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ATP + a protein
ADP + a phosphoprotein
ATP + a protein
ADP + phosphorylated protein
-
-
-
-
?
ATP + Akt
ADP + phosphorylated Akt
ATP + Bcl-xL
ADP + phosphorylated Bcl-xL
-
recombinant human substrate, recombinant isozymes PKCepsilon and PKCzeta
-
-
?
ATP + Btk
ADP + phosphorylated Btk
ATP + GluR6 kainate receptor subunit
ADP + phosphorylated GluR6 kainate receptor subunit
-
two specific residues on the GluR6 C terminus, Ser846 and Ser868, are phosphorylated by protein kinase C, PKC phosphorylation of GluR6 retains GluR6 in the endoplasmic reticulum
-
-
?
ATP + insulin receptor
ADP + phosphorylated insulin receptor
-
isozyme PKCalpha
-
-
?
ATP + IRS
ADP + phosphorylated IRS
-
isozymes PKCalpha and PKCdelta, phosphorylation on Ser307
-
-
?
ATP + myristoylated alanine-rich C kinase substrate
ADP + phosphorylated myristoylated alanine-rich C kinase substrate
ATP + Par-3
ADP + phosphorylated Par-3
-
-
-
?
ATP + phosphoinositide-dependent kinase
ADP + phosphorylated phosphoinositide-dependent kinase
ATP + poly(ADP-ribose) polymerase-1
ADP + phosphorylated poly(ADP-ribose) polymerase-1
-
-
-
-
?
ATP + protein
ADP + phosphoprotein
autophosphorylation
-
-
?
ATP + transient receptor potential vanilloid 5
ADP + phosphorylated transient receptor potential vanilloid 5
-
-
-
-
?
ATP + vasodilator-stimulated phosphoprotein
ADP + phosphorylated vasodilator-stimulated phosphoprotein
-
phosphorylation at Ser157
-
-
?
Nepsilon-(benzyl)-ATP + histone 3
ADP + phosphorylated histone 3
-
-
-
-
?
Nepsilon-(benzyl)-ATP + RFARKGSLRQKNV
Nepsilon-(benzyl)-ADP + RFARKGpSLRQKNV
-
-
-
-
?
additional information
?
-
ATP + a protein
ADP + a phosphoprotein
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
?
ATP + Akt
ADP + phosphorylated Akt
-
phosphorylation by PKC isozymes at Ser473, regulation of the phosphorylation activity by PKCbetaII in mast cells stimulated by stem cell factor or interaleukin-3, and in serum-stimulated fibroblasts, and in antigen-receptor stimulated T- or B-lymphocytes, overview
-
-
?
ATP + Akt
ADP + phosphorylated Akt
-
Akt substrate is protein kinase B, phosphorylation by PKC isozymes at Ser473 involving phorbol esters
-
-
?
ATP + Akt
ADP + phosphorylated Akt
-
phosphorylation on Ser473 by isozyme PKCbetaII
-
-
?
ATP + Btk
ADP + phosphorylated Btk
-
specific phosphorylation leads to inhibition of Btk membrane translocation and activation and the downstream events that promote PKCbeta activation, mechanism, overview
-
-
?
ATP + Btk
ADP + phosphorylated Btk
-
specific phosphorylation of the tyrosine protein kinase at Ser180 within the Tec-homology domain
-
-
?
ATP + myristoylated alanine-rich C kinase substrate
ADP + phosphorylated myristoylated alanine-rich C kinase substrate
-
-
-
-
?
ATP + myristoylated alanine-rich C kinase substrate
ADP + phosphorylated myristoylated alanine-rich C kinase substrate
-
the substrate is involved in actincytoskeletal rearrangement in response to extra-cellular stimuli, phosphorylation of MARCKS is dramatically upregulated specifically in microglial cells after kainic acid-induced seizures, but not in other types of glial cells, overview
-
-
?
ATP + phosphoinositide-dependent kinase
ADP + phosphorylated phosphoinositide-dependent kinase
-
phosphoinositide-dependent kinases are conserved substrates of PKC
-
-
?
ATP + phosphoinositide-dependent kinase
ADP + phosphorylated phosphoinositide-dependent kinase
-
i.e. PDK, phosphorylation at Ser744 and Ser748 in the activation loop of the catalytic domain of PKD
-
-
?
additional information
?
-
protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the kappaB kinase alpha
-
-
?
additional information
?
-
overproduction of protein kinase C causes disordered growth control in rat fibroblasts, activation of PKC may be of central importance in the process of multistage carcinogenesis
-
-
?
additional information
?
-
phorbol ester receptor/protein kinase
-
-
?
additional information
?
-
-
phorbol ester receptor/protein kinase
-
-
?
additional information
?
-
PKC delta is involved in fundamental cellular functions regulated by diacylglycerols and mimicked by phorbol esters
-
-
?
additional information
?
-
-
PKC delta is involved in fundamental cellular functions regulated by diacylglycerols and mimicked by phorbol esters
-
-
?
additional information
?
-
protein kinase Cdelta controls self-antigen-induced B-cell tolerance
-
-
?
additional information
?
-
key regulatory role in a variety of cellular functions, including apoptosis, as well as cell growth and differentiation
-
-
?
additional information
?
-
-
key regulatory role in a variety of cellular functions, including apoptosis, as well as cell growth and differentiation
-
-
?
additional information
?
-
plays a central role in the control of proliferation and differentiation of a wide range of cell types by mediating the signal transduction response to hormones and growth factors
-
-
?
additional information
?
-
-
plays a central role in the control of proliferation and differentiation of a wide range of cell types by mediating the signal transduction response to hormones and growth factors
-
-
?
additional information
?
-
protein kinase C-epsilon increases growth and cause malignant transformation when overexpressed in NIH3T3 cells the catalytic domain of PKC-epsilon, in reciprocal PKC-delta and PKC-epsilon chimeras, is responsible for conferring tumorgenicity to NIH3T3 cells, whereas both regulatory and catalytic domains of PKC-epsilon contribute to in vitro transformation
-
-
?
additional information
?
-
-
protein kinase C-epsilon increases growth and cause malignant transformation when overexpressed in NIH3T3 cells the catalytic domain of PKC-epsilon, in reciprocal PKC-delta and PKC-epsilon chimeras, is responsible for conferring tumorgenicity to NIH3T3 cells, whereas both regulatory and catalytic domains of PKC-epsilon contribute to in vitro transformation
-
-
?
additional information
?
-
-
PKC is involved in cellular processes like cell growth, cytoskeleton remodelling, and gene expression regulation, emerging and diverse roles of PKC isozymes in immune cell signalling, i.e macrophage activation, signal transduction pathway of PKC in B- and T-lymphocytes, overview, isozyme theta is associated to NFkappa-B activation in T-cells
-
-
?
additional information
?
-
-
PKC mediates NF-kappaB activation, pathway overview, PKC isozymes have distinct roles in regulation of B-cell activation and function, e.g. signal transduction, isozyme PKCbeta is essential for B-cell antigen receptor-induced NF-kappaB activation and B-cell survival, isozyme PKCdelta is required for maintainance of self-reactive B-cell tolerance
-
-
?
additional information
?
-
-
PKCtheta is important in regulation of immune response in T-cells, overview, PKC is involved in NF-kappaB activation pathways in vivo, overview, PKCdelta acts as negative regulator by feedback inhibition of the CDgamma3 subunit important for immune response in T lymphocytes, overview, PKC isozymes are involved in signal transduction, and thereby in cell adhesion and migration, isozyme PKCtheta is recruited to the plasma membrane by a cytoskeleton-dependent mechanism regulating the Rac-1 guanine nucelotide exchange protein Vav-1
-
-
?
additional information
?
-
-
the enzyme is important in signal transduction from extracellular signals to intracellular responses involving the second messengers Ca2+ and diacylglycerol, processing mechanism and regulation overview, PKC is important in diverse biological functions, e.g. in cell proliferation, cell differentiation, immune response, cancer, and memory
-
-
?
additional information
?
-
-
PKC interacts with CARMA-1, involved in signaling from PKC to NF-kappaB
-
-
?
additional information
?
-
-
regulatory interactions of isozymes with other kinases, overview
-
-
?
additional information
?
-
-
substrate specificity of PKC isozymes, PKC isozymes interacting proteins, overview
-
-
?
additional information
?
-
-
involvement of isozyme PKCalpha in the early action of angiotensin II type 2 effects on neurite outgrowth in NG108-15 cells, the angiotensin II type 2-receptor inhibits PKC alpha and p21ras activity, inhibition of PKCalpha is not directly involved in the Rap1-MEK-p42/p44mapk cascade, overview
-
-
?
additional information
?
-
-
isozyme PKCdelta inhibits the production of proteolytic enzymes in murine mammary cells, the PKCdelta effect is mediated by the MEK/ERK pathway, overview
-
-
?
additional information
?
-
-
PKC isoform specificity of cholinergic potentiation of glucose-induced pulsatile 5-HT/insulin release from single mouse pancreatic islets, overview
-
-
?
additional information
?
-
-
PKC signalling has been suggested to play a role in Ca2+ entry, granule secretion, alphaIIbbeta3 activation and outside-in signalling, PKC also is involved in receptor desensitization, extrusion of intracellular Ca2+, secretion and actin-mediated filopodia formation, PKC negatively regulates platelet activation and the diverse processes in which active platelet are involved, detailed overview, PKC increases Ca2+ extrusion from the cytosol and desensitizes some G-protein coupled receptors, isozyme PKCdelta inhibits platelet aggregation by inhibiting VASP phosphorylation at Ser157, reducing filopodial extension, overview, PKCdelta is required for dense granule secretion following stimulation by thrombin, and plays a negative regulatory role in dense granule secretion when platelets are stimulated by convulxin, PKCtheta is also required for outside-in signalling and, as with PKCbeta, platelets deficient in PKCtheta do not fully spread on a fibrinogen-coated surface
-
-
?
additional information
?
-
-
regulation of PKC isozyme expression, overview, specific PKC isozymes act as transducers and modulators of insulin signaling, the activation of PKC isozymes by insulin is modified by several effectors, signaling cascade, overview, isozyme PKCalpha might play a role in insulin resistance, overview
-
-
?
additional information
?
-
-
PKCbetaII specifically binds to beta-actin
-
-
?
additional information
?
-
-
tumor necrosis factor alpha-converting enzyme activation is consequent to concomitant actions of intracellular signals mediated by protein kinase C and extracellular signal-regulated kinase as well as reduction of its endogenous inhibitor Timp3
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + a protein
ADP + a phosphoprotein
ATP + a protein
ADP + phosphorylated protein
-
-
-
-
?
ATP + Akt
ADP + phosphorylated Akt
-
phosphorylation by PKC isozymes at Ser473, regulation of the phosphorylation activity by PKCbetaII in mast cells stimulated by stem cell factor or interaleukin-3, and in serum-stimulated fibroblasts, and in antigen-receptor stimulated T- or B-lymphocytes, overview
-
-
?
ATP + Btk
ADP + phosphorylated Btk
-
specific phosphorylation leads to inhibition of Btk membrane translocation and activation and the downstream events that promote PKCbeta activation, mechanism, overview
-
-
?
ATP + myristoylated alanine-rich C kinase substrate
ADP + phosphorylated myristoylated alanine-rich C kinase substrate
-
the substrate is involved in actincytoskeletal rearrangement in response to extra-cellular stimuli, phosphorylation of MARCKS is dramatically upregulated specifically in microglial cells after kainic acid-induced seizures, but not in other types of glial cells, overview
-
-
?
ATP + phosphoinositide-dependent kinase
ADP + phosphorylated phosphoinositide-dependent kinase
-
phosphoinositide-dependent kinases are conserved substrates of PKC
-
-
?
ATP + vasodilator-stimulated phosphoprotein
ADP + phosphorylated vasodilator-stimulated phosphoprotein
-
phosphorylation at Ser157
-
-
?
additional information
?
-
ATP + a protein
ADP + a phosphoprotein
-
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
?
additional information
?
-
protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the kappaB kinase alpha
-
-
?
additional information
?
-
overproduction of protein kinase C causes disordered growth control in rat fibroblasts, activation of PKC may be of central importance in the process of multistage carcinogenesis
-
-
?
additional information
?
-
PKC delta is involved in fundamental cellular functions regulated by diacylglycerols and mimicked by phorbol esters
-
-
?
additional information
?
-
-
PKC delta is involved in fundamental cellular functions regulated by diacylglycerols and mimicked by phorbol esters
-
-
?
additional information
?
-
protein kinase Cdelta controls self-antigen-induced B-cell tolerance
-
-
?
additional information
?
-
key regulatory role in a variety of cellular functions, including apoptosis, as well as cell growth and differentiation
-
-
?
additional information
?
-
-
key regulatory role in a variety of cellular functions, including apoptosis, as well as cell growth and differentiation
-
-
?
additional information
?
-
plays a central role in the control of proliferation and differentiation of a wide range of cell types by mediating the signal transduction response to hormones and growth factors
-
-
?
additional information
?
-
-
plays a central role in the control of proliferation and differentiation of a wide range of cell types by mediating the signal transduction response to hormones and growth factors
-
-
?
additional information
?
-
protein kinase C-epsilon increases growth and cause malignant transformation when overexpressed in NIH3T3 cells the catalytic domain of PKC-epsilon, in reciprocal PKC-delta and PKC-epsilon chimeras, is responsible for conferring tumorgenicity to NIH3T3 cells, whereas both regulatory and catalytic domains of PKC-epsilon contribute to in vitro transformation
-
-
?
additional information
?
-
-
protein kinase C-epsilon increases growth and cause malignant transformation when overexpressed in NIH3T3 cells the catalytic domain of PKC-epsilon, in reciprocal PKC-delta and PKC-epsilon chimeras, is responsible for conferring tumorgenicity to NIH3T3 cells, whereas both regulatory and catalytic domains of PKC-epsilon contribute to in vitro transformation
-
-
?
additional information
?
-
-
PKC is involved in cellular processes like cell growth, cytoskeleton remodelling, and gene expression regulation, emerging and diverse roles of PKC isozymes in immune cell signalling, i.e macrophage activation, signal transduction pathway of PKC in B- and T-lymphocytes, overview, isozyme theta is associated to NFkappa-B activation in T-cells
-
-
?
additional information
?
-
-
PKC mediates NF-kappaB activation, pathway overview, PKC isozymes have distinct roles in regulation of B-cell activation and function, e.g. signal transduction, isozyme PKCbeta is essential for B-cell antigen receptor-induced NF-kappaB activation and B-cell survival, isozyme PKCdelta is required for maintainance of self-reactive B-cell tolerance
-
-
?
additional information
?
-
-
PKCtheta is important in regulation of immune response in T-cells, overview, PKC is involved in NF-kappaB activation pathways in vivo, overview, PKCdelta acts as negative regulator by feedback inhibition of the CDgamma3 subunit important for immune response in T lymphocytes, overview, PKC isozymes are involved in signal transduction, and thereby in cell adhesion and migration, isozyme PKCtheta is recruited to the plasma membrane by a cytoskeleton-dependent mechanism regulating the Rac-1 guanine nucelotide exchange protein Vav-1
-
-
?
additional information
?
-
-
the enzyme is important in signal transduction from extracellular signals to intracellular responses involving the second messengers Ca2+ and diacylglycerol, processing mechanism and regulation overview, PKC is important in diverse biological functions, e.g. in cell proliferation, cell differentiation, immune response, cancer, and memory
-
-
?
additional information
?
-
-
involvement of isozyme PKCalpha in the early action of angiotensin II type 2 effects on neurite outgrowth in NG108-15 cells, the angiotensin II type 2-receptor inhibits PKC alpha and p21ras activity, inhibition of PKCalpha is not directly involved in the Rap1-MEK-p42/p44mapk cascade, overview
-
-
?
additional information
?
-
-
isozyme PKCdelta inhibits the production of proteolytic enzymes in murine mammary cells, the PKCdelta effect is mediated by the MEK/ERK pathway, overview
-
-
?
additional information
?
-
-
PKC isoform specificity of cholinergic potentiation of glucose-induced pulsatile 5-HT/insulin release from single mouse pancreatic islets, overview
-
-
?
additional information
?
-
-
PKC signalling has been suggested to play a role in Ca2+ entry, granule secretion, alphaIIbbeta3 activation and outside-in signalling, PKC also is involved in receptor desensitization, extrusion of intracellular Ca2+, secretion and actin-mediated filopodia formation, PKC negatively regulates platelet activation and the diverse processes in which active platelet are involved, detailed overview, PKC increases Ca2+ extrusion from the cytosol and desensitizes some G-protein coupled receptors, isozyme PKCdelta inhibits platelet aggregation by inhibiting VASP phosphorylation at Ser157, reducing filopodial extension, overview, PKCdelta is required for dense granule secretion following stimulation by thrombin, and plays a negative regulatory role in dense granule secretion when platelets are stimulated by convulxin, PKCtheta is also required for outside-in signalling and, as with PKCbeta, platelets deficient in PKCtheta do not fully spread on a fibrinogen-coated surface
-
-
?
additional information
?
-
-
regulation of PKC isozyme expression, overview, specific PKC isozymes act as transducers and modulators of insulin signaling, the activation of PKC isozymes by insulin is modified by several effectors, signaling cascade, overview, isozyme PKCalpha might play a role in insulin resistance, overview
-
-
?
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Saijo, K.; Mecklenbrauker, I.; Santana, A.; et al.
Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha
J. Exp. Med.
195
1647-1652
2002
Mus musculus (P68404)
brenda
Mecklenbrauker, I.; Saijo, K.; Zheng, N.Y.; Leitges, M.; Tarakhovsky, A.
Protein kinase C delta controls self-antigen-induced B-cell tolerance
Nature
416
860-865
2002
Mus musculus (P28867)
brenda
Sakurai, Y.; Onishi, Y.; Tanimoto, Y.; Kizaki, H.
Novel protein kinase C delta isoform insensitive to caspase-3
Biol. Pharm. Bull.
24
973-977
2001
Mus musculus (P28867), Mus musculus
brenda
Sutton, R.B.; Sprang, S.R.
Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca2+
Structure
6
1395-1405
1998
Mus musculus (P68404)
brenda
Keranen, L.M.; Dutil, E.M.; Newton, A.C.
Protein kinase C is regulated in vivo by three functionally distinct phosphorylations
Curr. Biol.
5
1394-1403
1995
Mus musculus (P68404)
brenda
Zhang, J.; Wang, L.; Schwartz, J.; Bond, R.W.; Bishop, W.R.
Phosphorylation of Thr642 is an early event in the processing of newly synthesized protein kinase C beta 1 and is essential for its activation
J. Biol. Chem.
269
19578-19584
1994
Mus musculus (P68404)
brenda
Orr, J.W.; Newton, A.C.
Requirement for negative charge on "activation loop" of protein kinase C
J. Biol. Chem.
269
27715-27718
1994
Mus musculus (P68404)
brenda
Zhang, J.; Wang, L.; Petrin, J.; Bishop, W.R.; Bond, R.W.
Characterization of site-specific mutants altered at protein kinase C beta 1 isozyme autophosphorylation sites
Proc. Natl. Acad. Sci. USA
90
6130-6134
1993
Mus musculus (P68404)
brenda
Tang, Y.M.; Ashendel, C.L.
Isolation of cloned mouse protein kinase C beta-II cDNA and its sequence
Nucleic Acids Res.
18
5310
1990
Mus musculus (P68404), Mus musculus
brenda
Housey, G.M.; Johnson, M.D.; Hsiao, W.L.; O'Brian, C.A.; Murphy, J.P.; Kirschmeier, P.; Weinstein, I.B.
Overproduction of protein kinase C causes disordered growth control in rat fibroblasts
Cell
52
343-354
1988
Mus musculus (P68404)
brenda
Housey, G.M.; O'Brian, C.A.; Johnson, M.D.; Kirschmeier, P.; Weinstein, I.B.
Isolation of cDNA clones encoding protein kinase C: evidence for a protein kinase C-related gene family
Proc. Natl. Acad. Sci. USA
84
1065-1069
1987
Mus musculus (P68404)
brenda
Ono, Y.; Kurokawa, T.; Kawahara, K.; Nishimura, O.; Marumoto, R.; Igarashi, K.; Sugino, Y.; Kikkawa, U.; Ogita, K.; Nishizuka, Y.
Cloning of rat brain protein kinase C complementary DNA
FEBS Lett.
203
111-115
1986
Mus musculus (P68404)
brenda
Ono, Y.; Kurokawa, T.; Fujii, T.; Kawahara, K.; Igarashi, K.; Kikkawa, U.; Ogita, K.; Nishizuka, Y.
Two types of complementary DNAs of rat brain protein kinase C. Heterogeneity determined by alternative splicing
FEBS Lett.
206
347-352
1986
Mus musculus (P68404)
brenda
Knopf, J.L.; Lee, M.H.; Sultzman, L.A.; Kriz, R.W.; Loomis, C.R.; Hewick, R.M.; Bell, R.M.
Cloning and expression of multiple protein kinase C cDNAs
Cell
46
491-502
1986
Mus musculus (P63318), Mus musculus (P68404)
brenda
Le Good, J.A.; Ziegler, W.H.; Parekh, D.B.; Alessi, D.R.; Cohen, P.; Parker, P.J.
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
Science
281
2042-2045
1998
Mus musculus (P28867)
brenda
Zhang, G.; Kazanietz, M.G.; Blumberg, P.M.; Hurley, J.H.
Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester
Cell
81
917-924
1995
Mus musculus (P28867)
brenda
Mizuno, K.; Kubo, K.; Saido, T.C.; Akita, Y.; Osada, S.; Kuroki, T.; Ohno, S.; Suzuki, K.
Structure and properties of a ubiquitously expressed protein kinase C, nPKC delta
Eur. J. Biochem.
202
931-940
1991
Mus musculus (P28867), Mus musculus
brenda
Mischak, H.; Bodenteich, A.; Kolch, W.; Goodnight, J.; Hofer, F.; Mushinski, J.F.
Mouse protein kinase C-delta, the major isoform expressed in mouse hemopoietic cells: sequence of the cDNA, expression patterns, and characterization of the protein
Biochemistry
30
7925-7931
1991
Mus musculus (P28867), Mus musculus
brenda
Ono, Y.; Fujii, T.; Igarashi, K.; Kikkawa, U.; Ogita, K.; Nishizuka, Y.
Nucleotide sequences of cDNAs for alpha and gamma subspecies of rat brain protein kinase C
Nucleic Acids Res.
16
5199-5200
1988
Rattus norvegicus (P05696), Mus musculus (P63318)
brenda
Xu, R.X.; Pawelczyk, T.; Xia, T.H.; Brown, S.C.
NMR structure of a protein kinase C-gamma phorbol-binding domain and study of protein-lipid micelle interactions
Biochemistry
36
10709-10717
1997
Mus musculus (P63318)
brenda
Bowers, B.J.; Parham, C.L.; Sikela, J.M.; Wehner, J.M.
Isolation and sequence of a mouse brain cDNA coding for protein kinase C-gamma isozyme
Gene
123
263-265
1993
Mus musculus (P63318), Mus musculus
brenda
Chen, K.H.; Widen, S.G.; Wilson, S.H.; Huang, K.P.
Characterization of the 5'-flanking region of the rat protein kinase C gamma gene
J. Biol. Chem.
265
19961-19965
1990
Mus musculus (P63318)
brenda
Wang, Q.J.; Acs, P.; Goodnight, J.; Blumberg, P.M.; Mischak, H.; Mushinski, J.F.
The catalytic domain of PKC-epsilon, in reciprocal PKC-delta and -epsilon chimeras, is responsible for conferring tumorgenicity to NIH3T3 cells, whereas both regulatory and catalytic domains of PKC-epsilon contribute to in vitro transformation
Oncogene
16
53-60
1998
Mus musculus (P16054), Mus musculus
brenda
Schaap, D.; Parker, P.J.; Bristol, A.; Kriz, R.; Knopf, J.
Unique substrate specificity and regulatory properties of PKC-epsilon: a rationale for diversity
FEBS Lett.
243
351-357
1989
Mus musculus (P16054), Mus musculus
brenda
Staudinger, J.; Zhou, J.; Burgess, R.; Elledge, S.J.; Olson, E.N.
PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system
J. Cell Biol.
128
263-271
1995
Mus musculus (P20444), Mus musculus
brenda
Megidish, T.; Mazurek, N.
A mutant protein kinase C that can transform fibroblasts
Nature
342
807-811
1989
Mus musculus (P20444), Mus musculus
brenda
Rose-John, S.; Dietrich, A.; Marks, F.
Molecular cloning of mouse protein kinase C (PKC) cDNA from Swiss 3T3 fibroblasts
Gene
74
465-471
1988
Mus musculus (P20444), Mus musculus
brenda
Osada, S.; Mizuno, K.; Saido, T.C.; Akita, Y.; Suzuki, K.; Kuroki, T.; Ohno, S.
A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin
J. Biol. Chem.
265
22434-22440
1990
Mus musculus (P23298), Mus musculus
brenda
Goodnight, J.; Kazanietz, M.G.; Blumberg, P.M.; Mushinski, J.F.; Mischak, H.
The cDNA sequence, expression pattern and protein characteristics of mouse protein kinase C-zeta
Gene
122
305-311
1992
Mus musculus (Q02956), Mus musculus
brenda
Akimoto, K.; Mizuno, K.; Osada, S.; Hirai, S.; Tanuma, S.; Suzuki, K.; Ohno, S.
A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells
J. Biol. Chem.
269
12677-12683
1994
Mus musculus (Q62074), Mus musculus
brenda
Tan, S.L.; Parker, P.J.
Emerging and diverse roles of protein kinase C in immune cell signalling
Biochem. J.
376
545-552
2003
Mus musculus
brenda
Guo, B.; Su, T.T.; Rawlings, D.J.
Protein kinase C family functions in B-cell activation
Curr. Opin. Immunol.
16
367-373
2004
Mus musculus
brenda
Violin, J.D.; Newton, A.C.
Pathway illuminated: visualizing protein kinase C signaling
IUBMB Life
55
653-660
2003
Homo sapiens, Mus musculus
brenda
Kawakami, Y.; Nishimoto, H.; Kitaura, J.; Maeda-Yamamoto, M.; Kato, R.M.; Littman, D.R.; Rawlings, D.J.; Kawakami, T.
Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion
J. Biol. Chem.
279
47720-47725
2004
Mus musculus
brenda
Spitaler, M.; Cantrell, D.A.
Protein kinase C and beyond
Nat. Immunol.
5
785-790
2004
Caenorhabditis elegans, Homo sapiens, Solanum lycopersicum, Mus musculus
brenda
Harper, M.T.; Poole, A.W.
Isoform-specific functions of protein kinase C: the platelet paradigm
Biochem. Soc. Trans.
35
1005-1008
2007
Mus musculus
brenda
Baldeiras, I.E.; Santos, R.M.; Rosario, L.M.
Protein kinase C isoform specificity of cholinergic potentiation of glucose-induced pulsatile 5-HT/insulin release from mouse pancreatic islets
Biol. Res.
39
531-539
2006
Mus musculus
brenda
Xu, T.R.; He, G.; Dobson, K.; England, K.; Rumsby, M.
Phosphorylation at Ser729 specifies a Golgi localisation for protein kinase C epsilon (PKCepsilon) in 3T3 fibroblasts
Cell. Signal.
19
1986-1995
2007
Mus musculus
brenda
Grossoni, V.C.; Falbo, K.B.; Mauro, L.V.; Krasnapolski, M.A.; Kazanietz, M.G.; Bal De Kier Joffe, E.D.; Urtreger, A.J.
Protein kinase C delta inhibits the production of proteolytic enzymes in murine mammary cells
Clin. Exp. Metastasis
24
513-520
2007
Mus musculus
brenda
Beaudry, H.; Gendron, L.; Guimond, M.O.; Payet, M.D.; Gallo-Payet, N.
Involvement of protein kinase C alpha (PKC alpha) in the early action of angiotensin II type 2 (AT2) effects on neurite outgrowth in NG108-15 cells: AT2-receptor inhibits PKC alpha and p21ras activity
Endocrinology
147
4263-4272
2006
Mus musculus, Rattus norvegicus
brenda
Eun, S.Y.; Kim, E.H.; Kang, K.S.; Kim, H.J.; Jo, S.A.; Kim, S.J.; Jo, S.H.; Kim, S.J.; Blackshear, P.J.; Kim, J.
Cell type-specific upregulation of myristoylated alanine-rich C kinase substrate and protein kinase C-alpha, -beta I, -beta II, and -delta in microglia following kainic acid-induced seizures
Exp. Mol. Med.
38
310-319
2006
Mus musculus, Mus musculus C57BL/6
brenda
Saraiva, L.; Silva, R.D.; Pereira, G.; Goncalves, J.; Corte-Real, M.
Specific modulation of apoptosis and Bcl-xL phosphorylation in yeast by distinct mammalian protein kinase C isoforms
J. Cell Sci.
119
3171-3181
2006
Mus musculus, Rattus norvegicus
brenda
Sampson, S.R.; Cooper, D.R.
Specific protein kinase C isoforms as transducers and modulators of insulin signaling
Mol. Genet. Metab.
89
32-47
2006
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Cha, S.K.; Wu, T.; Huang, C.L.
Protein kinase C inhibits caveolae-mediated endocytosis of TRPV5
Am. J. Physiol. Renal Physiol.
294
F1212-F1221
2008
Mus musculus
brenda
Hegedus, C.; Lakatos, P.; Olah, G.; Toth, B.I.; Gergely, S.; Szabo, E.; Biro, T.; Szabo, C.; Virag, L.
Protein kinase C protects from DNA damage-induced necrotic cell death by inhibiting poly(ADP-ribose) polymerase-1
FEBS Lett.
582
1672-1678
2008
Mus musculus
brenda
Lam, J.S.; Wang, L.; Lin, L.; Chan, S.O.
Role of protein kinase C in selective inhibition of mouse retinal neurites during contacts with chondroitin sulfates
Neurosci. Lett.
434
150-154
2008
Mus musculus (P16054), Mus musculus (P20444), Mus musculus (P28867), Mus musculus (P63318), Mus musculus (P68404), Mus musculus
brenda
Fiorentino, L.; Vivanti, A.; Cavalera, M.; Marzano, V.; Ronci, M.; Fabrizi, M.; Menini, S.; Pugliese, G.; Menghini, R.; Khokha, R.; Lauro, R.; Urbani, A.; Federici, M.
Increased tumor necrosis factor alpha-converting enzyme activity induces insulin resistance and hepatosteatosis in mice
Hepatology
51
103-110
2010
Mus musculus
brenda
Nasu-Nishimura, Y.; Jaffe, H.; Isaac, J.T.; Roche, K.W.
Differential regulation of kainate receptor trafficking by phosphorylation of distinct sites on GluR6
J. Biol. Chem.
285
2847-2856
2010
Mus musculus
brenda
Rahman, G.M.; Shanker, S.; Lewin, N.E.; Kedei, N.; Hill, C.S.; Prasad, B.V.; Blumberg, P.M.; Das, J.
Identification of the activator-binding residues in the second cysteine-rich regulatory domain of protein kinase Ctheta (PKCtheta)
Biochem. J.
451
33-44
2013
Mus musculus
brenda
Pinzon-Guzman, C.; Zhang, S.S.; Barnstable, C.J.
Specific protein kinase C isoforms are required for rod photoreceptor differentiation
J. Neurosci.
31
18606-18617
2011
Mus musculus
brenda
Wang, C.; Shang, Y.; Yu, J.; Zhang, M.
Substrate recognition mechanism of atypical protein kinase Cs revealed by the structure of PKCiota in complex with a substrate peptide from Par-3
Structure
20
791-801
2012
Mus musculus (Q62074)
brenda
Kumar, V.; Weng, Y.C.; Geldenhuys, W.J.; Wang, D.; Han, X.; Messing, R.O.; Chou, W.H.
Generation and characterization of ATP analog-specific protein kinase Cdelta
J. Biol. Chem.
290
1936-1951
2015
Mus musculus
brenda
Liu, P.; Li, Y.; Qi, X.; Xu, J.; Liu, D.; Ji, X.; Chi, T.; Liu, H.; Zou, L.
Protein kinase C is involved in the neuroprotective effect of berberine against intrastriatal injection of quinolinic acid-induced biochemical alteration in mice
J. Cell. Mol. Med.
23
6343-6354
2019
Mus musculus
brenda
Goode, D.J.; Molliver, D.C.
Phospho-substrate profiling of Epac-dependent protein kinase C activity
Mol. Cell. Biochem.
456
167-178
2019
Mus musculus (P16054), Mus musculus (P20444), Mus musculus (P63318), Mus musculus
brenda