Literature summary for 3.2.2.6 extracted from

Chini, C.; Hogan, K.A.; Warner, G.M.; Tarrago, M.G.; Peclat, T.R.; Tchkonia, T.; Kirkland, J.L.; Chini, E.
The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline (2019), Biochem. Biophys. Res. Commun., 513, 486-493 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P28907	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HUVEC cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
CD38	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	no induction of CD38 mRNA by senescence itself. Cytokines and chemokines expressed by senescent cells induce CD38 expression in macrophages	additional information

General Information

General Information	Comment	Organism
physiological function	senescent cells do not have high expression of CD38. The senescent associated secretory phenotype factors secreted by senescent cells induce CD38 mRNA and protein expression and increase CD38-NADase activity in non-senescent cells such as endothelial cells or bone marrow derived macrophages	Homo sapiens

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Release 2023.1 (January 2023)