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Ligand 7,8-dihydro-8-oxoguanine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.5.4.32

8-oxoguanine + H2O = 8-oxoxanthine + NH3

715275

-

3.5.4.32

8-oxoguanine + H2O = urate + NH3

715275

-

3.5.4.32

2 entries

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

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Show Natural Product (5 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.2.23

DNA containing 8-hydroxyguanine residues + H2O = 8-hydroxyguanine + DNA

0

-

3.2.2.23

8-oxo-7,8-dihydroguanine:Cyt oligodeoxynucleotide + H2O = 8-oxo-7,8-dihydroguanine + Cyt oligodeoxynucleotide

0

-

3.2.2.23

8-oxo-7,8-dihydroguanine:Cyt-DNA + H2O = 8-oxo-7,8-dihydroguanine + Cyt-DNA

0

-

3.2.2.23

DNA containing 8-oxoguanine residues + H2O = DNA + 8-oxoguanine

0

-

3.2.2.23

4 entries

3.2.2.B5

DNA containing 8-oxoguanine + H2O = DNA with an abasic site + 8-oxoguanine

0

-

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.5.4.32

8-oxoguanine + H2O = 8-oxoxanthine + NH3

715275

-

3.5.4.32

8-oxoguanine + H2O = urate + NH3

754506, 715275

-

3.5.4.32

2 entries

Product in Enzyme-catalyzed Reactions (26 results)

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Show Product (26 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.17.3.2

guanine + H2O + O2 = 2-amino-7,9-dihydro-1H-purine-6,8-dione + H2O2

0, 644623

-

3.2.2.23

DNA containing 7,8-dihydro-8-oxoguanine residues + H2O = DNA + 7,8-dihydro-8-oxoguanine

0

-

3.2.2.23

DNA containing 8-hydroxyadenine + H2O = DNA + 8-hydroxyguanine

0

-

3.2.2.23

DNA containing 8-hydroxyguanine residues + H2O = 8-hydroxyguanine + DNA

0, 646953

-

3.2.2.23

DNA containing 8-oxo-7,8-dihydroguanine residues + H2O = DNA + 8-hydroxyguanine

0

-

3.2.2.23

8-oxo-7,8-dihydroguanine:Cyt oligodeoxynucleotide + H2O = 8-oxo-7,8-dihydroguanine + Cyt oligodeoxynucleotide

0

-

3.2.2.23

8-oxo-7,8-dihydroguanine:Cyt-DNA + H2O = 8-oxo-7,8-dihydroguanine + Cyt-DNA

0

-

3.2.2.23

DNA containing 8-oxo-7,8-dihydroguanine residues + H2O = DNA + 8-oxo-7,8-dihydroguanine

0

-

3.2.2.23

13mer oligonucleotide duplex containing 8-oxoguanine + H2O = 8-oxoguanine + oligonucleotide

0

-

3.2.2.23

23mer oligonucleotide duplex containing 8-oxoguanine + H2O = 8-oxoguanine + oligonucleotide

0

-

3.2.2.23

53mer containing 8-oxoguanine + H2O = 53mer with an abasic site + 8-oxoguanine

0

-

3.2.2.23

60mer containing 8-oxoguanine + H2O = 60mer with an abasic site + 8-oxoguanine

0

-

3.2.2.23

DNA containing 8-oxo-guanine residues + H2O = DNA + 8-oxoguanine

0

-

3.2.2.23

DNA containing 8-oxo-guanine residues mispaired to adenine + H2O = DNA + 8-oxoguanine

0

-

3.2.2.23

DNA containing 8-oxo-guanine residues mispaired to guanine + H2O = DNA + 8-oxoguanine

0

-

3.2.2.23

DNA containing 8-oxo-guanine residues mispaired to thymine + H2O = DNA + 8-oxoguanine

0

-

3.2.2.23

DNA containing 8-oxoguanine opposite A + H2O = 8-oxoguanine + DNA

0

-

3.2.2.23

DNA containing 8-oxoguanine opposite C + H2O = 8-oxoguanine + DNA

0

-

3.2.2.23

DNA containing 8-oxoguanine opposite G + H2O = 8-oxoguanine + DNA

0

-

3.2.2.23

DNA containing 8-oxoguanine opposite T + H2O = 8-oxoguanine + DNA

0

-

3.2.2.23

DNA containing 8-oxoguanine residues + H2O = 8-oxoguanine + DNA

0

-

3.2.2.23

DNA containing 8-oxoguanine residues + H2O = DNA + 8-oxoguanine

0

-

3.2.2.23

DNA containing dihydrouracil + H2O = 8-oxoguanine + DNA

0

-

3.2.2.27

8-oxoguanine-mismatched double-stranded DNA + H2O = 8-oxoguanine + double-stranded DNA with abasic site

0

-

3.2.2.27

8-oxoguanine-mismatched single-stranded DNA + H2O = 8-oxoguanine + single-stranded DNA with abasic site

0

-

3.2.2.23

22 entries

3.2.2.27

2 entries

3.2.2.B5

DNA containing 8-oxoguanine + H2O = DNA with an abasic site + 8-oxoguanine

0

-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.5.1.15

-

759069

-

Enzyme Kinetic Parameters

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

644623

-

Purification and properties of xanthine oxidase from Enterobacter cloacae

1981

Machida, Y.; Nakanishi, T.

Agric. Biol. Chem.

45

425-432

646953

10671534

Distinct repair activities of human 7,8-dihydro-8-oxoguanine DNA glycosylase and formamidopyrimidine DNA glycosylase for formamidopyrimidine and 7,8-dihydro-8-oxoguanine

2000

Asagoshi, K.; Yamada, T.; Terato, H.; Ohyama, Y.; Monden, Y.; Arai, T.; Nishimura, S.; Aburatani, H.; Lindahl, T.; Ide, H.

J. Biol. Chem.

275

4956-4964

715275

20088583

The hunt for 8-oxoguanine deaminase

2010

Hall, R.S.; Fedorov, A.A.; Marti-Arbona, R.; Fedorov, E.V.; Kolb, P.; Sauder, J.M.; Burley, S.K.; Shoichet, B.K.; Almo, S.C.; Raushel, F.M.

J. Am. Chem. Soc.

132

1762-1763

754506

-

Mechanisms for the deamination reaction of 8-oxoguanine catalyzed by 8-oxoguanine deaminase a combined QM/MM molecular dynamics study

2016

Zhang, X.; Zhao, Y.; Duan, X.; Zhang, H.; Cao, Z.; Mo, Y.

J. Theor. Comput. Chem.

15

1650066

759069

29171692

8-Mercaptoguanine derivatives as inhibitors of dihydropteroate synthase

2018

Dennis, M.L.; Lee, M.D.; Harjani, J.R.; Ahmed, M.; DeBono, A.J.; Pitcher, N.P.; Wang, Z.C.; Chhabra, S.; Barlow, N.; Rahmani, R.; Cleary, B.; Dolezal, O.; Hattarki, M.; Aurelio, L.; Shonberg, J.; Graham, B.; Peat, T.S.; Baell, J.B.; Swarbrick, J.D.

Chemistry

24

1922-1930

Links to other databases for 7,8-dihydro-8-oxoguanine

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Show Links (1 entry)

ChEBI

PubChem