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Literature summary for 2.7.11.13 extracted from

  • Xu, T.R.; He, G.; Dobson, K.; England, K.; Rumsby, M.
    Phosphorylation at Ser729 specifies a Golgi localisation for protein kinase C epsilon (PKCepsilon) in 3T3 fibroblasts (2007), Cell. Signal., 19, 1986-1995.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
12-O-Tetradecanoylphorbol 13-acetate activates isozyme PKCepsilon Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutant isozyme PKCepsilon in NIH3T3 fibroblasts as GFP-tagged proteins Mus musculus

Protein Variants

Protein Variants Comment Organism
S279A site-directed mutagenesis of the isozyme PKCepsilon phosphorylation site results in altered subcellular localization not in the perinulcear/Golgi site Mus musculus
S279E site-directed mutagenesis of the isozyme PKCepsilon phosphorylation site results in altered subcellular localization not in the perinulcear/Golgi site Mus musculus
S279T site-directed mutagenesis of the isozyme PKCepsilon phosphorylation site results in altered subcellular localization not in the perinulcear/Golgi site Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus isozyme PKCepsilon in a perinuclear site is associated with the Golgi apparatus, phosphorylation of isozyme PKCepsilon at Ser279 is required for translocation to the nucleus during which the enzyme looses the phsophate group at Ser279, overview Mus musculus 5794
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additional information cell passage induces rapid translocation of isozyme PKCepsilon to the periphery where it appears to colocalize with F-actin, which renders the cells proliferative again while PKCepsilon return to the perinuclear site Mus musculus
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perinuclear space isozyme PKCepsilon in a perinuclear site is associated with the Golgi apparatus, phosphorylation of isozyme PKCepsilon at Ser279 is required for translocation to the nucleus during which the enzyme looses the phsophate group at Ser279, overview Mus musculus
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Organism

Organism UniProt Comment Textmining
Mus musculus
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isozyme PKCepsilon
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation of isozyme PKCepsilon at Ser279 is required for translocation to the nucleus during which the enzyme looses the phsophate group at Ser279, overview Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
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Mus musculus
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Synonyms

Synonyms Comment Organism
PKC
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Mus musculus