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8-oxoguanine DNA glycosylase
Afogg enzyme
bifunctional enzyme with both DNA glycosylase and apurinic/apyrimidinic lyase activities
8-oxoG DNA glycosylase
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8-oxoG DNA glycosylase
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8-oxoguanine DNA glycosylase
bifunctional enzyme that catalyzes the excision of 8-oxoguanine by cleaving the N-glycosylic bond between the base and the deoxyribose moiety (glycosylase activity) and subsequently cleave the DNA backbone (lyase activity, EC 4.2.99.18)
8-oxoguanine DNA glycosylase
bifunctional enzyme that catalyzes the excision of 8-oxoguanine by cleaving the N-glycosylic bond between the base and the deoxyribose moiety (glycosylase activity) and subsequently cleave the DNA backbone (lyase activity, EC 4.2.99.18)
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archaeal GO glycosylase
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archaeal GO glycosylase
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GO-glycosylase
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MJ0724
locus name
MjaOgg2
bifunctional enzyme that catalyzes the excision of 8-oxoguanine by cleaving the N-glycosylic bond between the base and the deoxyribose moiety (glycosylase activity) and subsequently cleave the DNA backbone (lyase activity, EC 4.2.99.18)
MjaOgg2
bifunctional enzyme that catalyzes the excision of 8-oxoguanine by cleaving the N-glycosylic bond between the base and the deoxyribose moiety (glycosylase activity) and subsequently cleave the DNA backbone (lyase activity, EC 4.2.99.18)
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mjOgg
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Ogg2
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oxoG DNA glycosylase
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Pa-AGOG
bifunctional enzyme that catalyzes the excision of 8-oxoguanine by cleaving the N-glycosylic bond between the base and the deoxyribose moiety (glycosylase activity) and subsequently cleave the DNA backbone (lyase activity, EC 4.2.99.18)
Pa-AGOG
bifunctional enzyme that catalyzes the excision of 8-oxoguanine by cleaving the N-glycosylic bond between the base and the deoxyribose moiety (glycosylase activity) and subsequently cleave the DNA backbone (lyase activity, EC 4.2.99.18)
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Pa-AGOG DNA glycosylase
bifunctional enzyme that catalyzes the excision of 8-oxoguanine by cleaving the N-glycosylic bond between the base and the deoxyribose moiety (glycosylase activity) and subsequently cleave the DNA backbone (lyase activity)
Pa-AGOG DNA glycosylase
bifunctional enzyme that catalyzes the excision of 8-oxoguanine by cleaving the N-glycosylic bond between the base and the deoxyribose moiety (glycosylase activity) and subsequently cleave the DNA backbone (lyase activity, EC 4.2.99.18)
Pa-AGOG DNA glycosylase
bifunctional enzyme that catalyzes the excision of 8-oxoguanine by cleaving the N-glycosylic bond between the base and the deoxyribose moiety (glycosylase activity) and subsequently cleave the DNA backbone (lyase activity)
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Pa-AGOG DNA glycosylase
bifunctional enzyme that catalyzes the excision of 8-oxoguanine by cleaving the N-glycosylic bond between the base and the deoxyribose moiety (glycosylase activity) and subsequently cleave the DNA backbone (lyase activity, EC 4.2.99.18)
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PAE2237
locus name
SSO0904
locus name
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DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
additional information
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enzyme displays DNA glycosylase, and apurinic/apyrimidinic lyase activities on 7,8-dihydro-8-oxoguanine/N (where N is A, T, G, or C) mismatch. The enzyme cannot eliminate U from U/G or T from T/G
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DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
the enzyme excises an oxidatively-damaged form of guanine. Bifunctional enzyme with both DNA glycosylase and apurinic/apyrimidinic lyase activities
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DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
bifunctional enzyme with both DNA glycosylase and apurinic/apyrimidinic lyase activities. The specificity of DNA glycosylase activity of is compared using 39-mer DNA duplexes containing an 8-oxoG residue opposite each of the four natural DNA bases (A, T, G and C). The enzyme efficiently cleaves oligomers containing 8-oxoG:C and 8-oxoG:G base pairs, less effective on oligomers containing 8-oxoG:T and 8-oxoG:A mispairs. The enzyme catalyzes a beta-elimination reaction at the apurinic site produced by excision of the 8-oxoguanine and thus generates a 5'-phosphate terminus and a 3'-alpha,beta-unsaturated aldehyde sugar terminus at the incision site
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DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
base excision repair pathway
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DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
DNA substrate used for glycosylase assay: 5'-TGTCAATAGCAAG-X-GGAGAAGTCAATCGTAGTCT-3' for the damage-containing strand, where X is either 8-oxoguanine or uracil, and 5'-AGACTCACGATTGACTTCTCC-Y-CTTGCTATTGACA-3' for the complementary strand, where Y is either one of the four bases. The enzyme displays little preference for the base opposite 8-oxoguanine
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DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
the enzyme has little specificity for the base opposite 8-oxoguanine. The enzyme has both DNA glycosylase and DNA lyase (beta-elimination) activity, and the combined glycosylase/lyase activity occurs at a rate comparable with the glycosylase activity alone
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DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
the enzyme has little specificity for the base opposite 8-oxoguanine. The enzyme has both DNA glycosylase and DNA lyase (beta-elimination) activity, and the combined glycosylase/lyase activity occurs at a rate comparable with the glycosylase activity alone
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DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
base excision repair pathway
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?
DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
DNA substrate used for glycosylase assay: 5'-TGTCAATAGCAAG-X-GGAGAAGTCAATCGTAGTCT-3' for the damage-containing strand, where X is either 8-oxoguanine or uracil, and 5'-AGACTCACGATTGACTTCTCC-Y-CTTGCTATTGACA-3' for the complementary strand, where Y is either one of the four bases. The enzyme displays little preference for the base opposite 8-oxoguanine
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DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
bifunctional enzyme that catalyzes the excision of 8-oxoguanine by cleaving the N-glycosylic bond between the base and the deoxyribose moiety (glycosylase activity) and subsequently cleave the DNA backbone (lyase activity, EC 4.2.99.18)
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DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
the enzyme that is part of the base excision repair (BER) pathway. It protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine, from single- and double-stranded DNA substrates
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DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
at 37°C and 47°C, the enzyme shows a slightly higher rate for the removal of 8-oxoguanine fom the double-stranded DNA substrate as compared to the single stranded substrate. At 5°C, the activity on 8-oxoguanine containing duplex DNA is much more strongly reduced than on the single-stranded substrate. For the double-stranded DNA substrates, the observed rate constants for both base excision and base excision/beta-lyase activity show a small but significant preference for 8-oxoguanine/G as against 8-oxoguanine/C and 8-oxoguanine/A
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DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
at 60°C, the enzyme is able to process more than 90% of the 8-oxoguanine/guanine and 8-oxoguanine/cytosine substrates in 15 min, at a substrate to enzyme ratio of 10:1
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DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
bifunctional enzyme that catalyzes the excision of 8-oxoguanine by cleaving the N-glycosylic bond between the base and the deoxyribose moiety (glycosylase activity) and subsequently cleave the DNA backbone (lyase activity, EC 4.2.99.18)
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-
?
DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
at 37°C and 47°C, the enzyme shows a slightly higher rate for the removal of 8-oxoguanine fom the double-stranded DNA substrate as compared to the single stranded substrate. At 5°C, the activity on 8-oxoguanine containing duplex DNA is much more strongly reduced than on the single-stranded substrate. For the double-stranded DNA substrates, the observed rate constants for both base excision and base excision/beta-lyase activity show a small but significant preference for 8-oxoguanine/G as against 8-oxoguanine/C and 8-oxoguanine/A
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DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
the enzyme that is part of the base excision repair (BER) pathway. It protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine, from single- and double-stranded DNA substrates
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?
DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
at 60°C, the enzyme is able to process more than 90% of the 8-oxoguanine/guanine and 8-oxoguanine/cytosine substrates in 15 min, at a substrate to enzyme ratio of 10:1
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DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
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?
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DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
the enzyme excises an oxidatively-damaged form of guanine. Bifunctional enzyme with both DNA glycosylase and apurinic/apyrimidinic lyase activities
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?
DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
base excision repair pathway
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?
DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
base excision repair pathway
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-
?
DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
bifunctional enzyme that catalyzes the excision of 8-oxoguanine by cleaving the N-glycosylic bond between the base and the deoxyribose moiety (glycosylase activity) and subsequently cleave the DNA backbone (lyase activity, EC 4.2.99.18)
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-
?
DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
the enzyme that is part of the base excision repair (BER) pathway. It protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine, from single- and double-stranded DNA substrates
-
-
?
DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
bifunctional enzyme that catalyzes the excision of 8-oxoguanine by cleaving the N-glycosylic bond between the base and the deoxyribose moiety (glycosylase activity) and subsequently cleave the DNA backbone (lyase activity, EC 4.2.99.18)
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-
?
DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
the enzyme that is part of the base excision repair (BER) pathway. It protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine, from single- and double-stranded DNA substrates
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-
?
DNA containing 8-oxoguanine + H2O
DNA with an abasic site + 8-oxoguanine
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?
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Lingaraju, G.M.; Prota, A.E.; Winkler, F.K.
Mutational studies of Pa-AGOG DNA glycosylase from the hyperthermophilic crenarchaeon Pyrobaculum aerophilum
DNA Repair
8
857-864
2009
Pyrobaculum aerophilum (Q8ZVK6), Pyrobaculum aerophilum DSM 7523 (Q8ZVK6)
brenda
Gogos, A.; Clarke, N.D.
Characterization of an 8-oxoguanine DNA glycosylase from Methanococcus jannaschii
J. Biol. Chem.
274
30447-30450
1999
Methanocaldococcus jannaschii (Q58134), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661 (Q58134)
brenda
Faucher, F.; Wallace, S.S.; Doubli, S.
The C-terminal lysine of Ogg2 DNA glycosylases is a major molecular determinant for guanine/8-oxoguanine distinction
J. Mol. Biol.
397
46-56
2010
Methanocaldococcus jannaschii (Q58134), Methanocaldococcus jannaschii DSM 2661 (Q58134)
brenda
Chung, J.H.; Suh, M.J.; Park, Y.I.; Tainer, J.A.; Han, Y.S.
Repair activities of 8-oxoguanine DNA glycosylase from Archaeoglobus fulgidus, a hyperthermophilic archaeon
Mutat. Res.
486
99-111
2001
Archaeoglobus fulgidus (O29876), Archaeoglobus fulgidus
brenda
Sartori, A.A.; Lingaraju, G.M.; Hunziker, P.; Winkler, F.K.; Jiricny, J.
Pa-AGOG, the founding member of a new family of archaeal 8-oxoguanine DNA-glycosylases
Nucleic Acids Res.
32
6531-6539
2004
Pyrobaculum aerophilum (Q8ZVK6), Pyrobaculum aerophilum DSM 7523 (Q8ZVK6)
brenda
Lingaraju, G.M.; Sartori, A.A.; Kostrewa, D.; Prota, A.E.; Jiricny, J.; Winkler, F.K.
A DNA glycosylase from Pyrobaculum aerophilum with an 8-oxoguanine binding mode and a noncanonical helix-hairpin-helix structure
Structure
13
87-98
2005
Pyrobaculum aerophilum (Q8ZVK6), Pyrobaculum aerophilum DSM 7523 (Q8ZVK6)
brenda
Faucher, F.; Duclos, S.; Bandaru, V.; Wallace, S.S.; Doublie, S.
Crystal structures of two archaeal 8-oxoguanine DNA glycosylases provide structural insight into guanine/8-oxoguanine distinction
Structure
17
703-712
2009
Methanocaldococcus jannaschii (Q58134), Saccharolobus solfataricus (Q97ZK2), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q97ZK2), Methanocaldococcus jannaschii DSM 2661 (Q58134)
brenda
Minoshima, H.; Ikeda, Y.; Fujii, M.; Satoh, M.; Ishikawa, T.; Itoh, Y.; Kawashima-Ohya, Y.; Tomobe, K.; Omata, Y.; Kawashima, T.
Specificity of Fur binding to the oxidative stress response gene promoter in the facultative anaerobic archaeon Thermoplasma volcanium
Biol. Pharm. Bull.
37
481-485
2014
Thermoplasma volcanium
brenda
Fujii, M.; Hata, C.; Ukita, M.; Fukushima, C.; Matsuura, C.; Kawashima-Ohya, Y.; Tomobe, K.; Kawashima, T.
Characterization of a thermostable 8-oxoguanine DNA glycosylase specific for GO/N mismatches from the thermoacidophilic archaeon Thermoplasma volcanium
Archaea
2016
8734894
2016
Thermoplasma volcanium
brenda