Application | Comment | Organism |
---|---|---|
medicine | - |
Escherichia coli |
medicine | facilitate pharmacological advance, possible application is transfer of FCY1 and FCA1 to mammalian cells naturally lacking enzyme activity, these genes should confer lethal sensitivity to 5-fluorocytosine | Saccharomyces cerevisiae |
medicine | facilitate pharmacological advance, possible application is transfer of FCY1 and FCA1 to mammalian cells naturally lacking enzyme activity, these genes should confer lethal sensitivity to 5-fluorocytosine | Candida albicans |
Cloned (Comment) | Organism |
---|---|
codBA operon encoding cytosine permease and cytosine deaminase cloned | Escherichia coli |
FCA1 gene cloned from a genomic Candida albicans gene bank, constructed in the low-copy vector pMK122 | Candida albicans |
FCY1 gene cloned and characterized | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytosine + H2O | Salmonella enterica subsp. enterica serovar Typhimurium | - |
uracil + NH3 | - |
? | |
cytosine + H2O | Escherichia coli | - |
uracil + NH3 | - |
? | |
cytosine + H2O | Saccharomyces cerevisiae | - |
uracil + NH3 | - |
? | |
cytosine + H2O | Candida albicans | - |
uracil + NH3 | - |
? | |
cytosine + H2O | Aspergillus fumigatus | - |
uracil + NH3 | - |
? | |
cytosine + H2O | Aspergillus fumigatus IFO5840 | - |
uracil + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus fumigatus | - |
IFO5840 | - |
Aspergillus fumigatus IFO5840 | - |
IFO5840 | - |
Candida albicans | - |
- |
- |
Escherichia coli | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytosine + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | uracil + NH3 | - |
? | |
cytosine + H2O | - |
Escherichia coli | uracil + NH3 | - |
? | |
cytosine + H2O | - |
Saccharomyces cerevisiae | uracil + NH3 | - |
? | |
cytosine + H2O | - |
Candida albicans | uracil + NH3 | - |
? | |
cytosine + H2O | - |
Aspergillus fumigatus | uracil + NH3 | - |
? | |
cytosine + H2O | - |
Aspergillus fumigatus IFO5840 | uracil + NH3 | - |
? |