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Literature summary for 2.7.11.13 extracted from

  • Kumar, V.; Weng, Y.C.; Geldenhuys, W.J.; Wang, D.; Han, X.; Messing, R.O.; Chou, W.H.
    Generation and characterization of ATP analog-specific protein kinase Cdelta (2015), J. Biol. Chem., 290, 1936-1951.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.13

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-7 and Neuro2A cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
1-(tert-butyl)-3-(1-naphthyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine inhibits ATP analog-specific PKCdelta isoform Mus musculus
1-(tert-butyl)-3-(2-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine inhibits ATP analog-specific PKCdelta isoform Mus musculus
bisindolylmaleimide I
-
 Mus musculus
additional information not inhibited by 1-tert-butyl-3-(2-naphthalenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Mus musculus
staurosporine
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Mus musculus
-
 ADP + phosphorylated protein
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Mus musculus ADP + phosphorylated protein
-
 ?
Nepsilon-(benzyl)-ATP + histone 3
-
 Mus musculus ADP + phosphorylated histone 3
-
 ?
Nepsilon-(benzyl)-ATP + RFARKGSLRQKNV
-
 Mus musculus Nepsilon-(benzyl)-ADP + RFARKGpSLRQKNV
-
 ?

Synonyms

Synonyms Comment Organism
AS PKCdelta
-
 Mus musculus
ATP analog specific protein kinase Cdelta
-
 Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000154
-
 ATP analog-specific PKCdelta isoform, at pH 7.4 and 27°C Mus musculus 1-(tert-butyl)-3-(1-naphthyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
0.000221
-
 ATP analog-specific PKCdelta isoform, at pH 7.4 and 27°C Mus musculus bisindolylmaleimide I
0.00167
-
 ATP analog-specific PKCdelta isoform, at pH 7.4 and 27°C Mus musculus staurosporine
0.0026
-
 ATP analog-specific PKCdelta isoform, at pH 7.4 and 27°C Mus musculus 1-(tert-butyl)-3-(2-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine