n-butanoate
-
Acetoanaerobium sticklandii
2-amino-n-pentanoic acid
-
Acetoanaerobium sticklandii
2-aminoisobutanoate
-
Acetoanaerobium sticklandii
3-amino-n-butanoate
-
Acetoanaerobium sticklandii
3-aminoisobutanoate
-
Acetoanaerobium sticklandii
4-amino-n-butanoate
-
Acetoanaerobium sticklandii
6-amino-n-hexanoic acid
-
Acetoanaerobium sticklandii
acetate
-
Acetoanaerobium sticklandii
Butyrate
-
Acetoanaerobium sticklandii
DL-citrulline
-
Acetoanaerobium sticklandii
DL-delta-hydroxylysine
-
Acetoanaerobium sticklandii
DL-epsilon-N-Acetyllysine
-
Acetoanaerobium sticklandii
DL-Pro
-
Acetoanaerobium sticklandii
iodoacetamide
-
Acetoanaerobium sticklandii
L-2,4-diamino-n-butyrate
-
Acetoanaerobium sticklandii
L-beta-Lysine
-
Acetoanaerobium sticklandii
L-Ile
-
Acetoanaerobium sticklandii
L-Orn
-
Acetoanaerobium sticklandii
n-Hexanoate
-
Acetoanaerobium sticklandii
S-aminoethylcysteine
-
Acetoanaerobium sticklandii

Metals/Ions

Metals/Ions Comment Organism Structure
K+ stimulation by monovalent cations, K+ or NH4+ Acetoanaerobium sticklandii
Mg2+ stimulates Acetoanaerobium sticklandii
NH4+ stimulation by monovalent cations, K+ or NH4+ Acetoanaerobium sticklandii

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
250000
-
gel filtration Acetoanaerobium sticklandii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-alpha-Lysine Acetoanaerobium sticklandii enzyme of lysine fermentation pathway ?
-
?

Organism

Organism UniProt Comment Textmining
Acetoanaerobium sticklandii
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Acetoanaerobium sticklandii

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.08
-
-
Acetoanaerobium sticklandii

Storage Stability

Storage Stability Organism
-15°C, Tris buffer, pH 8.5-9.0, protein concentration of no less than 3 mg/ml, 20-40% loss of activity after 1 month Acetoanaerobium sticklandii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-alpha-Lysine
-
Acetoanaerobium sticklandii 2,5-Diaminohexanoate
-
?
D-alpha-Lysine enzyme of lysine fermentation pathway Acetoanaerobium sticklandii ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9 9.2 Tris/HCl buffer Acetoanaerobium sticklandii

pH Range

pH Minimum pH Maximum Comment Organism
8 10.5 pH 8.0: about 55% of maximal activity, pH 10.5: about 65% of maximal activity, no activity at pH 7 Acetoanaerobium sticklandii

pH Stability

pH Stability pH Stability Maximum Comment Organism
4
-
dissociation of complex Acetoanaerobium sticklandii

Cofactor

Cofactor Comment Organism Structure
ATP or phosphonic acid analogs, stimulates, allosteric effector Acetoanaerobium sticklandii
Cobalamin required Acetoanaerobium sticklandii
pyridoxal 5'-phosphate required Acetoanaerobium sticklandii