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Literature summary for 2.7.11.13 extracted from

  • Harper, M.T.; Poole, A.W.
    Isoform-specific functions of protein kinase C: the platelet paradigm (2007), Biochem. Soc. Trans., 35, 1005-1008.
    View publication on PubMed
Search for more literature for 2.7.11.13

Activating Compound

Activating Compound Comment Organism Structure
Diacylglycerols activate PKC isozymes Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
Go6976
-
 Mus musculus
rottlerin specific inhibitor of isozyme PKCdelta Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates, required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + vasodilator-stimulated phosphoprotein Mus musculus phosphorylation at Ser157 ADP + phosphorylated vasodilator-stimulated phosphoprotein
-
 ?
additional information Mus musculus PKC signalling has been suggested to play a role in Ca2+ entry, granule secretion, alphaIIbbeta3 activation and outside-in signalling, PKC also is involved in receptor desensitization, extrusion of intracellular Ca2+, secretion and actin-mediated filopodia formation, PKC negatively regulates platelet activation and the diverse processes in which active platelet are involved, detailed overview, PKC increases Ca2+ extrusion from the cytosol and desensitizes some G-protein coupled receptors, isozyme PKCdelta inhibits platelet aggregation by inhibiting VASP phosphorylation at Ser157, reducing filopodial extension, overview, PKCdelta is required for dense granule secretion following stimulation by thrombin, and plays a negative regulatory role in dense granule secretion when platelets are stimulated by convulxin, PKCtheta is also required for outside-in signalling and, as with PKCbeta, platelets deficient in PKCtheta do not fully spread on a fibrinogen-coated surface ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 PKC isoforms can be split into three groups: conventional, novel and atypical, overview
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + vasodilator-stimulated phosphoprotein phosphorylation at Ser157 Mus musculus ADP + phosphorylated vasodilator-stimulated phosphoprotein
-
 ?
additional information PKC signalling has been suggested to play a role in Ca2+ entry, granule secretion, alphaIIbbeta3 activation and outside-in signalling, PKC also is involved in receptor desensitization, extrusion of intracellular Ca2+, secretion and actin-mediated filopodia formation, PKC negatively regulates platelet activation and the diverse processes in which active platelet are involved, detailed overview, PKC increases Ca2+ extrusion from the cytosol and desensitizes some G-protein coupled receptors, isozyme PKCdelta inhibits platelet aggregation by inhibiting VASP phosphorylation at Ser157, reducing filopodial extension, overview, PKCdelta is required for dense granule secretion following stimulation by thrombin, and plays a negative regulatory role in dense granule secretion when platelets are stimulated by convulxin, PKCtheta is also required for outside-in signalling and, as with PKCbeta, platelets deficient in PKCtheta do not fully spread on a fibrinogen-coated surface Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
More PKCs form a family of related serine/threonine kinases that are part of the AGC-type kinase, kinase G/protein kinase C-family kinase, superfamily Mus musculus
PKC
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus