Activating Compound | Comment | Organism | Structure |
---|---|---|---|
diacylglycerol | required, second messenger involved in PKC regulation | Mus musculus | |
diacylglycerol | required, second messenger involved in PKC regulation | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of GFP-tagged PKC | Mus musculus |
expression of GFP-tagged PKC | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of PKC isozyme-deletion mutant mice leading to important metabolic deficiencies in the mutant mice | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | bound to via second messengers and phorbol esters, the ligand-binding domains are required for membrane targeting | Mus musculus | 16020 | - |
membrane | bound to via second messengers and phorbol esters, the ligand-binding domains are required for membrane targeting | Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required, second messenger involved in PKC regulation, some isozymes are Ca2+-independent | Mus musculus | |
Ca2+ | required, second messenger involved in PKC regulation, some isozymes are Ca2+-independent | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme is important in signal transduction from extracellular signals to intracellular responses involving the second messengers Ca2+ and diacylglycerol, processing mechanism and regulation overview | ? | - |
? | |
additional information | Mus musculus | the enzyme is important in signal transduction from extracellular signals to intracellular responses involving the second messengers Ca2+ and diacylglycerol, processing mechanism and regulation overview, PKC is important in diverse biological functions, e.g. in cell proliferation, cell differentiation, immune response, cancer, and memory | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
several isozymes | - |
Mus musculus | - |
several isozymes | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is important in signal transduction from extracellular signals to intracellular responses involving the second messengers Ca2+ and diacylglycerol, processing mechanism and regulation overview | Homo sapiens | ? | - |
? | |
additional information | the enzyme is important in signal transduction from extracellular signals to intracellular responses involving the second messengers Ca2+ and diacylglycerol, processing mechanism and regulation overview, PKC is important in diverse biological functions, e.g. in cell proliferation, cell differentiation, immune response, cancer, and memory | Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | PKC domain composition | Mus musculus |
More | PKC domain composition | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PKC | - |
Mus musculus |
PKC | - |
Homo sapiens |