Activating Compound | Comment | Organism | Structure |
---|---|---|---|
12-O-Tetradecanoylphorbol 13-acetate | activates isozyme PKCepsilon | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expression of wild-type and mutant isozyme PKCepsilon in NIH3T3 fibroblasts as GFP-tagged proteins | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
S279A | site-directed mutagenesis of the isozyme PKCepsilon phosphorylation site results in altered subcellular localization not in the perinulcear/Golgi site | Mus musculus |
S279E | site-directed mutagenesis of the isozyme PKCepsilon phosphorylation site results in altered subcellular localization not in the perinulcear/Golgi site | Mus musculus |
S279T | site-directed mutagenesis of the isozyme PKCepsilon phosphorylation site results in altered subcellular localization not in the perinulcear/Golgi site | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | isozyme PKCepsilon in a perinuclear site is associated with the Golgi apparatus, phosphorylation of isozyme PKCepsilon at Ser279 is required for translocation to the nucleus during which the enzyme looses the phsophate group at Ser279, overview | Mus musculus | 5794 | - |
additional information | cell passage induces rapid translocation of isozyme PKCepsilon to the periphery where it appears to colocalize with F-actin, which renders the cells proliferative again while PKCepsilon return to the perinuclear site | Mus musculus | - |
- |
perinuclear space | isozyme PKCepsilon in a perinuclear site is associated with the Golgi apparatus, phosphorylation of isozyme PKCepsilon at Ser279 is required for translocation to the nucleus during which the enzyme looses the phsophate group at Ser279, overview | Mus musculus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
isozyme PKCepsilon | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation of isozyme PKCepsilon at Ser279 is required for translocation to the nucleus during which the enzyme looses the phsophate group at Ser279, overview | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
PKC | - |
Mus musculus |