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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.B5physiological function base excision repair pathway -, 726497
Display the word mapDisplay the reaction diagram Show all sequences 3.2.2.B5physiological function the enzyme that is part of the base excision repair (BER) pathway. It protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine, from single- and double-stranded DNA substrates. Bifunctional enzyme that catalyzes the excision of 8-oxoguanine by cleaving the N-glycosylic bond between the base and the deoxyribose moiety (glycosylase activity) and subsequently cleave the DNA backbone (lyase activity, EC 4.2.99.18) -, 726058
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