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5'-(4-fluorosulfonylbenzoyl)adenosine + H2O
5-fluorosulfonylbenzoyl-D-ribose + adenine
Substrates: -
Products: -
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5'-adenosylcysteine + H2O
adenine + S-ribosylcysteine
Substrates: -
Products: -
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5'-butylthioadenosine + H2O
5-butylthio-D-ribose + adenine
5'-butylthioadenosine + H2O
adenine + 5-butylthio-D-ribose
-
Substrates: 25% activity compared to 5'-methylthioadenosine
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5'-chloroadenosine + H2O
5-chloro-D-ribose + adenine
-
Substrates: -
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5'-chloroadenosine + H2O
adenine + 5-chloro-D-ribose
-
Substrates: 4% activity compared to 5'-methylthioadenosine
Products: -
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5'-deoxy-5'-(difluoromethylthio)adenosine + H2O
5-deoxy-5-(difluoromethylthio)-D-ribose + adenine
5'-deoxy-5'-(monofluoromethylthio)adenosine + H2O
5-deoxy-5-(monofluoromethylthio)-D-ribose + adenine
5'-deoxy-5'-(trifluoromethylthio)adenosine + H2O
5-deoxy-5-(trifluoromethylthio)-D-ribose + adenine
5'-deoxy-5'-isobutylthio-adenosine + H2O
5-isobutylthio-D-ribose + adenine
-
Substrates: 1-butanol buffer/propan-2-ol buffer
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5'-deoxy-5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
5'-deoxy-5'-methylthioadenosine + H2O
?
-
Substrates: -
Products: -
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5'-deoxy-5'-propylthioadenosine + H2O
5-propylthio-D-ribose + adenine
5'-deoxy-5'-S-adenosyl-L-cysteine + H2O
S-(5-deoxy-5-D-ribosyl)-L-cysteine + adenine
-
Substrates: relative activity 95.2%
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5'-deoxy-5'-S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-5-D-ribosyl)-L-homoscysteine + adenine
-
Substrates: substrate analogue, relative activity 95.8%
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5'-deoxy-5'-thioethanoladenosine + H2O
?
-
Substrates: relative activity 98%
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5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
5'-ethylthio-2-aminoadenosine + H2O
5-ethylthio-D-ribose + 2-aminoadenosine
-
Substrates: 1-butanol buffer/propan-2-ol buffer
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5'-ethylthioadenosine + H2O
5-ethylthio-D-ribose + adenine
5'-ethylthioadenosine + H2O
adenine + 5-ethylthio-D-ribose
-
Substrates: 40% activity compared to 5'-methylthioadenosine
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5'-ethylthioinosine + H2O
5-ethylthio-D-ribose + hypoxanthine
-
Substrates: 1-butanol buffer
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5'-iodoadenosine + H2O
adenine + 5-iodo-D-ribose
-
Substrates: 28% activity compared to 5'-methylthioadenosine
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5'-iodothioadenosine + H2O
5-iodothio-D-ribose + adenine
5'-isobutylthio-3-deaza-adenosine + H2O
5-isobutylthio-D-ribose + 3-deazadenosine
-
Substrates: 1-butanol buffer/propan-2-ol buffer
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5'-isobutylthioadenosine + H2O
5-isobutylthioribose + adenine
-
Substrates: -
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5'-isobutylthioadenosine + H2O
?
-
Substrates: 52% activity compared to 5'-methylthioadenosine
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5'-isobutylthioadenosine + H2O
adenine + 5-isobutylthio-D-ribose
-
Substrates: 17% activity compared to 5'-methylthioadenosine
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5'-isobutylthioinosine + H2O
5-isobutylthio-D-ribose + hypoxanthine
-
Substrates: 1-butanol buffer
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5'-isopropylthioadenosine + H2O
5-isopropylthio-D-ribose + adenine
Substrates: -
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5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
5'-methylthioadenosine + H2O
?
5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
5'-methylthioarabinosyladenine + H2O
5-methylthioarabinose + adenine
-
Substrates: 1-butanol buffer/propan-2-ol buffer
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5'-methylthioinosine + H2O
5-methylthio-D-ribose + hypoxanthine
5'-n-butylthioadenosine + H2O
5-n-butylthio-D-ribose + adenine
-
Substrates: 1-butanol buffer
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5'-n-butylthioadenosine + H2O
?
-
Substrates: 40% activity compared to 5'-methylthioadenosine
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5'-n-butylthioinosine + H2O
5-n-butylthio-D-ribose + hypoxanthine
-
Substrates: 1-butanol buffer
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5'-phenylthioadenosine + H2O
5-phenylthio-D-ribose + adenine
5'-phenylthioadenosine + H2O
adenine + 5-phenylthio-D-ribose
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Substrates: 12% activity compared to 5'-methylthioadenosine
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5'-propylthioadenosine + H2O
5-propylthio-D-ribose + adenine
Substrates: -
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6-amino-6-deoxyfutalosine + H2O
3-{3-[(2R,3S,4R,5R)-3,4,5-trihydroxytetrahydrofuran-2-yl]propanoyl}benzoic acid + 9H-purine-6-amine
6-amino-6-deoxyfutalosine + H2O
adenine + dehypoxanthinyl futalosine
Substrates: -
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adenosine + H2O
adenine + D-ribose
-
Substrates: -
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S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
S-adenosyl-L-homocysteine + H2O
S-D-ribosyl-L-homocysteine + adenine
S-adenosyl-L-homocysteine + H2O
S-ribosyl-L-homocysteine + adenine
S-adenosylhomocysteine + H2O
adenine + S-ribosylhomocysteine
S-adenosylmercaptoethanol + H2O
?
-
Substrates: 1-butanol buffer/propan-2-ol buffer
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S-inosylmercaptoethanol + H2O
?
-
Substrates: propan-2-ol buffer
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S-isobutyl-5'-thioadenosine + H2O
5-S-(2-methylpropyl)-5-thio-beta-D-ribofuranose + adenine
Substrates: -
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S-methyl-5'-thioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
additional information
?
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5'-butylthioadenosine + H2O
5-butylthio-D-ribose + adenine
-
Substrates: -
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5'-butylthioadenosine + H2O
5-butylthio-D-ribose + adenine
Substrates: -
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5'-deoxy-5'-(difluoromethylthio)adenosine + H2O
5-deoxy-5-(difluoromethylthio)-D-ribose + adenine
-
Substrates: DFMTA, fluorinated substrate analogue
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5'-deoxy-5'-(difluoromethylthio)adenosine + H2O
5-deoxy-5-(difluoromethylthio)-D-ribose + adenine
-
Substrates: DFMTA, fluorinated substrate analogue
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5'-deoxy-5'-(monofluoromethylthio)adenosine + H2O
5-deoxy-5-(monofluoromethylthio)-D-ribose + adenine
-
Substrates: MFMTA , fluorinated analogue of MTA
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5'-deoxy-5'-(monofluoromethylthio)adenosine + H2O
5-deoxy-5-(monofluoromethylthio)-D-ribose + adenine
-
Substrates: MFMTA , fluorinated analogue of MTA
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5'-deoxy-5'-(trifluoromethylthio)adenosine + H2O
5-deoxy-5-(trifluoromethylthio)-D-ribose + adenine
-
Substrates: TFMTA, fluorinated substrate analogue
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5'-deoxy-5'-(trifluoromethylthio)adenosine + H2O
5-deoxy-5-(trifluoromethylthio)-D-ribose + adenine
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Substrates: TFMTA, fluorinated substrate analogue
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5'-deoxy-5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
Substrates: -
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5'-deoxy-5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
Substrates: -
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5'-deoxy-5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
Substrates: -
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5'-deoxy-5'-propylthioadenosine + H2O
5-propylthio-D-ribose + adenine
-
Substrates: -
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5'-deoxy-5'-propylthioadenosine + H2O
5-propylthio-D-ribose + adenine
-
Substrates: 1-butanol buffer/propan-2-ol buffer
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5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
Substrates: i.e. DOA, MTAN can rapidly hydrolyse DOA
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5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
Substrates: -
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5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
Substrates: 1-butanol buffer
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5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
Substrates: -
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5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
Substrates: -
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5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
Substrates: -
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5'-ethylthioadenosine + H2O
5-ethylthio-D-ribose + adenine
-
Substrates: -
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5'-ethylthioadenosine + H2O
5-ethylthio-D-ribose + adenine
-
Substrates: 1-butanol buffer
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5'-ethylthioadenosine + H2O
5-ethylthio-D-ribose + adenine
Substrates: -
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5'-iodothioadenosine + H2O
5-iodothio-D-ribose + adenine
-
Substrates: -
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5'-iodothioadenosine + H2O
5-iodothio-D-ribose + adenine
Substrates: -
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5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
Substrates: -
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5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
Substrates: 100% activity
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5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
Substrates: Pfs protein and Bgp protein display 100% activity towards 5'-methylthioadenosine
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5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
Substrates: -
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5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
Substrates: -
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5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
Substrates: -
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5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
Substrates: -
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5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
Substrates: -
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5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
Substrates: -
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5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
Substrates: -
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5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
Substrates: -
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5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
Substrates: -
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5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
Substrates: -
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5'-methylthioadenosine + H2O
?
-
Substrates: -
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5'-methylthioadenosine + H2O
?
-
Substrates: -
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5'-methylthioadenosine + H2O
?
-
Substrates: -
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5'-methylthioadenosine + H2O
?
-
Substrates: -
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5'-methylthioadenosine + H2O
?
-
Substrates: -
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5'-methylthioadenosine + H2O
?
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Substrates: 100% activity
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5'-methylthioadenosine + H2O
?
-
Substrates: -
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5'-methylthioadenosine + H2O
?
-
Substrates: -
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5'-methylthioadenosine + H2O
?
-
Substrates: -
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5'-methylthioadenosine + H2O
?
Ochromonas malhamensis
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Substrates: -
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5'-methylthioadenosine + H2O
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-
Substrates: -
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5'-methylthioadenosine + H2O
?
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Substrates: enzyme activity increases parallel to ethylene biosynthesis during ripening or in wounded tissue, basal activity level of the enzyme in intact tissue reflects the synthesis of polyamines
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5'-methylthioadenosine + H2O
?
-
Substrates: -
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5'-methylthioadenosine + H2O
?
-
Substrates: -
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5'-methylthioadenosine + H2O
?
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Substrates: enzyme activity increases parallel to ethylene biosynthesis during ripening or in wounded tissue, basal activity level of the enzyme in intact tissue reflects the synthesis of polyamines
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5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
Substrates: -
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5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
Substrates: -
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5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
Substrates: -
Products: -
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5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
Substrates: -
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5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
Substrates: -
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5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
Substrates: -
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5'-methylthioinosine + H2O
5-methylthio-D-ribose + hypoxanthine
-
Substrates: -
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5'-methylthioinosine + H2O
5-methylthio-D-ribose + hypoxanthine
-
Substrates: maximal velocity about 50-times lower than for 5'-methylthioadenosine
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5'-phenylthioadenosine + H2O
5-phenylthio-D-ribose + adenine
-
Substrates: -
Products: -
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5'-phenylthioadenosine + H2O
5-phenylthio-D-ribose + adenine
Substrates: -
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6-amino-6-deoxyfutalosine + H2O
3-{3-[(2R,3S,4R,5R)-3,4,5-trihydroxytetrahydrofuran-2-yl]propanoyl}benzoic acid + 9H-purine-6-amine
Substrates: -
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6-amino-6-deoxyfutalosine + H2O
3-{3-[(2R,3S,4R,5R)-3,4,5-trihydroxytetrahydrofuran-2-yl]propanoyl}benzoic acid + 9H-purine-6-amine
Substrates: -
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S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
Substrates: 14% activity compared to 5'-methylthioadenosine
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S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
Substrates: -
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S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
Substrates: -
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S-adenosyl-L-homocysteine + H2O
S-D-ribosyl-L-homocysteine + adenine
Substrates: -
Products: -
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S-adenosyl-L-homocysteine + H2O
S-D-ribosyl-L-homocysteine + adenine
Substrates: -
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S-adenosyl-L-homocysteine + H2O
S-ribosyl-L-homocysteine + adenine
Substrates: -
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S-adenosyl-L-homocysteine + H2O
S-ribosyl-L-homocysteine + adenine
-
Substrates: -
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S-adenosyl-L-homocysteine + H2O
S-ribosyl-L-homocysteine + adenine
-
Substrates: -
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S-adenosyl-L-homocysteine + H2O
S-ribosyl-L-homocysteine + adenine
-
Substrates: -
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S-adenosylhomocysteine + H2O
adenine + S-ribosylhomocysteine
-
Substrates: -
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S-adenosylhomocysteine + H2O
adenine + S-ribosylhomocysteine
-
Substrates: -
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S-adenosylhomocysteine + H2O
adenine + S-ribosylhomocysteine
-
Substrates: -
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S-adenosylhomocysteine + H2O
adenine + S-ribosylhomocysteine
Substrates: 15.9% of the rate with 5'-methylthioadenosine
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S-methyl-5'-thioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
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Substrates: almost completely preferred substrate
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S-methyl-5'-thioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
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Substrates: -
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S-methyl-5'-thioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
Substrates: -
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S-methyl-5'-thioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
Substrates: -
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S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
Substrates: -
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S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
Substrates: -
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S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
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Substrates: preferred substrate
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S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
Substrates: -
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S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
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Substrates: preferred substrate
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S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
Substrates: -
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S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
Substrates: -
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S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
Substrates: -
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S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
Substrates: -
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S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
Substrates: -
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S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
Substrates: -
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S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
Substrates: -
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S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
Substrates: -
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S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
Substrates: -
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S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
Substrates: -
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S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
Substrates: -
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S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
Substrates: -
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S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
Substrates: -
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additional information
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-
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Substrates: no substrate: S-adenosylhomocysteine, adenosine
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additional information
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-
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Substrates: no activity towards S-adenosyl-L-homocysteine and adenosine
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additional information
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Substrates: AtMTAN2 is dual-substrate specific and is responsible for the hydrolysis of 5'-methylthioadenosine and S-adenosylhomocysteine to adenine and their corresponding thioriboses, overview
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additional information
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Substrates: dynamics are an important factor in substrate selection in MTAN, overview. Substrate binding induces a favourable entropic change in AtMTAN1
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additional information
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Substrates: substrate specificities of isozymes, isozyme AtMTAN2 is also active with S-adenosyl-L-homocysteine, EC 3.2.2.9, overview. Isozyme AtMTAN2 shows markedly broad substrate specificity for hydrolysis of S-adenosyl-L-homocysteine, while isozyme AtMTAN1 does not
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additional information
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Substrates: the enzyme also shows weak hydrolytic activity with S-adenosylhomocysteine
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additional information
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Substrates: enzyme is involved in two catabolic reactions: irreversible cleavage of the glycosidic bond of 5'-methylthioadenoside and cleavago of the glcyosidic bond of S-adenosylhomocysteine
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additional information
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Substrates: key role in biological methylation, polyamine biosynthesis, methionine recycling and bacterial quorum sensing
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additional information
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Substrates: MTAN is dual-substrate specific and is responsible for the hydrolysis of 5'-methylthioadenosine and S-adenosylhomocysteine to adenine and their corresponding thioriboses, overview
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additional information
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Substrates: MTAN restores the activity of three S-adenosyl-L-methionine utilizing enzymes, biotin synthase, lipoyl synthase and tyrosine lyase, that are inhibited by the highly reactive 5'-deoxyadenosyl radical, overview
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additional information
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Substrates: substrate binding, specificity and dynamics, overview. Substrate binding induces a unfavourable entropic change
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additional information
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Substrates: no activity toward 5'-methylthioinosine, 5'-isobutylthioinosine, 5'-isobutylthio-3-deaza-adenosine, 5'-methylthio-3-deaza-adenosine, 5'-chloroformycin, 5'-methylthioformycin, 5'-ethylthiotubercidin, S-tubercidinylhomocysteine, S-inosyl-L-homocysteine, S-guanosyl-L-homocysteine, S-cytidylhomocysteine, S-8-aza adenosyl-L-homocysteine, S-n-methyl-3-deaza-adenosyl-L-homocysteine, S-n6-dimethyl-3-deaza-adenosyl-L-homocysteine, sinefungin, S-adenosyl-L-homocysteine dialdehyde, and acyclic adenosyl-L-homocysteine
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Substrates: the enzyme catalyzes the hydrolytic cleavage of adenine from methylthioadenosine
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Substrates: broad substrate specificity
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Substrates: broad substrate specificity
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Substrates: the enzyme catalyzes the hydrolytic cleavage of adenine from methylthioadenosine
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Substrates: the enzyme catalyzes the hydrolytic cleavage of adenine from methylthioadenosine
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