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cyclic ADP-ribose + H2O = ADP-D-ribose
(1b)
-
-
-
NAD+ + H2O = ADP-D-ribose + nicotinamide + H+
NAD+ = cyclic ADP-ribose + nicotinamide
(1a)
-
-
-
NAD+ + H2O = ADP-D-ribose + nicotinamide + H+

also catalyses transfer of ADP-ribose(P) residues
-
NAD+ + H2O = ADP-D-ribose + nicotinamide + H+
reaction mechanism, overview
NAD+ + H2O = ADP-D-ribose + nicotinamide + H+
(overall reaction)
-
-
-
NAD+ + H2O = ADP-D-ribose + nicotinamide + H+
structure-function analysis and reaction mechanism, overview. The nicotinamide-ribosyl bond of NAD+ is cleaved via a dissociative process with a late transition state, leading to a ribooxocarbenium ion reaction intermediate stabilized by the side-chain of invariant Glu218. This rate-determining step is followed by two nucleophilic reactions in competition: (i) an intermolecular pathway involving a rapid trapping from the b-face of this intermediate by a water molecule (NAD+ glycohydrolase activity) or by competing neutral nucleophiles such as pyridines (transglycosidation reactions) or alcohols (e.g., methanolysis), and (ii) an intramolecular reaction between N1 of the adenine ring and C19 (anomeric carbon) of the oxocarbenium ion leading to the formation of cyclic ADP-ribose (ADP-ribosyl cyclase activity). This latter reaction represents a kinetically minor step relative to solvolysis
NAD+ + H2O = ADP-D-ribose + nicotinamide + H+
substrate binding with a crucial role of Glu218, which orients the substrate for cleavage by interacting with the N-ribosyl 2'-OH group of NAD+, stepwise ordered uni-bi kinetic mechanism, overview. Residues Trp118, Glu138, Asp147, Trp181 stabilize the ribooxocarbenium ion-like transition state mostly by electrostatic interactions
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1,N6-etheno NAD+ + H2O
epsilon-ADP-ribose + nicotinamide + H+
-
-
-
-
?
3-acetylpyridine + adenosine diphosphoribose
3-acetylpyridine adenine dinucleotide + phosphate
-
transglycosylation activity, very poor hydrolytic activity with this substrate
-
-
?
3-acetylpyridine adenine dinucleotide + H2O
?
-
-
-
-
?
3-acetylpyridine hypoxanthine dinucleotide + H2O
?
-
low activity
-
-
?
3-pyridine adenine dinucleotide + H2O
?
-
-
-
-
?
3-pyridinealdehyde hypoxanthine dinucleotide + H2O
?
alpha-NAD+ + H2O
?
-
-
-
-
?
cyclic ADP-ribose + H2O
?
-
-
-
-
?
cyclic ADP-ribose + H2O
adenosine diphosphoribose + ?
-
i.e. ADPR activity
-
-
?
cyclic ADP-ribose + H2O
ADP-D-ribose
cyclic ADP-ribose + H2O
ADP-ribose
-
-
-
-
?
epsilon-NAD+ + H2O
?
-
-
-
-
?
epsilon-NADP+ + H2O
?
-
-
-
-
?
NAD+
cyclic ADP-ribose + nicotinamide
NAD+ + ?
cyclic ADP-ribose + ?
-
i.e. cADPR activity
-
-
?
NAD+ + H2O
ADP-D-ribose + nicotinamide
NAD+ + H2O
ADP-ribose + nicotinamide
-
-
-
-
?
NAD+ + H2O
cyclic ADP-ribose + nicotinamide + H+
-
the cyclization and hydrolysis of NAD(P)+ occur optimally at physiological pH
-
-
?
NADP+ + H2O
ADP-ribose-P + nicotinamide
-
80% activity compared to the activity with NAD+
-
-
?
NADP+ + H2O
nicotinamide + ADPribose-phosphate
NADP+ + nicotinic acid
nicotinic acid adenine dinucleotide phosphate
-
this reaction occurs only in acidic pH
-
-
?
NGD+ + H2O
cyclic GDP-ribose
-
-
-
-
?
NGD+ + H2O
GDP-ribose + nicotinamide
-
as effective as substrate as NAD+
-
-
?
nicotinamide 1,N6-ethenoadenine dinucleotide + H2O
?
-
i.e. epsilonNAD+, used for a fluorometric assay
-
-
?
nicotinamide guanine dinucleotide + H2O
?
-
-
-
-
?
nicotinamide-hypoxanthine dinucleotide + H2O
?
nicotinamide-hypoxanthine dinucleotide phosphate + H2O
?
-
-
-
-
?
additional information
?
-
3-pyridinealdehyde hypoxanthine dinucleotide + H2O

?
-
-
-
-
?
3-pyridinealdehyde hypoxanthine dinucleotide + H2O
?
-
60% activity compared to the activity with NAD+
-
-
?
beta-NAD+ + H2O

?
-
-
-
-
?
beta-NAD+ + H2O
?
-
beta-NAD+ and NADP+ are hydrolyzed at equal rates
-
-
?
cyclic ADP-ribose + H2O

ADP-D-ribose
-
-
-
?
cyclic ADP-ribose + H2O
ADP-D-ribose
-
-
-
?
cyclic ADP-ribose + H2O
ADP-D-ribose
-
-
-
-
?
cyclic ADP-ribose + H2O
ADP-D-ribose
-
-
-
?
NAD+

cyclic ADP-ribose + nicotinamide
-
-
-
?
NAD+
cyclic ADP-ribose + nicotinamide
-
-
-
?
NAD+
cyclic ADP-ribose + nicotinamide
-
-
-
?
NAD+
cyclic ADP-ribose + nicotinamide
-
-
-
-
?
NAD+
cyclic ADP-ribose + nicotinamide
-
-
-
-
?
NAD+
cyclic ADP-ribose + nicotinamide
-
-
-
-
?
NAD+
cyclic ADP-ribose + nicotinamide
-
-
-
?
NAD+ + H2O

ADP-D-ribose + nicotinamide
-
-
-
?
NAD+ + H2O
ADP-D-ribose + nicotinamide
bovine CD38/NAD+ glycohydrolase catalyzes the hydrolysis of NAD+ to nicotinamide and ADP-ribose and the formation of cyclic ADP-ribose via a stepwise reaction mechanism
-
-
?
NAD+ + H2O
ADP-D-ribose + nicotinamide
via a stepwise reaction mechanism
-
-
?
NAD+ + H2O
ADP-D-ribose + nicotinamide
overall reaction
-
-
?
NAD+ + H2O
ADP-D-ribose + nicotinamide
via a stepwise reaction mechanism
-
-
?
NAD+ + H2O
ADP-D-ribose + nicotinamide
overall reaction
-
-
?
NAD+ + H2O
ADP-D-ribose + nicotinamide
-
overall reaction
-
-
?
NAD+ + H2O
ADP-D-ribose + nicotinamide
-
-
-
-
?
NAD+ + H2O
ADP-D-ribose + nicotinamide
overall reaction
-
-
?
NADP+ + H2O

nicotinamide + ADPribose-phosphate
-
-
-
-
?
NADP+ + H2O
nicotinamide + ADPribose-phosphate
-
-
-
?
NADP+ + H2O
nicotinamide + ADPribose-phosphate
-
-
-
-
?
NADP+ + H2O
nicotinamide + ADPribose-phosphate
-
-
-
-
?
NADP+ + H2O
nicotinamide + ADPribose-phosphate
-
-
-
-
?
NADP+ + H2O
nicotinamide + ADPribose-phosphate
-
-
-
-
?
nicotinamide-hypoxanthine dinucleotide + H2O

?
-
-
-
-
?
nicotinamide-hypoxanthine dinucleotide + H2O
?
-
-
-
-
?
thio-NAD+ + H2O

?
-
-
-
-
?
thio-NAD+ + H2O
?
-
-
-
-
?
additional information

?
-
the enzyme catalyses the hydrolysis of NAD+ into nicotinamide and ADP-ribose and the formation of cyclic ADP-ribose (cADPR)
-
-
?
additional information
?
-
-
the enzyme catalyses the hydrolysis of NAD+ into nicotinamide and ADP-ribose and the formation of cyclic ADP-ribose (cADPR)
-
-
?
additional information
?
-
selectivity in favor of methanolysis by wild-type enzyme and mutant E138A. 1'-Azido ADP-ribose is the reaction product obtained in the presence of azide. the ADP-ribosyl cyclase activity of wild-type bCD38 isminimal
-
-
?
additional information
?
-
-
selectivity in favor of methanolysis by wild-type enzyme and mutant E138A. 1'-Azido ADP-ribose is the reaction product obtained in the presence of azide. the ADP-ribosyl cyclase activity of wild-type bCD38 isminimal
-
-
?
additional information
?
-
-
the formation of an enzyme-ADP-ribosyl intermediary complex is common to all reaction pathways
-
-
?
additional information
?
-
-
enzyme is involved in the regulation of intracellular concentration of adenosine diphosphoribose
-
-
?
additional information
?
-
-
enzyme is multicatalytic, it also catalyzes the synthesis of cyclic ADP-ribose from NAD+ and the hydrolysis to adenosine diphosphoribose
-
-
?
additional information
?
-
-
CD38 is a multifunctional enzyme catalyzing the conversion of NAD(P)+ to three metabolites (cyclic ADP-ribose, nicotinic acid adenine dinucleotide phosphate and ADP-ribose)
-
-
?
additional information
?
-
CD38 is a NAD+-dependent, multifunctional ectoenzyme that cannot only generate cyclic ADP-ribose from NAD+ but also hydrolyze cyclic ADP-ribose to ADP-ribose and transport cyclic ADP-ribose into cells
-
-
?
additional information
?
-
-
enzyme may be induced by presence of protein in the culture medium. Low concentrations of sucrose or glucose, 0.1%, casamino acids or some amino acids such as Met, Cys, Phe and Trp strongly repress enzyme synthesis
-
-
?
additional information
?
-
-
synthesis of nicotinate adenine dinucleotide phosphate by exchange of nicotinamide for nicotinic acid
-
-
?
additional information
?
-
frog CD38 enzyme shows NAD+ glycohydrolase, ADP-ribosyl cyclase, and cyclic ADP-ribosyl hydrolase activities
-
-
?
additional information
?
-
-
frog CD38 enzyme shows NAD+ glycohydrolase, ADP-ribosyl cyclase, and cyclic ADP-ribosyl hydrolase activities
-
-
?
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cyclic ADP-ribose + H2O
ADP-D-ribose
NAD+
cyclic ADP-ribose + nicotinamide
NAD+ + H2O
ADP-D-ribose + nicotinamide
additional information
?
-
cyclic ADP-ribose + H2O

ADP-D-ribose
-
-
-
?
cyclic ADP-ribose + H2O
ADP-D-ribose
-
-
-
?
cyclic ADP-ribose + H2O
ADP-D-ribose
-
-
-
-
?
cyclic ADP-ribose + H2O
ADP-D-ribose
-
-
-
?
NAD+

cyclic ADP-ribose + nicotinamide
-
-
-
?
NAD+
cyclic ADP-ribose + nicotinamide
-
-
-
?
NAD+
cyclic ADP-ribose + nicotinamide
-
-
-
-
?
NAD+
cyclic ADP-ribose + nicotinamide
-
-
-
?
NAD+ + H2O

ADP-D-ribose + nicotinamide
-
-
-
?
NAD+ + H2O
ADP-D-ribose + nicotinamide
bovine CD38/NAD+ glycohydrolase catalyzes the hydrolysis of NAD+ to nicotinamide and ADP-ribose and the formation of cyclic ADP-ribose via a stepwise reaction mechanism
-
-
?
NAD+ + H2O
ADP-D-ribose + nicotinamide
overall reaction
-
-
?
NAD+ + H2O
ADP-D-ribose + nicotinamide
via a stepwise reaction mechanism
-
-
?
NAD+ + H2O
ADP-D-ribose + nicotinamide
overall reaction
-
-
?
NAD+ + H2O
ADP-D-ribose + nicotinamide
-
overall reaction
-
-
?
NAD+ + H2O
ADP-D-ribose + nicotinamide
overall reaction
-
-
?
additional information

?
-
the enzyme catalyses the hydrolysis of NAD+ into nicotinamide and ADP-ribose and the formation of cyclic ADP-ribose (cADPR)
-
-
?
additional information
?
-
-
the enzyme catalyses the hydrolysis of NAD+ into nicotinamide and ADP-ribose and the formation of cyclic ADP-ribose (cADPR)
-
-
?
additional information
?
-
-
enzyme is involved in the regulation of intracellular concentration of adenosine diphosphoribose
-
-
?
additional information
?
-
CD38 is a NAD+-dependent, multifunctional ectoenzyme that cannot only generate cyclic ADP-ribose from NAD+ but also hydrolyze cyclic ADP-ribose to ADP-ribose and transport cyclic ADP-ribose into cells
-
-
?
additional information
?
-
-
enzyme may be induced by presence of protein in the culture medium. Low concentrations of sucrose or glucose, 0.1%, casamino acids or some amino acids such as Met, Cys, Phe and Trp strongly repress enzyme synthesis
-
-
?
additional information
?
-
frog CD38 enzyme shows NAD+ glycohydrolase, ADP-ribosyl cyclase, and cyclic ADP-ribosyl hydrolase activities
-
-
?
additional information
?
-
-
frog CD38 enzyme shows NAD+ glycohydrolase, ADP-ribosyl cyclase, and cyclic ADP-ribosyl hydrolase activities
-
-
?
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1-[2-azido-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]-3-carbamoylpyridinium
1-[5-O-[(benzyloxy)(hydroxy)phosphoryl]-2-deoxy-2-fluoro-L-erythro-pentofuranosyl]-3-carbamoylpyridinium
1-[5-O-[butoxy(hydroxy)phosphoryl]-2-deoxy-2-fluoro-D-threo-pentofuranosyl]-3-carbamoylpyridinium
2'-deoxy-2'-beta-D-fluoroarabinofuranoside NAD+
-
2'-deoxy-2'-beta-D-fluororibofuranoside NAD+
non-covalent complex of the inhibitor formed with enzyme mutant E218Q, PDB ID: 3ghh, and with wild-type enzyme, PDB ID: 3kou
3-carbamoyl-1-[2-chloro-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]pyridinium
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-D-threo-pentofuranosyl]pyridinium
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-thiophosphono-L-erythro-pentofuranosyl]pyridinium
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[(hexyloxy)(hydroxy)phosphoryl]-D-threo-pentofuranosyl]pyridinium
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[hydroxy(2-phenylethoxy)phosphoryl]-L-erythro-pentofuranosyl]pyridinium
3-carbamoyl-1-[2-deoxy-2-fluoro-D-threo-pentofuranosyl]pyridinium
3-carbamoyl-1-[2-deoxy-5-O-(diethoxyphosphoryl)-2-fluoro-D-threo-pentofuranosyl]pyridinium
3-carbamoyl-1-[2-deoxy-5-O-[(ethenyloxy)(propoxy)phosphoryl]-2-fluoro-D-threo-pentofuranosyl]pyridinium
3-carbamoyl-1-[3-deoxy-3-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium
5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromenium
-
-
Ag+
-
50% inhibition of NADase and 300% activation of adenosine diphosphate cyclase; at 2 mM 50% inhibition of NADase activity and 300% activation of cADPR activity
arabinosyl 2'-fluoro-2'-deoxy-NAD
-
suicide substrate that inhibits CD38 ectoenzyme activity
arabinosyl-2'-fluoro-2'-deoxynicotinamide mononucleotide
Cr3+
-
inhibition of NADase and adenosine diphosphate cyclase
HClO4
-
5%, 2°C, 10 min, 60% loss of the original activity
Isonicotinic acid hydrazide
-
nicotinamide
inhibition involves enzyme residue Trp181
Pb2+
-
complete inhibition at 2 mM; inhibition of NADase and adenosine diphosphate cyclase
Pyridine
non-competitive inhibition of mutant E218A by pyridine
Sn2+
-
complete inhibition at 2 mM; inhibition of NADase and adenosine diphosphate cyclase
Zn2+
-
inhibition of NADase and adenosine diphosphate cyclase
1-[2-azido-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]-3-carbamoylpyridinium

inhibition of the NADase activity
1-[2-azido-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]-3-carbamoylpyridinium
inhibition of the NADase activity
1-[2-azido-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]-3-carbamoylpyridinium
-
inhibition of the NADase activity
1-[5-O-[(benzyloxy)(hydroxy)phosphoryl]-2-deoxy-2-fluoro-L-erythro-pentofuranosyl]-3-carbamoylpyridinium

inhibition of the NADase activity
1-[5-O-[(benzyloxy)(hydroxy)phosphoryl]-2-deoxy-2-fluoro-L-erythro-pentofuranosyl]-3-carbamoylpyridinium
inhibition of the NADase activity
1-[5-O-[(benzyloxy)(hydroxy)phosphoryl]-2-deoxy-2-fluoro-L-erythro-pentofuranosyl]-3-carbamoylpyridinium
-
inhibition of the NADase activity
1-[5-O-[butoxy(hydroxy)phosphoryl]-2-deoxy-2-fluoro-D-threo-pentofuranosyl]-3-carbamoylpyridinium

inhibition of the NADase activity
1-[5-O-[butoxy(hydroxy)phosphoryl]-2-deoxy-2-fluoro-D-threo-pentofuranosyl]-3-carbamoylpyridinium
inhibition of the NADase activity
1-[5-O-[butoxy(hydroxy)phosphoryl]-2-deoxy-2-fluoro-D-threo-pentofuranosyl]-3-carbamoylpyridinium
-
inhibition of the NADase activity
3-carbamoyl-1-[2-chloro-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]pyridinium

inhibition of the NADase activity
3-carbamoyl-1-[2-chloro-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
3-carbamoyl-1-[2-chloro-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]pyridinium
-
inhibition of the NADase activity
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-D-threo-pentofuranosyl]pyridinium

inhibition of the NADase activity
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-D-threo-pentofuranosyl]pyridinium
-
inhibition of the NADase activity
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium

inhibition of the NADase activity
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium
-
inhibition of the NADase activity
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-thiophosphono-L-erythro-pentofuranosyl]pyridinium

inhibition of the NADase activity
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-thiophosphono-L-erythro-pentofuranosyl]pyridinium
inhibition of the NADase activity
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-thiophosphono-L-erythro-pentofuranosyl]pyridinium
-
inhibition of the NADase activity
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[(hexyloxy)(hydroxy)phosphoryl]-D-threo-pentofuranosyl]pyridinium

inhibition of the NADase activity
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[(hexyloxy)(hydroxy)phosphoryl]-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[(hexyloxy)(hydroxy)phosphoryl]-D-threo-pentofuranosyl]pyridinium
-
inhibition of the NADase activity
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[hydroxy(2-phenylethoxy)phosphoryl]-L-erythro-pentofuranosyl]pyridinium

inhibition of the NADase activity
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[hydroxy(2-phenylethoxy)phosphoryl]-L-erythro-pentofuranosyl]pyridinium
inhibition of the NADase activity
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[hydroxy(2-phenylethoxy)phosphoryl]-L-erythro-pentofuranosyl]pyridinium
-
inhibition of the NADase activity
3-carbamoyl-1-[2-deoxy-2-fluoro-D-threo-pentofuranosyl]pyridinium

inhibition of the NADase activity
3-carbamoyl-1-[2-deoxy-2-fluoro-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
3-carbamoyl-1-[2-deoxy-2-fluoro-D-threo-pentofuranosyl]pyridinium
-
inhibition of the NADase activity
3-carbamoyl-1-[2-deoxy-5-O-(diethoxyphosphoryl)-2-fluoro-D-threo-pentofuranosyl]pyridinium

inhibition of the NADase activity
3-carbamoyl-1-[2-deoxy-5-O-(diethoxyphosphoryl)-2-fluoro-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
3-carbamoyl-1-[2-deoxy-5-O-(diethoxyphosphoryl)-2-fluoro-D-threo-pentofuranosyl]pyridinium
-
inhibition of the NADase activity
3-carbamoyl-1-[2-deoxy-5-O-[(ethenyloxy)(propoxy)phosphoryl]-2-fluoro-D-threo-pentofuranosyl]pyridinium

inhibition of the NADase activity
3-carbamoyl-1-[2-deoxy-5-O-[(ethenyloxy)(propoxy)phosphoryl]-2-fluoro-D-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
3-carbamoyl-1-[2-deoxy-5-O-[(ethenyloxy)(propoxy)phosphoryl]-2-fluoro-D-threo-pentofuranosyl]pyridinium
-
inhibition of the NADase activity
3-carbamoyl-1-[3-deoxy-3-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium

inhibition of the NADase activity
3-carbamoyl-1-[3-deoxy-3-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium
inhibition of the NADase activity
3-carbamoyl-1-[3-deoxy-3-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium
-
inhibition of the NADase activity
arabinosyl-2'-fluoro-2'-deoxynicotinamide mononucleotide

inhibition of the NADase activity
arabinosyl-2'-fluoro-2'-deoxynicotinamide mononucleotide
inhibition of the NADase activity
arabinosyl-2'-fluoro-2'-deoxynicotinamide mononucleotide
-
inhibition of the NADase activity
Hg2+

-
complete inhibition at 2 mM; inhibition of NADase and adenosine diphosphate cyclase
Hg2+
-
10 mM HgCl2, 70% inhibition
additional information

-
not inhibited by rac-taxifolin, rac-catechin, piceatannol, and trans-resveratrol
-
additional information
-
NADase inhibitor from Pseudomonas putida KB1
-
additional information
-
high resistance to inhibition by nicotinamide
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Adenoma
The expression of messenger RNA for ADP-ribosyl cyclase in aldosterone-producing adenomas.
adenylate cyclase deficiency
An enzymatic alteration secondary to adenylyl cyclase deficiency in the cr-1 (crisp) mutant of Neurospora crassa: nicotinamide adenine dinucleotide (phosphate) glycohydrolase overproduction.
Anemia
Erythrocyte CD38 as a prognostic marker in cancer.
Brain Injuries
Perinatal hypoxic-ischemic brain injury affects the glutamatergic signal transduction coupled with neuronal ADP-ribosyl cyclase activity.
Cardiomegaly
Inhibition of ADP-ribosyl cyclase attenuates angiotensin II-induced cardiac hypertrophy.
Diabetic Nephropathies
Role of kidney ADP-ribosyl cyclase in diabetic nephropathy.
Glioma
Muscarinic receptor-mediated dual regulation of ADP-ribosyl cyclase in NG108-15 neuronal cell membranes.
Glioma
Signal transduction from bradykinin, angiotensin, adrenergic and muscarinic receptors to effector enzymes, including ADP-ribosyl cyclase.
Glioma
Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells.
Lupus Erythematosus, Systemic
CD38 polymorphisms in Spanish patients with systemic lupus erythematosus.
Multiple Myeloma
Daratumumab and Nanobody-Based Heavy Chain Antibodies Inhibit the ADPR Cyclase but not the NAD+ Hydrolase Activity of CD38-Expressing Multiple Myeloma Cells.
Myocardial Ischemia
Myocardial ischemia and reperfusion reduce the levels of cyclic ADP-ribose in rat myocardium.
Neoplasms
cADP-ribose/ryanodine channel/Ca2+-release signal transduction pathway in mesangial cells.
Neoplasms
CD38 and Regulation of the Immune Response Cells in Cancer.
Neoplasms
Changes in NAD/ADP-ribose metabolism in rectal cancer.
Neoplasms
Cyclic ADP-ribose as a potential second messenger for neuronal Ca2+ signaling.
Neoplasms
Erythrocyte CD38 as a prognostic marker in cancer.
Nervous System Diseases
Role of ADP-ribosyl cyclase in the pathogenesis of neurological disorders after coronary artery bypass surgery and experimental ischemia.
Neuroblastoma
Bradykinin activates ADP-ribosyl cyclase in neuroblastoma cells: intracellular concentration decrease in NAD and increase in cyclic ADP-ribose.
Neuroblastoma
Muscarinic receptor-mediated dual regulation of ADP-ribosyl cyclase in NG108-15 neuronal cell membranes.
Neuroblastoma
Signal transduction from bradykinin, angiotensin, adrenergic and muscarinic receptors to effector enzymes, including ADP-ribosyl cyclase.
Neuroblastoma
Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells.
Rectal Neoplasms
Changes in NAD/ADP-ribose metabolism in rectal cancer.
Tuberculosis
[NAD(P)-glycohydrolase in tuberculosis bacteria. A contribution to the mechanism of action INH]
Uterine Cervical Neoplasms
Increase of NAD glycohydrolase activity in uterine cervix cancers is caused by infiltration of lymphocytes.
Whooping Cough
Abscisic acid is an endogenous cytokine in human granulocytes with cyclic ADP-ribose as second messenger.
Whooping Cough
Abscisic acid is an endogenous stimulator of insulin release from human pancreatic islets with cyclic ADP ribose as second messenger.
Whooping Cough
Recombinant human serotonin 5A receptors stably expressed in C6 glioma cells couple to multiple signal transduction pathways.
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