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Literature summary for 3.2.2.16 extracted from

  • Challand, M.R.; Ziegert, T.; Douglas, P.; Wood, R.J.; Kriek, M.; Shaw, N.M.; Roach, P.L.
    Product inhibition in the radical S-adenosylmethionine family (2009), FEBS Lett., 583, 1358-1362.
    View publication on PubMed
Search for more literature for 3.2.2.16

Inhibitors

Inhibitors Comment Organism Structure
additional information MTAN is not inhibited by the highly reactive 5'-deoxyadenosyl radical Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Michelis-Menten kinetics, substrate 5'-deoxyadenosine Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-methyl-5'-thioadenosine + H2O Escherichia coli
-
 S-methyl-5-thio-D-ribose + adenine
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-deoxyadenosine + H2O i.e. DOA, MTAN can rapidly hydrolyse DOA Escherichia coli 5-deoxy-D-ribose + adenine
-
 ?
additional information MTAN restores the activity of three S-adenosyl-L-methionine utilizing enzymes, biotin synthase, lipoyl synthase and tyrosine lyase, that are inhibited by the highly reactive 5'-deoxyadenosyl radical, overview Escherichia coli ?
-
 ?
S-methyl-5'-thioadenosine + H2O
-
 Escherichia coli S-methyl-5-thio-D-ribose + adenine
-
 ?

Synonyms

Synonyms Comment Organism
5'-methylthioadenosine nucleosidase
-
 Escherichia coli
MTAN
-
 Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Escherichia coli