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Reference on EC 3.5.4.1 - cytosine deaminase and Organism(s) Saccharomyces cerevisiae and UniProt Accession Q12178

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ipata, P.L.; Marmocchi, F.; Magni, G.; Felicioli, R.; Polidoro, G.
Baker's yeast cytosine deaminase. Some enzymic properties and allosteric inhibition by nucleosides and nucleotides
Biochemistry
10
4270-4276
1971
Saccharomyces cerevisiae, Escherichia coli
Manually annotated by BRENDA team
Balestreri, E.; Felicioli, R.A.; Ipata, P.L.
The effect of pH on the alosteric properties of baker's yeast cytosine deaminase
Biochim. Biophys. Acta
293
443-448
1973
Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Holldorf, A.W.
Cytosine
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
3
1964-1966
1974
Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Sakai, T.; Yu, T.; Tabe, H.; Omata, S.
Purification of cytosine deaminase from Serratia marcescens
Agric. Biol. Chem.
39
1623-1629
1975
Saccharomyces cerevisiae, Escherichia coli, Serratia marcescens
-
Manually annotated by BRENDA team
Sakai, T.; Yu, T.; Taniguchi, K.; Omata, S.
Purification of cytosine deaminase from Pseudomonas aureofaciens
Agric. Biol. Chem.
39
2015-2020
1975
Klebsiella aerogenes, Enterobacter cloacae, Alcaligenes faecalis, Bacillus subtilis, Saccharomyces cerevisiae, Citrobacter freundii, Escherichia coli, Micrococcus flavus, Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas chlororaphis subsp. aureofaciens, Pseudomonas chlororaphis, Pseudomonas cruciviae, Pseudomonas fluorescens, Pseudomonas fragi, Pseudomonas schuylkilliensis, Ralstonia solanacearum, Pseudomonas coronafaciens pv. striafaciens, Pseudomonas taetrolens, Pseudomonas trifolii, Serratia marcescens, Serratia polymuthicum, Alcaligenes faecalis type S, Serratia marcescens type S, Enterobacter cloacae IAM 1221, Pseudomonas schuylkilliensis type S, Escherichia coli K12 AKU 0005, Pseudomonas chlororaphis type S, Proteus vulgaris type S, Pseudomonas aeruginosa type S, Pseudomonas putida type S, Proteus mirabilis type S, Pseudomonas trifolii type S, Enterobacter cloacae type S, Alcaligenes faecalis AKU 0101, Serratia polymuthicum AKU 0062, Pseudomonas cruciviae type S, Micrococcus flavus AKU 0502, Klebsiella aerogenes type S, Ralstonia solanacearum type S
-
Manually annotated by BRENDA team
Yu, T.; Sakai, T.; Omata, S.
Kinetic properties of cytosine deaminase from Serratia marcescens
Agric. Biol. Chem.
40
543-549
1976
Saccharomyces cerevisiae, Escherichia coli, Pseudomonas chlororaphis subsp. aureofaciens, Serratia marcescens
-
Manually annotated by BRENDA team
Ipata, P.L.; Cercignani, G.
Cytosine and cytidine deaminase from yeast
Methods Enzymol.
51
394-401
1978
Saccharomyces cerevisiae
Manually annotated by BRENDA team
West, T.P.; Shanley, M.S.; O'Donovan, G.A.
Purification and some properties of cytosine deaminase from Salmonella typhimurium
Biochim. Biophys. Acta
791
251-258
1982
Saccharomyces cerevisiae, Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium HD11-AE2
Manually annotated by BRENDA team
West, T.P.
Effect of pyrophosphate and orotidine monophosphate on cytosine deaminase regulatory properties
Experientia
41
1563-1564
1988
Saccharomyces cerevisiae, Pseudomonas chlororaphis subsp. aureofaciens, Salmonella enterica subsp. enterica serovar Typhimurium, Serratia marcescens, Salmonella enterica subsp. enterica serovar Typhimurium HD11-AE2
Manually annotated by BRENDA team
Kornblatt, M.J.; Tee, O.S.
Inhibition of yeast cytosine deaminase by 5-bromo-2-pyrimidinone and its covalent hydrate
Eur. J. Biochem.
756
297-300
1986
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Katsuragi, T.; Sakai, T.; Matsumoto, K.; Tonomura, K.
Cytosine deaminase from Escherichia coli-production, purification and some characteristics
Agric. Biol. Chem.
50
1721-1730
1986
Saccharomyces cerevisiae, Escherichia coli, Pseudomonas chlororaphis subsp. aureofaciens, Salmonella enterica subsp. enterica serovar Typhimurium, Serratia marcescens
-
Manually annotated by BRENDA team
Yu, T.S.; Kim, J.K.; Kasuragi, T.; Sakai, T.; Tonomura, K.
Purification and properties of cytosine deaminase from Aspergillus fumigatus
J. Ferment. Bioeng.
72
266-269
1991
Arthrobacter sp., Aspergillus fumigatus, Saccharomyces cerevisiae, Salmonella enterica subsp. enterica serovar Typhimurium, Serratia marcescens, Arthrobacter sp. JH-13, Aspergillus fumigatus IFO5840
-
Manually annotated by BRENDA team
Erbs, P.; Exinger, F.; Jund, R.
Characterization of the Saccharomyces cerevisiae FCY1 gene encoding cytosine deaminase and its homologue FCA1 of Candida albicans
Curr. Genet.
31
1-6
1997
Aspergillus fumigatus, Saccharomyces cerevisiae, Candida albicans, Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium, Aspergillus fumigatus IFO5840
Manually annotated by BRENDA team
Yu, T.S.; Kim, J.; Kim, H.S.
Chemical modification of cytosine deaminase from Aspergillus fumigatus
J. Microbiol.
36
39-42
1998
Aspergillus fumigatus, Saccharomyces cerevisiae, Chromobacterium violaceum, Escherichia coli, Pseudomonas chlororaphis subsp. aureofaciens, Salmonella enterica subsp. enterica serovar Typhimurium, Serratia marcescens, Chromobacterium violaceum YK 391
-
Manually annotated by BRENDA team
Kim, T.H.; Yu, T.S.
Chemical modification of extracellular cytosine deaminase from Chromobacterium violaceum YK 391
J. Microbiol. Biotechnol.
8
581-587
1998
Arthrobacter sp., Aspergillus fumigatus, Paenibacillus polymyxa, Saccharomyces cerevisiae, Chromobacterium violaceum, Escherichia coli, Pseudomonas chlororaphis subsp. aureofaciens, Salmonella enterica subsp. enterica serovar Typhimurium, Serratia marcescens, Chromobacterium violaceum YK 391
-
Manually annotated by BRENDA team
Hsu, Y.H.; Hu, C.Y.; Lin, J.J.; Liaw, S.H.
Crystallization and preliminary crystallographic analysis of yeast cytosine deaminase
Acta Crystallogr. Sect. D
59
950-952
2003
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Ko, T.P.; Lin, J.J.; Hu, C.Y.; Hsu, Y.H.; Wang, A.H.; Liaw, S.H.
Crystal structure of yeast cytosine deaminase. Insights into enzyme mechanism and evolution
J. Biol. Chem.
278
19111-19117
2003
Saccharomyces cerevisiae (Q12178), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Ireton, G.C.; Stoddard, B.L.
Microseed matrix screening to improve crystals of yeast cytosine deaminase. [Erratum to document cited in CA141:019564]
Acta Crystallogr. Sect. D
D60
801
2004
Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Yao, L.; Li, Y.; Wu, Y.; Liu, A.; Yan, H.
Product release is rate-limiting in the activation of the prodrug 5-fluorocytosine by yeast cytosine deaminase
Biochemistry
44
5940-5947
2005
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Yao, L.; Sklenak, S.; Yan, H.; Cukier, R.I.
A molecular dynamics exploration of the catalytic mechanism of yeast cytosine deaminase
J. Phys. Chem. B
109
7500-7510
2005
Saccharomyces cerevisiae
Manually annotated by BRENDA team
O'Brien, T.A.; Tuong, D.T.; Basso, L.M.; McIvor, R.S.; Orchard, P.J.
Coexpression of the uracil phosphoribosyltransferase gene with a chimeric human nerve growth factor receptor/cytosine deaminase fusion gene, using a single retroviral vector, augments cytotoxicity of transduced human T cells exposed to 5-fluorocytosine
Hum. Gene Ther.
17
518-530
2006
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Xing, L.; Deng, X.; Kotedia, K.; Ackerstaff, E.; Ponomarev, V.; Clifton Ling, C.; Koutcher, J.A.; Li, G.C.
Non-invasive molecular and functional imaging of cytosine deaminase and uracil phosphoribosyltransferase fused with red fluorescence protein
Acta Oncol.
47
1211-1220
2008
Saccharomyces cerevisiae (Q12178)
Manually annotated by BRENDA team
Yao, L.; Yan, H.; Cukier, R.I.
A molecular dynamics study of the ligand release path in yeast cytosine deaminase
Biophys. J.
92
2301-2310
2007
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Ou-Yang, F.; Lan, K.L.; Chen, C.T.; Liu, J.C.; Weng, C.L.; Chou, C.K.; Xie, X.; Hung, J.Y.; Wei, Y.; Hortobagyi, G.N.; Hung, M.C.
Endostatin-cytosine deaminase fusion protein suppresses tumor growth by targeting neovascular endothelial cells
Cancer Res.
66
378-384
2006
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Lee, K.C.; Hamstra, D.A.; Bullarayasamudram, S.; Bhojani, M.S.; Moffat, B.A.; Dornfeld, K.J.; Ross, B.D.; Rehemtulla, A.
Fusion of the HSV-1 tegument protein vp22 to cytosine deaminase confers enhanced bystander effect and increased therapeutic benefit
Gene Ther.
13
127-137
2006
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Zamboni, S.; Mallano, A.; Flego, M.; Ascione, A.; Dupuis, M.L.; Gellini, M.; Barca, S.; Cianfriglia, M.
Genetic construction, expression, and characterization of a single chain anti-CEA antibody fused to cytosine deaminase from yeast
Int. J. Oncol.
32
1245-1251
2008
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Chen, J.K.; Hu, L.J.; Wang, D.; Lamborn, K.R.; Deen, D.F.
Cytosine deaminase/5-fluorocytosine exposure induces bystander and radiosensitization effects in hypoxic glioblastoma cells in vitro
Int. J. Radiat. Oncol. Biol. Phys.
67
1538-1547
2007
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Matsubara, T.; Dupuis, M.; Aida, M.
An insight into the environmental effects of the pocket of the active site of the enzyme. Ab initio ONIOM-molecular dynamics (MD) study on cytosine deaminase
J. Comput. Chem.
29
458-465
2008
Saccharomyces cerevisiae (Q12178)
Manually annotated by BRENDA team
Stolworthy, T.S.; Korkegian, A.M.; Willmon, C.L.; Ardiani, A.; Cundiff, J.; Stoddard, B.L.; Black, M.E.
Yeast cytosine deaminase mutants with increased thermostability impart sensitivity to 5-fluorocytosine
J. Mol. Biol.
377
854-869
2008
Saccharomyces cerevisiae (Q12178), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Yao, L.; Yan, H.; Cukier, R.I.
A combined ONIOM quantum chemical-molecular dynamics study of zinc-uracil bond breaking in yeast cytosine deaminase
J. Phys. Chem. B
110
26320-26326
2006
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Xu, Q.; Guo, H.; Gorin, A.; Guo, H.
Stabilization of a transition-state analogue at the active site of yeast cytosine deaminase: importance of proton transfers
J. Phys. Chem. B
111
6501-6506
2007
Saccharomyces cerevisiae (Q12178), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Maier, A.G.; Braks, J.A.; Waters, A.P.; Cowman, A.F.
Negative selection using yeast cytosine deaminase/uracil phosphoribosyl transferase in Plasmodium falciparum for targeted gene deletion by double crossover recombination
Mol. Biochem. Parasitol.
150
118-121
2006
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Fogar, P.; Navaglia, F.; Basso, D.; Greco, E.; Zambon, C.F.; Fadi, E.; Falda, A.; Stranges, A.; Vannozzi, F.; Danesi, R.; Pedrazzoli, S.; Plebani, M.
Suicide gene therapy with the yeast fusion gene cytosine deaminase/uracil phosphoribosyltransferase is not enough for pancreatic cancer
Pancreas
35
224-231
2007
Saccharomyces cerevisiae (Q12178), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Mallano, A.; Zamboni, S.; Carpinelli, G.; Santoro, F.; Flego, M.; Ascione, A.; Gellini, M.; Tombesi, M.; Podo, F.; Cianfriglia, M.
Generation and characterization of a human single-chain fragment variable (scFv) antibody against cytosine deaminase from yeast
BMC Biotechnol.
8
68
2008
Saccharomyces cerevisiae (Q12178), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Kucerova, L.; Matuskova, M.; Pastorakova, A.; Tyciakova, S.; Jakubikova, J.; Bohovic, R.; Altanerova, V.; Altaner, C.
Cytosine deaminase expressing human mesenchymal stem cells mediated tumour regression in melanoma bearing mice
J. Gene Med.
10
1071-1082
2008
Saccharomyces cerevisiae (Q12178), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Park, J.I.; Cao, L.; Platt, V.M.; Huang, Z.; Stull, R.A.; Dy, E.E.; Sperinde, J.J.; Yokoyama, J.S.; Szoka, F.C.
Antitumor therapy mediated by 5-fluorocytosine and a recombinant fusion protein containing TSG-6 hyaluronan binding domain and yeast cytosine deaminase
Mol. Pharm.
6
801-812
2009
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Wang, J.; Sklenak, S.; Liu, A.; Felczak, K.; Wu, Y.; Li, Y.; Yan, H.
Role of glutamate 64 in the activation of the prodrug 5-fluorocytosine by yeast cytosine deaminase
Biochemistry
51
475-486
2012
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Kucerova, L.; Matuskova, M.; Hlubinova, K.; Bohovic, R.; Feketeova, L.; Janega, P.; Babal, P.; Poturnajova, M.
Bystander cytotoxicity in human medullary thyroid carcinoma cells mediated by fusion yeast cytosine deaminase and 5-fluorocytosine
Cancer Lett.
311
101-112
2011
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Zhao, Y.; She, N.; Zhang, X.; Wang, C.; Mo, Y.
Product release mechanism and the complete enzyme catalysis cycle in yeast cytosine deaminase (yCD) A computational study
Biochim. Biophys. Acta
1865
1020-1029
2017
Saccharomyces cerevisiae (Q12178), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 (Q12178)
Manually annotated by BRENDA team
Blacklock, K.M.; Yachnin, B.J.; Woolley, G.A.; Khare, S.D.
Computational design of a photocontrolled cytosine deaminase
J. Am. Chem. Soc.
140
14-17
2018
Saccharomyces cerevisiae (Q12178), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 (Q12178)
Manually annotated by BRENDA team
Leonhardt, N.; Divol, F.; Chiarenza, S.; Deschamps, S.; Renaud, J.; Giacalone, C.; Laurent, N.; Berthome, R.; Peret, B.
Tissue-specific inactivation by cytosine deaminase/uracil phosphoribosyl transferase as a tool to study plant biology
Plant J.
101
731-741
2019
Saccharomyces cerevisiae (Q12178), Saccharomyces cerevisiae ATCC 204508 (Q12178)
Manually annotated by BRENDA team