Literature summary for 3.5.4.1 extracted from

Blacklock, K.M.; Yachnin, B.J.; Woolley, G.A.; Khare, S.D.
Computational design of a photocontrolled cytosine deaminase (2018), J. Am. Chem. Soc., 140, 14-17 .

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Application

Application	Comment	Organism
molecular biology	structure-based, computation-guided predictive method for reversibly controlling enzyme activity using covalently attached photo-responsive azobenzene groups. Application on yeast cytosine deaminase obtains an about 3fold change in enzyme activity by the photo-controlled modulation of the enzyme's active site lid structure, while fully maintaining thermostability. Multiple cycles of switching, controllable in real time, are possible	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	Q12178	-	-
Saccharomyces cerevisiae ATCC 204508	Q12178	-	-

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Release 2023.1 (January 2023)