Literature summary for 3.2.2.16 extracted from

Evans, G.B.; Furneaux, R.H.; Greatrex, B.; Murkin, A.S.; Schramm, V.L.; Tyler, P.C.
Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases (2008), J. Med. Chem., 51, 948-956.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-[(9-deazaadenin-9-yl)methyl]-3-methylthiomethylazetidine	transition state analogue inhibitor, comparison with inhibition of Streptococcus pneumoniae enzyme and several methylthioadenosine phosphorylases	Escherichia coli
1-[(9-deazaadenin-9-yl)methyl]-3-methylthiomethylazetidine	transition state analogue inhibitor, comparison with inhibition of Escherichia coli enzyme and several methylthioadenosine phosphorylases	Streptococcus pneumoniae
1-[(9-deazaadenin-9-yl)methyl]-3-methylthiomethylazetidine-3-methanol	transition state analogue inhibitor, comparison with inhibition of Streptococcus pneumoniae enzyme and several methylthioadenosine phosphorylases	Escherichia coli
1-[(9-deazaadenin-9-yl)methyl]-3-methylthiomethylazetidine-3-methanol	transition state analogue inhibitor, comparison with inhibition of Escherichia coli enzyme and several methylthioadenosine phosphorylases	Streptococcus pneumoniae
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A	i.e. MT-DADMe-ImmA, transition state analogue inhibitor, comparison with inhibition of Streptococcus pneumoniae enzyme and several methylthioadenosine phosphorylases	Escherichia coli
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A	i.e. MT-DADMe-ImmA, transition state analogue inhibitor, comparison with inhibition of Escherichia coli enzyme and several methylthioadenosine phosphorylases	Streptococcus pneumoniae

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-
Streptococcus pneumoniae	-	-	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000000048	-	methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A	-	Escherichia coli
0.00000045	-	1-[(9-deazaadenin-9-yl)methyl]-3-methylthiomethylazetidine	-	Escherichia coli
0.00000084	-	1-[(9-deazaadenin-9-yl)methyl]-3-methylthiomethylazetidine-3-methanol	-	Escherichia coli
0.000084	-	1-[(9-deazaadenin-9-yl)methyl]-3-methylthiomethylazetidine	-	Streptococcus pneumoniae
0.00015	-	1-[(9-deazaadenin-9-yl)methyl]-3-methylthiomethylazetidine-3-methanol	-	Streptococcus pneumoniae

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Release 2023.1 (January 2023)