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Literature summary for 3.2.2.6 extracted from
- Cyclic ADP-ribose and NAADP: fraternal twin messengers for calcium signaling (2011), Sci. China Life Sci., 54, 699-711.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Mus musculus | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lymphocyte | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cyclic ADP-ribose + H2O | - |
Mus musculus | ADP-ribose | - |
? |  |
| NAD+ + H2O | the cyclization and hydrolysis of NAD(P)+ occur optimally at physiological pH | Mus musculus | cyclic ADP-ribose + nicotinamide + H+ | - |
? | |
| NADP+ + nicotinic acid | this reaction occurs only in acidic pH | Mus musculus | nicotinic acid adenine dinucleotide phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CD38 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | CD38 knockout mice manifest multiple defects relating to Ca2+ signaling, including that of insulin secretion, hormonal signaling in pancreatic acinar cells, migration of dendritic cell precursors, bone resorption, airway responsiveness, alpha-adrenoceptor signaling in aorta, cardiac hypertrophy, susceptibility to bacterial infection, as well as social behavior in mice through modulation of oxytocin secretion | Mus musculus |
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Release 2023.1 (January 2023)
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