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Literature summary for 3.2.2.6 extracted from

  • Congleton, J.; Jiang, H.; Malavasi, F.; Lin, H.; Yen, A.
    ATRA-induced HL-60 myeloid leukemia cell differentiation depends on the CD38 cytosolic tail needed for membrane localization, but CD38 enzymatic activity is unnecessary (2011), Exp. Cell Res., 317, 910-919.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.2.6

Protein Variants

Protein Variants Comment Organism
E226Q the mutation cripples enzymatic activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
arabinosyl 2'-fluoro-2'-deoxy-NAD suicide substrate that inhibits CD38 ectoenzyme activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane CD38 is a type II membrane protein with an extracellular C-terminal enzymatic domain with NADase/NADPase and ADPR cyclase activity and a short cytoplasmic N-terminal tail Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NGD+ + H2O
-
 Homo sapiens cyclic GDP-ribose
-
 ?

Synonyms

Synonyms Comment Organism
ADP-ribosyl cyclase
-
 Homo sapiens
ADPR cyclase
-
 Homo sapiens
CD38
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens 0.001 mM ATRA induces CD38 expression up

General Information

General Information Comment Organism
physiological function leukocyte antigen CD38 expression is an early marker of all-trans retinoic acid-stimulated differentiation in the leukemic cell line HL-60 where CD38 promotes induced myeloid maturation when overexpressed. The ability of CD38 to propel all-trans retinoic acid-induced myeloid differentiation and G1/0 arrest is unimpaired by loss of its ectoenzymeactivity Homo sapiens